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Drug: Acetylcysteine
Nutrition: Antidoxidants
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Total 707 results found since Jan 2013.
N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury
This study aimed to evaluate whether N-acetylcysteine (NAC) has hepatoprotective effects against ADR-induced hepatotoxicity in rats. In addition, it was aimed to determine how Meteorin-Like (MtrnL), which has pleiotropic effects on immunology, inflammation, and metabolism, is affected by ADR and/or NAC applications in liver tissue. 28 rats were randomly assigned to one of four equal groups in the study: control (no treatment), NAC (150 mg/kg/day of NAC intraperitoneally (i.p), ADR (15 mg/kg only on the first day of the experiment), and ADR + NAC (ADR 15 mg/kg on the first day of the experiment + 150 mg/kg/day NAC i.p). Aft...
Source: Cell Stress and Chaperones - September 5, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Ahmet Tektemur Tuncay Kulo ğlu Source Type: research
Metallothionein Gene Deficiency Facilitates the Differentiation of C2C12 Myoblasts into Slow-Twitch Myotubes
In this study, we investigated the effect of MT1 and MT2 gene knock-out using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (CRISPR-Cas9) system in an in vitro skeletal muscle differentiation model (C2C12 cell line). MT deficiency promoted myogenic differentiation and myotube formation in C2C12 cells. Muscle-specific transcription factors MyoD and myogenin were found to be upregulated at the late stage of myotube differentiation in MTKO cells. Furthermore, the fast-twitch myosin heavy chain (MyHC) protein expression was similar in MTKO and mock-transfected myotubes, but ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yoshito Kadota Ryo Yamanokuchi Nodoka Ohnishi Mami Matsuoka Takashige Kawakami Masao Sato Shinya Suzuki Source Type: research
A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis
In conclusion, gestational Sb exposure disrupted oxidative stress homeostasis, thereby impairing growth and development.PMID:37666440 | DOI:10.1016/j.freeradbiomed.2023.09.002
Source: Free Radical Biology and Medicine - September 4, 2023 Category: Biology Authors: Xiaoke Wang Peiyao Zhou Ziyang Zhang Qiuru Huang Xia Chen Li Ji Xinmeng Cheng Yi Shi Shali Yu Juan Tang Chi Sun Xinyuan Zhao Jun Yu Source Type: research
Metallothionein Gene Deficiency Facilitates the Differentiation of C2C12 Myoblasts into Slow-Twitch Myotubes
In this study, we investigated the effect of MT1 and MT2 gene knock-out using the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (CRISPR-Cas9) system in an in vitro skeletal muscle differentiation model (C2C12 cell line). MT deficiency promoted myogenic differentiation and myotube formation in C2C12 cells. Muscle-specific transcription factors MyoD and myogenin were found to be upregulated at the late stage of myotube differentiation in MTKO cells. Furthermore, the fast-twitch myosin heavy chain (MyHC) protein expression was similar in MTKO and mock-transfected myotubes, but ...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Yoshito Kadota Ryo Yamanokuchi Nodoka Ohnishi Mami Matsuoka Takashige Kawakami Masao Sato Shinya Suzuki Source Type: research
Aflatoxin B1-induced early developmental hepatotoxicity in larvae zebrafish
Chemosphere. 2023 Aug 25:139940. doi: 10.1016/j.chemosphere.2023.139940. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is a ubiquitous mycotoxin that causes oxidative damage in various organs. At present, the research studies on AFB1 are primarily focused on its effects on the terrestrial environment and animals. However, its toxicity mechanism in aquatic environments and aquatic animals has not been largely explored. Thus, in this study, zebrafish was used as a model to study the toxicity mechanism of AFB1 on the liver of developing larvae. The results showed that AFB1 exposure inhibited liver development and promoted...
Source: Chemosphere - August 27, 2023 Category: Chemistry Authors: Chi Feng Hongxia Bai Xu Chang Zhixuan Wu Wu Dong Qianqian Ma Jingfeng Yang Source Type: research
Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells
Int J Mol Sci. 2023 Aug 9;24(16):12590. doi: 10.3390/ijms241612590.ABSTRACTMultiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative a...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anna Staskiewicz Erica Wong Michael Tucker Riya Farhin Jonathan Park Rana Saade Tina Alkhazali Tu Dang Xinyu Wang Source Type: research
Potential Use of Antioxidant Compounds for the Treatment of Inflammatory Bowel Disease
Pharmaceuticals (Basel). 2023 Aug 14;16(8):1150. doi: 10.3390/ph16081150.ABSTRACTSince inflammatory bowel diseases (IBDs) are chronic, the development of new effective therapeutics to combat them does not lose relevance. Oxidative stress is one of the main pathological processes that determines the progression of IBD. In this regard, antioxidant therapy seems to be a promising approach. The role of oxidative stress in the development and progression of IBD is considered in detail in this review. The main cause of oxidative stress in IBD is an inadequate response of leukocytes to dysbiosis and food components in the intesti...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Alexander V Blagov Varvara A Orekhova Vasily N Sukhorukov Alexandra A Melnichenko Alexander N Orekhov Source Type: research
Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells
Int J Mol Sci. 2023 Aug 9;24(16):12590. doi: 10.3390/ijms241612590.ABSTRACTMultiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative a...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anna Staskiewicz Erica Wong Michael Tucker Riya Farhin Jonathan Park Rana Saade Tina Alkhazali Tu Dang Xinyu Wang Source Type: research
Role of ROS-mediated PERK/ATF4 signaling activation in extracorporeal tube formation injury of human umbilical vein endothelial cells induced by cooking oil fume PM < sub > 2.5 < /sub > exposure
This study aimed to investigate the role of ROS-mediated PERK/ATF4 signaling activation in COF-PM2.5-inhibited extracorporeal tube formation in human umbilical vein endothelial cells (HUVECs). HUVECs were treated with 100 μg/mL COF-PM2.5 at different times, with or without 100 nM PERK activity inhibitor GSK2606414 (GSK) or 200 μM antioxidant N-acetylcysteine (NAC) pretreatment. Our results showed that COF-PM2.5 exposure can inhibit extracorporeal tube formation and down-regulate VEGFR2 expression in HUVECs. Furthermore, our data indicated that COF-PM2.5 exposure can activate the PERK/ATF4 signaling in HUVECs. Mechanistic...
Source: Ecotoxicology and Environmental Safety - August 23, 2023 Category: Environmental Health Authors: Shu Sun Chao Zhang Qi Zhang Changlian Li Dan Huang Rui Ding Jiyu Cao Jiahu Hao Source Type: research
