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Re-exposure to iodinated contrast media in two patients with prior severe hypersensitivity reaction
CONCLUSION: Rapid desensitization is an effective and safe strategy that may allow other patients with similar allergies to successfully undergo angiography that requires the use of radiocontrast media.PMID:34958304 | DOI:10.5414/CP204086
Source: International Journal of Clinical Pharmacology and Therapeutics - December 27, 2021 Category: Drugs & Pharmacology Authors: Suyan Zhu Honglin Zhou Ruochi Zhao Yu Sun Hanbin Cui Source Type: research

Risk factors and prevention for perioperative anaphylaxis: a nested case-control study
Conclusion In this study, history of drug allergy and history of allergies to food or other substances were significantly associated with perioperative anaphylaxis. Avoiding culprit drugs or taking rational anti-allergy premedication was critical to prevent perioperative anaphylaxis for surgical patients with high-risk factors.
Source: International Journal of Clinical Pharmacy - September 16, 2019 Category: Drugs & Pharmacology Source Type: research

The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC –MS Based Metabolomics
Conclusion In this study, serum and urine metabolites identified by GC–MS and general pharmacodynamic evaluation (morphological observation, histopathology, inflammatory factors, and visceral indices) were used to compare the effects of GJ and LGWWJX decoctions on cold asthma. Significant metabolic abnormalities were observed for 37 metabolites (15 in serum, 22 in urine) in rats with cold asthma. These altered metabolites might be potential biomarkers or therapeutic targets during development of cold asthma. Furthermore, pathway analysis demonstrated that pathways associated with energy metabolism and oxidative str...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Conclusion Via a HPLC system and a BATMAN-TCM platform, for the first time we performed detailed HPLC fingerprint analysis and network pharmacology studies of QP ointment. By in-depth animal and molecular analysis, we identified a number of chronic dermatitis-associated Th1/2 cytokines, itch mediators, and cellular signaling pathways in the skin, DRG and serum for QP to treat the inflammation and chronic itch associated with ACD. Our data clearly suggested, upon stimulation, cytokines and itch-related mediators are released from the skin and neuronal tissues, and QP could effectively work on both the skin and sensory neur...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015.
CONCLUSIONS: Our findings suggest that clinicians should pay attention to psychiatric ADRs and be alert for SARs, especially when three or more AEDs are used together. Moreover, active surveillance might provide another method of pharmacovigilance in China. PMID: 30642405 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - January 17, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Suppression of TGP on myocardial remodeling by regulating the NF-κB pathway
This study aims to investigate the effects of TGP on myocardial remodeling by regulating the nuclear factor kappa B cells (NF-κB) pathway. SD rats were selected and divided into five groups (n = 8), control, sham-operated, Captopril, low dose TGP and high dose TGP respectively. The pressure-overload method was adopted by abdominal aorta ligation to induce the CHF. Furthermore, collagen fibers detected by picrosirius red staining and expression of NF-kB, TGF-β1 by immunohistochemistry and observed under a polarized microscope and assessed by image-pro plus 6.0. Matrix metalloproteinase’s (MMP)-2, -9 mRNA levels by r...
Source: Biomedicine and Pharmacotherapy - October 10, 2018 Category: Drugs & Pharmacology Source Type: research