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Intra-breath oscillometry is a sensitive test for assessing disease control in adults with severe asthma
CONCLUSION: Oscillometry, particularly the intra-breath variation, better reflected asthma control than spirometry measures. Our findings suggest that oscillometry may be a useful technique to aid management of severe asthma with the potential to reflect loss of disease control.PMID:34146698 | DOI:10.1016/j.anai.2021.06.005
Source: Annals of Allergy, Asthma and Immunology - June 19, 2021 Category: Allergy & Immunology Authors: Joseane Chiabai Frederico Orlando Friedrich Morgana Tha ís Carollo Fernandes Faradiba Sarquis Serpa Marcos Ot ávio Brum Antunes Firmino Braga Neto Gergely Makan Zolt án Hantos Peter D Sly Marcus Herbert Jones Source Type: research
The Delta Variant Could Soon Become the Dominant COVID-19 Strain. Here ’s What You Need to Know
The COVID-19 pandemic is increasingly becoming an arms race among the emerging variants of the virus, and at the moment, there’s no question which one is winning: the Delta variant—formally known as B.1.617.2—one of four strains to have emerged originally in India. It was just last month that the World Health Organization labeled Delta a “variant of concern”—joining with the Alpha strain, which emerged in the U.K.; the Beta strain, from South Africa; and the Gamma strain, first seen in Brazil. But Delta is fast becoming the most worrisome of the bunch.
Health officials are sounding the a...
Source: TIME: Science - June 15, 2021 Category: Science Authors: Alejandro de la Garza and Jeffrey Kluger Tags: Uncategorized COVID-19 Source Type: news
What We Learned About Genetic Sequencing During COVID-19 Could Revolutionize Public Health
You don’t want to be a virus in Dr. David Ho’s lab. Pretty much every day since the COVID-19 pandemic began, Ho and his team have done nothing but find ways to stress SARS-CoV-2, the virus that causes the disease. His goal: pressure the virus relentlessly enough that it mutates to survive, so drug developers can understand how the virus might respond to new treatments. As a virologist with decades of experience learning about another obstinate virus, HIV, Ho knows just how to apply that mutation-generating stress, whether by starving the virus, bathing it in antibodies that disrupt its ability to infect cells, ...
Source: TIME: Health - June 11, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 feature Genetics Magazine Source Type: news
Purification and characterisation of the dimeric group 12 allergen from Blomia tropicalis heterologously expressed by Escherichia coli Top10F ´
Mol Biol Rep. 2021 Apr 29. doi: 10.1007/s11033-021-06361-6. Online ahead of print.ABSTRACTSuccessful research in the wide-ranging field of allergy is usually achieved by definition not only of physicochemical and immunological properties of natural, but also recombinant allergens. Blomia tropicalis mite is a well-known source for various groups of hypersensitivity-causing proteins. The goal of the present work was to produce, purify and characterise by in silico, biochemical and immunological methods the recombinant group-12 allergen of B. tropicalis. The recombinant Blo t 12 aggregation capacity as well as the affinity to...
Source: Molecular Biology Reports - April 29, 2021 Category: Molecular Biology Authors: Eduardo Santos da Silva Luis Gustavo Carvalho Pacheco Ant ônio Márcio Santana Fernandes Claudia Asam Elis ânia Fontes Silveira Carina da Silva Pinheiro Neuza Maria Alcantara-Neves Source Type: research
IJERPH, Vol. 18, Pages 4501: Prevalence of Skin Reactions and Self-Reported Allergies in 5 Countries with Their Social Impact Measured through Quality of Life Impairment
Conclusions: Quantifying the prevalence and the association of allergies with skin reactions and discomfort sensations is critical to evaluating the impact on quality of life. Since skin barrier alteration is hypothesized as a risk factor and a route of sensitization for allergy development, the daily use of topical treatments, such as moisturizers, could help prevent allergic skin reactions, discomfort and impaired quality of life in individuals with an altered skin barrier.
Source: International Journal of Environmental Research and Public Health - April 23, 2021 Category: Environmental Health Authors: Salah Taieb Demessant Haftek Tags: Article Source Type: research
Johnson & Johnson Single-Shot COVID-19 Vaccine Phase 3 Data Published in New England Journal of Medicine
NEW BRUNSWICK, N.J., April 21, 2021 – Johnson & Johnson (the Company) today announced publication in the New England Journal of Medicine of primary data from the Phase 3 ENSEMBLE clinical trial for its single-dose COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen). The publication of the primary analysis follows the topline efficacy and safety data announced in January, showing the trial met all primary and key secondary endpoints, and found that the Johnson & Johnson single-dose COVID-19 vaccine prevented hospitalization and death across all study participants ...
Source: Johnson and Johnson - April 21, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news
Asthmatic Symptoms in Children and Adolescents: the Role of Maternal Experiences of Racial Discrimination
ConclusionMaternal discrimination was associated with asthma symptoms and with non-atopic phenotype among their children. Enjoying wider social support network appears to buffer the effect on asthmatic symptoms. Intervention on childhood asthma needs to incorporate strategies that target the family.
Source: Journal of Racial and Ethnic Health Disparities - April 5, 2021 Category: International Medicine & Public Health Source Type: research
Johnson & Johnson Expands Phase 2a Clinical Trial of COVID-19 Vaccine Candidate to Include Adolescents
New Brunswick, NJ (April 2, 2021) – Johnson & Johnson (the Company) has begun vaccinating adolescent participants in the ongoing Phase 2a clinical trial for its COVID-19 vaccine candidate, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson. “The COVID-19 pandemic has had a profound impact on adolescents, not just with the complications of the disease, but with their education, mental health, and wellbeing,” said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer at Johnson & Johnson. “It is vital that we develop vaccines for everyone, everywher...
Source: Johnson and Johnson - April 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news
A genome-wide association study of severe asthma exacerbations in Latino children and adolescents
Severe asthma exacerbations are a major cause of school absences and healthcare costs in children, particularly those in high-risk racial/ethnic groups.
To identify susceptibility genes for severe asthma exacerbations in Latino children and adolescents, we conducted a meta-analysis of genome-wide association studies (GWAS) in 4010 Latino youth with asthma in four independent cohorts, including 1693 Puerto Ricans, 1019 Costa Ricans, 640 Mexicans, 256 Brazilians and 402 members of other Latino subgroups. We then conducted methylation quantitative trait locus, expression quantitative trait locus and expression quantitative tr...
Source: European Respiratory Journal - April 1, 2021 Category: Respiratory Medicine Authors: Yan, Q., Forno, E., Herrera-Luis, E., Pino-Yanes, M., Qi, C., Rios, R., Han, Y.-Y., Kim, S., Oh, S., Acosta-Perez, E., Zhang, R., Hu, D., Eng, C., Huntsman, S., Avila, L., Boutaoui, N., Cloutier, M. M., Soto-Quiros, M. E., Xu, C.-J., Weiss, S. T., Lasky-S Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Severe cutaneous adverse drug reactions: diagnostic approach and genetic study in a Brazilian case series
Conclusions. A systematized approach allowed the phenotypic characterization of SCAR. The HLA-A*31:01, B*57:01 and B*58:01 alleles were identified, reinforcing the causality in SCAR by CBZ, ABC and ALLO in the Brazilian population.PMID:33728835 | DOI:10.23822/EurAnnACI.1764-1489.193
Source: European Annals of Allergy and Clinical Immunology - March 17, 2021 Category: Allergy & Immunology Authors: M I Perell ó A de Maria Castro A C Nogueira Arraes S Caracciolo Costa D Lacerda Pedrazzi G Andrade Coelho Dias L Morette Hanhoerster L C Porto F Chigres Kuschnir E Costa Source Type: research
Allergic contact dermatitis by ophthalmological medications in Brazil: experience of a dermatology department
Eur Ann Allergy Clin Immunol. 2021 Mar 16. doi: 10.23822/EurAnnACI.1764-1489.190. Online ahead of print.ABSTRACTTopical treatments in ophthalmologic therapy are significant for the development of allergic contact dermatitis (ACD) in the periorbital region. Preservatives, antibiotics, glucocorticoids, and beta-blocker eye drops are defined as drugs with the highest sensitizing potential. The unavailability of patch test batteries containing substances of ophthalmological use makes it difficult for this diagnosis. In the present report, we describe six patients who developed ACD induced by different agents presenting in eye ...
Source: European Annals of Allergy and Clinical Immunology - March 17, 2021 Category: Allergy & Immunology Authors: Y K Chan E S Novalo Goto R Fachini Jardim Criado P R Criado Source Type: research
Severe cutaneous adverse drug reactions: diagnostic approach and genetic study in a Brazilian case series
Conclusions. A systematized approach allowed the phenotypic characterization of SCAR. The HLA-A*31:01, B*57:01 and B*58:01 alleles were identified, reinforcing the causality in SCAR by CBZ, ABC and ALLO in the Brazilian population.PMID:33728835 | DOI:10.23822/EurAnnACI.1764-1489.193
Source: European Annals of Allergy and Clinical Immunology - March 17, 2021 Category: Allergy & Immunology Authors: M I Perell ó A de Maria Castro A C Nogueira Arraes S Caracciolo Costa D Lacerda Pedrazzi G Andrade Coelho Dias L Morette Hanhoerster L C Porto F Chigres Kuschnir E Costa Source Type: research
