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Condition: Pregnancy
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Periostin acts as a bridge between gestational diabetes mellitus (GDM) and chronic inflammation to modulate insulin resistance by modulating PPAR α/NF-κB/TNF-α signaling pathway
CONCLUSION: POSTN levels were significantly higher in pregnant women with GDM and were associated with chronic inflammation and PPARα expression. POSTN may act as a bridge between GDM and chronic inflammation to modulate insulin resistance by modulating PPARα/NF-κB/TNF-α signaling pathway.PMID:37106515 | DOI:10.2174/1871530323666230427104724
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 28, 2023 Category: Endocrinology Authors: Qun Ji Xinying Li Yan Wang Haiwei Liu Kaining Chen Huibiao Quan Huachuan Zhang Jianmin Ran Source Type: research
HIF-1 α is positively associated with endometrial receptivity by regulating PKM2
CONCLUSIONS: HIF-1α plays a crucial role in the building of ER through regulating glycolysis.PMID:37533344 | DOI:10.1111/jog.15752
Source: Cell Research - August 3, 2023 Category: Cytology Authors: Lixia Liang Yang Yang Lin Yang Xiuping Zhang Suming Xu Yanling Liu Xueqing Wu Lan Chao Source Type: research
Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia
CONCLUSIONS: Placental PEG10 is reduced in patients with early-onset preeclampsia. In vitro studies suggest that hypoxia and inflammation may contribute to PEG10 downregulation. Reduced PEG10 alters canonical TGF-[Formula: see text] signalling, and thus may be involved in trophoblast dysfunction associated with this pathway.PMID:37464405 | PMC:PMC10355026 | DOI:10.1186/s12958-023-01116-3
Source: Reproductive Biology - July 18, 2023 Category: Reproduction Medicine Authors: Lydia Baird Ping Cannon Manju Kandel Tuong-Vi Nguyen Anna Nguyen Georgia Wong C íara Murphy Fiona C Brownfoot Elif Kadife Natalie J Hannan Stephen Tong Lucy A Bartho Tu'uhevaha J Kaitu'u-Lino Source Type: research
Periostin acts as a bridge between gestational diabetes mellitus (GDM) and chronic inflammation to modulate insulin resistance by modulating PPAR α/NF-κB/TNF-α signaling pathway
CONCLUSION: POSTN levels were significantly higher in pregnant women with GDM and were associated with chronic inflammation and PPARα expression. POSTN may act as a bridge between GDM and chronic inflammation to modulate insulin resistance by modulating PPARα/NF-κB/TNF-α signaling pathway.PMID:37106515 | DOI:10.2174/1871530323666230427104724
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 28, 2023 Category: Drugs & Pharmacology Authors: Qun Ji Xinying Li Yan Wang Haiwei Liu Kaining Chen Huibiao Quan Huachuan Zhang Jianmin Ran Source Type: research
Abstract 275: Tissue Transglutaminase Stabilizes Placental AT1 Receptor and Contributes to Pathophysiology in Preeclampsia Poster Session I
Preeclampsia (PE) is a serious hypertensive disease of pregnancy associated with the presence of the major angiotensin receptor AT1-agnostic autoantibodies (AT1-AAs) that cause the defining PE features when introduced into pregnant mice. To understand AT1-AA-mediated receptor activation in PE, we explored the role of tissue transglutaminases (TG2), the most ubiquitous member of a group of enzymes modifying proteins by catalyzing the formation of -(-glutamyl)-lysine isopeptide bonds. TG2, a versatile protein that can also function as a G protein, is enriched in the syncytiotrophoblasts of placenta, the key organ in PE patho...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Liu, C., Wang, W., Parchim, N., Irani, R., Ning, C., Sun, K., Zhao, S., Zhao, C., Song, A., Zhang, Y., Blackwell, S., Sibai, B., Jin, J., Kellems, R., Xia, Y. Tags: Poster Session I Source Type: research
Abstract 280: Sflt-1 is Regulated via Both Transcriptional and Post-transcriptional Modification in Preeclampsia Poster Session I
Preeclampsia (PE) is a life-threatening hypertensive renal disorder of pregnancy. Soluble fms-like tyrosine kinase 1 (sFlt-1), an anti-angiogenic factor, is elevated and contributes to PE. However, molecular basis underlying its up-regulation in PE remains unclear. Here we report that hypoxia inducible factor-1α (HIF-1α), an important transcriptional factor, and U2AF65, a key molecule involved in alternative splicing, are significantly increased in the placentasof PE patients compared to the controls. Using two animal models of PE including angiotensin receptor type 1 receptor agonistic autoantibody (AT1-AA) an...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Wang, W., Parchim, N., Iriyama, T., Luo, R., Zhao, C., Zhang, Y., Blackwell, S., Sabai, B., Tao, L., Kellems, R., Xia, Y. Tags: Poster Session I Source Type: research
Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.
CONCLUSIONS: HDACs inhibition could up-regulate placental MRP2 expression in vitro, and HDAC1 was probably to be involved in this process.
PMID: 28524836 [PubMed - in process]
Source: Chinese Medical Journal - May 21, 2017 Category: General Medicine Authors: Duan HY, Ma D, Zhou KY, Wang T, Zhang Y, Li YF, Wu JL, Hua YM, Wang C Tags: Chin Med J (Engl) Source Type: research
Effect of IL-15-Mediating IFN- γ on HTR-8/SVneo Cells and a Preeclampsia Mouse Model Induced by Lipopolysaccharides
Conclusion: IL-15 inhibition reduced cell apoptosis and increased the invasive and migratory abilities of LPS-induced HTR-8/SVneo cells, thereby alleviating the PE-like phenotype and improving pregnancy outcome.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - June 9, 2021 Category: OBGYN Source Type: research
Talin1 is highly expressed in the fallopian tube and chorionic villi to promote trophoblast invasion in tubal pregnancy
CONCLUSION: The expression of Talin1 in the fallopian tube and chorionic villi is significantly increased in women with tubal pregnancy, suggesting the association of Talin1-regulated trophoblast cell invasion with the occurrence of tubal pregnancy.PMID:35527499 | PMC:PMC9085590 | DOI:10.12122/j.issn.1673-4254.2022.04.19
Source: Journal of Southern Medical University - May 9, 2022 Category: Universities & Medical Training Authors: P Qiu X Lin G Deng Source Type: research
