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Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts.
CONCLUSIONS: Our study suggests that a higher bacterial diversity may reduce the risk of allergic rhinitis later in childhood. The environment-dependent heterogeneity in the associations with inhalant atopy - visible here as inconsistent results between two differing cohorts - suggests that specific constituents of the diversity may be relevant.
PMID: 33582132 [PubMed - as supplied by publisher]
Source: Environmental Research - February 11, 2021 Category: Environmental Health Authors: Hyytiäinen H, Kirjavainen PV, Täubel M, Tuoresmäki P, Casas L, Heinrich J, Herberth G, Strandl M, Renz H, Piippo-Savolainen E, Hyvärinen A, Pekkanen J, Karvonen AM Tags: Environ Res Source Type: research
IgE and T Cell Reactivity to a Comprehensive Panel of Cockroach Allergens in Relation to Disease
IgE sensitization to cockroach allergens is associated with development of allergic diseases, such as asthma. To understand the relevance of different cockroach allergens for diagnosis and immunotherapy, a comprehensive analysis of IgE antibody levels and T cell reactivity to an expanded set of cockroach allergens and their relationship to disease was performed in a cohort of USA cockroach sensitized patients. IgE antibody levels to recombinant chitinase and hemocyanin were measured for 23 subjects by custom-made ImmunoCAPs and compared with IgE levels to eight cockroach allergens we previously reported for the same cohort...
Source: Frontiers in Immunology - February 10, 2021 Category: Allergy & Immunology Source Type: research
Purification and initial studies on vitellogenin, an allergen in German cockroach
German cockroach (Blattella germanica) is a source of important urban indoor aeroallergens, associated with allergic rhinitis and asthma. Vitellogenin, a high molecular mass and abundant protein in B. germanica eggs and egg cases (oothecae), was purified and assessed for its allergenicity.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Joshua Somers, Benjamin Rosen, Coby Schal, Taruna Khurana, Samuel Mindaye, Jay Slater Source Type: research
Dysregulation of Circulating Monocytes is Associated with Exposure to Air Pollution and Asthma in Children
Although it is recognized that exposure to ambient air pollution containing particulate matter with a diameter of less than 2.5 micrometers (PM2.5) is responsible for more than a million cases of childhood asthma per year, the underlying mechanisms remain to be precisely addressed. It has not been demonstrated whether increased levels of exposure to PM2.5 is associated with dysregulation of monocytes in healthy and asthmatic children, or if pollution primes monocytes to develop a hyperinflammatory response termed “trained immunity”.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Hesam Movassagh, Mary Prunicki, Eric Smith, Diane Dunham, Xiaoying Zhou, German Aleman Muench, Pejman Soroosh, Kari Nadeau Source Type: research
Airborne pollen analysis during one year in the city of Trelew, Argentina
The city of Trelew is located on the west coast of Argentina Patagonia, with unique geographic characteristics close to the Atlantic Ocean. Since there are no previous studies, a study of air pollen was carried out during 12 months.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Gabriel Fueyo, Laura Barrionuevo, German Ramon Source Type: research
Wind Influence on the Grass Airborne Pollen in Bah ía Blanca, Argentina
The objective of this work was to identify the influence of the wind direction and speed on the airborne grass pollen during the year 2019 in the city of Bah ía Blanca. Its geographical location is by the sea in the southwest of Buenos Aires province.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: German Ramon, Laura Barrionuevo, Graciela Benedetti, Valeria Duval Source Type: research
Ukko Secures $40 Million in Series B Funding Led by Leaps by Bayer to Overcome Food Allergies and Sensitivities
Top industry leaders and venture firms unite behind Ukko's efforts to eliminate the world's most prevalent food allergies and sensitivities, including peanuts and gluten
PALO ALTO, Calif., TEL AVIV, Israel and LEVERKUSEN, Germany, Jan. 27, 2021 -- (Heal... Biopharmaceuticals, Venture Capital Ukko, Bayer, food allergy
Source: HSMN NewsFeed - January 27, 2021 Category: Pharmaceuticals Source Type: news
mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry
“No!” The doctor snapped. “Look at me!”
I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed.
This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Health - January 11, 2021 Category: Consumer Health News Authors: Walter Isaacson Tags: Uncategorized COVID-19 feature Magazine Source Type: news
Atopic Dermatitis in the Pediatric Population: A Cross-sectional, International, Epidemiologic Study.
CONCLUSION: This global survey in 18 countries showed that AD affects a substantial proportion of the pediatric population. Although prevalence and severity varied across age groups and countries, <15% had severe AD.
PMID: 33421555 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 6, 2021 Category: Allergy & Immunology Authors: Silverberg JI, Barbarot S, Gadkari A, Simpson EL, Weidinger S, Mina-Osorio P, Rossi AB, Brignoli L, Saba G, Guillemin I, Fenton MC, Auziere S, Eckert L Tags: Ann Allergy Asthma Immunol Source Type: research
House dust mite immunotherapy in Germany: real-world adherence to a subcutaneous allergoid and a sublingual tablet
ConclusionIn this retrospective real-world cohort analysis in Germany, patients on subcutaneous AIT for HDM respiratory allergy achieved significantly higher adherence rates compared to the HDM-SLIT tablet over a 3-year treatment period. In addition, days on therapy were significantly higher for SCIT than for SLIT. It was shown that in real life significantly more patients receiving SCIT stay on the recommended treatment period of 3 years compared to SLIT subjects. This is important since effectiveness ha s been demonstrated to be linked with therapy duration.
Source: Allergo Journal International - December 17, 2020 Category: Allergy & Immunology Source Type: research
Healthcare provision for insect venom allergy patients during the COVID-19 pandemic
AbstractThe population prevalence of insect venom allergy ranges between 3 –5%, and it can lead to potentially life-threatening allergic reactions. Patients who have experienced a systemic allergic reaction following an insect sting should be referred to an allergy specialist for diagnosis and treatment. Due to the widespread reduction in outpatient and inpatient care c apacities in recent months as a result of the COVID-19 pandemic, the various allergy specialized centers in Germany, Austria, and Switzerland have taken different measures to ensure that patients with insect venom allergy will continue to receive optima...
Source: Allergo Journal International - December 8, 2020 Category: Allergy & Immunology Source Type: research
Diagnostic Criteria for Odontogenic Sinusitis: A Systematic Review.
CONCLUSIONS: Current diagnostic criteria for odontogenic sinusitis are extremely heterogeneous. Establishing shared diagnostic criteria aimed at defining both sinusitis and related odontogenic foci would spur collaboration between investigators and support more comprehensive outcomes evaluations together with a better understanding of treatment options.
PMID: 33236664 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - November 25, 2020 Category: ENT & OMF Authors: Allevi F, Fadda GL, Rosso C, Martino F, Pipolo C, Cavallo G, Felisati G, Saibene AM Tags: Am J Rhinol Allergy Source Type: research
Airlines provide too little information for allergy sufferers!
DiscussionThe information offered by many airlines for passengers with allergies is insufficient. To offer greater guidance, updated information has been formulated in German and English, and its use is recommended.
Source: Allergo Journal International - November 20, 2020 Category: Allergy & Immunology Source Type: research
Predominant patterns of β-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins
Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsi...
Source: Allergy, Asthma and Clinical Immunology - November 17, 2020 Category: Allergy & Immunology Authors: Philipp Schr üfer, Knut Brockow, Johanna Stoevesandt and Axel Trautmann Tags: Research Source Type: research
