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Use of antihistamines before or during pregnancy and risk of early-onset pre-eclampsia in allergic women: a population-based cohort study
Conclusions Antihistamine use before or during placentation was associated with reduced risk of developing early-onset pre-eclampsia in allergic women compared with women using antihistamines after placentation.
Source: BMJ Open - October 7, 2022 Category: General Medicine Authors: Sande, A. K., Torkildsen, E. A., Sande, R. K., Dalen, I., Danielsson, K. C., Morken, N.-H. Tags: Open access Obstetrics and gynaecology Source Type: research

Association of Prenatal Antibiotics and Mode of Birth With Otolaryngology Surgery in Offspring: A National Data Linkage Study
Conclusions: Antibiotic exposure in pregnancy and cesarean section may adversely affect early immune development and increase the risk of recurrent upper airway infections and allergy/atopy that may require otolaryngology surgery. Mechanistic studies are warranted to explore genetic and/or molecular pathways that explain these findings. This may identify potential therapeutic targets to reduce the burden of otolaryngology surgery.
Source: The Pediatric Infectious Disease Journal - April 16, 2022 Category: Infectious Diseases Tags: Original Studies Source Type: research

155. Antihistamine use in pregnancy and risk of early-onset preeclampsia
Introduction:/aims: Pregestational maternal allergy is an isolated risk factor for early-onset preeclampsia. The aim of this study was to assess the association between maternal use of antihistamines and early-onset preeclampsia, Methods: A population-based cohort study with data from the Medical Birth Registry of Norway and the Norwegian Prescription Database 2004-2016. We divided the prescription of antihistamines into pregestational (last six months before conception), first half of pregnancy (from conception to week 20) and second half of pregnancy (from week 20 to 36).
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 1, 2022 Category: OBGYN Authors: A. Sande, E. Torkildsen, R. Sande, K. Danielsson, N. Morken Source Type: research

Johnson & Johnson Single-Shot COVID-19 Vaccine Phase 3 Data Published in New England Journal of Medicine
NEW BRUNSWICK, N.J., April 21, 2021 – Johnson & Johnson (the Company) today announced publication in the New England Journal of Medicine of primary data from the Phase 3 ENSEMBLE clinical trial for its single-dose COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen). The publication of the primary analysis follows the topline efficacy and safety data announced in January, showing the trial met all primary and key secondary endpoints, and found that the Johnson & Johnson single-dose COVID-19 vaccine prevented hospitalization and death across all study participants ...
Source: Johnson and Johnson - April 21, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial
Publication date: Available online 19 February 2020Source: The LancetAuthor(s): Håvard Ove Skjerven, Eva Maria Rehbinder, Riyas Vettukattil, Marissa LeBlanc, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Linn Landrø, Benjamin J Marsland, Knut Rudi, Kathrine Dønvold Sjøborg, Cilla Söderhäll, Anne Cathrine Staff, Kai-Håkon Carlsen, Anna Asarnoj, Karen Eline Stensby Bains, Oda C Lødrup Carlsen, Kim M Advocaat Endre, Peder Annæus Granlund, Johanne Uthus HermansenSummaryBackgroundSkin emollients applied during early infancy could prevent atopic dermatitis, and early complementary food introduction might reduce food all...
Source: The Lancet - February 21, 2020 Category: General Medicine Source Type: research

Maternal levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort.
We examined the association of PFASs measured in pregnancy with childhood asthma, allergies and common infectious diseases in a prospective pregnancy cohort followed to age 7 years. MATERIAL AND METHODS: Six PFASs (out of 19 measured) with at least 80% of measurements above the limit of quantification (LOQ) in maternal plasma during pregnancy in two subcohorts of the Norwegian Mother and Child Cohort Study (MoBa) were analyzed in relation to health outcomes: perfluorooctane sulfonic acid (PFOS), acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDA), and ...
Source: Environment International - January 23, 2019 Category: Environmental Health Authors: Impinen A, Longnecker MP, Nygaard UC, London SJ, Ferguson KK, Haug LS, Granum B Tags: Environ Int Source Type: research

Maternal age at delivery, lung function and asthma in offspring: a population-based survey
There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex. 10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25–55 years. In logistic and linear multilevel mixed models we adjusted for participants’ charac...
Source: European Respiratory Journal - June 7, 2018 Category: Respiratory Medicine Authors: Gomez Real, F., Burgess, J. A., Villani, S., Dratva, J., Heinrich, J., Janson, C., Jarvis, D., Koplin, J., Leynaert, B., Lodge, C., Laerum, B. N., Matheson, M. C., Norbäck, D., Omenaas, E. R., Skulstad, S. M., Sunyer, J., Dharmage, S. C., Svanes, Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma Source Type: research

Long-Term Exposure to Transportation Noise in Relation to Development of Obesity —a Cohort Study
Conclusion: Our results link transportation noise exposure to development of obesity and suggest that combined exposure from different sources may be particularly harmful. https://doi.org/10.1289/EHP1910 Received: 17 March 2017 Revised: 5 October 2017 Accepted: 9 October 2017 Published: 20 November 2017 Address correspondence to A. Pyko, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Telephone: 46(0) 852487561. Email: Andrei.pyko@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP1910). The authors declare they have no actual or potential competing fina...
Source: EHP Research - November 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

US Lags Far Behind in Banning Dental Health Hazard
Example of mercury use in the healthcare sector. From left to right: Mercury Sphygmomanometer, Dental Amalgam and a Fever Thermometer. Credit: UNDPBy Thalif DeenUNITED NATIONS, Jul 31 2017 (IPS)The United States is lagging far behind its Western allies – and perhaps most of the key developing countries – in refusing to act decisively to end a longstanding health and environmental hazard: the use of mercury in dentistry. The 28-member European Union (EU), with an estimated population of over 510 million people, recently announced its decision to ban amalgam use in children under age 15, pregnant women, and breastfeeding...
Source: IPS Inter Press Service - Health - July 31, 2017 Category: International Medicine & Public Health Authors: Thalif Deen Tags: Environment Featured Global Global Governance Headlines Health Inequity IPS UN: Inside the Glasshouse Population Regional Categories Sustainability TerraViva United Nations Source Type: news

Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study
Conclusions: Our results suggest significant inverse associations between maternal urinary TCS and cord blood FT3 as well as maternal blood FT4 concentrations at third trimester. https://doi.org/10.1289/EHP500 Received: 11 May 2016 Revised: 05 October 2016 Accepted: 07 November 2016 Published: 27 June 2017 Address correspondence to F. Ouyang, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Rd., Shanghai 200092 China. Telephone: 86-21-2507-8867. Email: ouyangfx@yahoo.com The authors declare they have no actual or poten...
Source: EHP Research - June 27, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research