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Condition: Atrial Fibrillation
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Total 200 results found since Jan 2013.

Thrombotic and Bleeding Outcomes Following Perioperative Interruption of Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Non-Valvular Atrial Fibrillation - a Comparative Analysis
Conclusions: The perioperative interruption of warfarin was associated with a higher 30-day rate of major bleeding as compared with DOAC interruption. Re-initiation of warfarin should be done judiciously following high bleeding risk procedures, and close INR monitoring may be warranted.DisclosuresShaw: Portola Pharmaceuticals: Research Funding. Douketis: Janssen: Consultancy; Pfizer: Other: Advisory Board; Boehringer-Ingelheim: Consultancy, Other: Advisory Board, Research Funding; Portola: Other: Advisory Board; The Medicines Company: Other: Advisory Board; Daiichi-Sankyo: Other: Advisory Board; Biotie: Other: Advisory Boa...
Source: Blood - November 21, 2018 Category: Hematology Authors: Shaw, J. R., Zhang, T., Le Gal, G., Douketis, J., Carrier, M. Tags: 332. Antithrombotic Therapy: Poster I Source Type: research

Peri-Device Leak after Left Atrial Appendage Closure: Incidence, Risk Factors and Clinical Impact
ConclusionsPDL rate detected by CCTA after LAAC is high, especially in cases with low device compression ratio (<10%), but decreased over time. The incidence of MACE was quantitatively greater with PDL, but the difference was not statistically significant. Larger studies are needed to determine the clinical importance of PDL.
Source: Canadian Journal of Cardiology - December 21, 2018 Category: Cardiology Source Type: research

Prothrombotic state in atrial fibrillation patients with 1 additional risk factor of the CHA2DS2-VASc score (beyond sex)
ConclusionsA prothrombotic state (increased thrombin generation, denser fibrin clots, impaired fibrinolysis, and endothelial injury) characterizes AF patients with one additional clinical stroke risk factor (beyond sex), with age 65-74 years being particularly associated with a prothrombotic indices.
Source: Canadian Journal of Cardiology - January 30, 2019 Category: Cardiology Source Type: research

Peridevice Leak After Left Atrial Appendage Closure: Incidence, Risk Factors, and Clinical Impact
ConclusionsThe PDL rate detected by CCTA after LAAC was high, especially in cases with a low device compression ratio (< 10%), but decreased over time. The incidence of MACE was quantitatively greater with PDL, but the difference was not statistically significant. Larger studies are needed to determine the clinical importance of PDL.RésuméIntroductionPeu d’études ont fait état des taux et des répercussions cliniques des fuites périprothétiques (FPP) après la fermeture de l’appendice auriculaire gauche (AAG) par voie percutanée.MéthodesNous avons inscrit de manière prospective tous les patients consécuti...
Source: Canadian Journal of Cardiology - March 30, 2019 Category: Cardiology Source Type: research

Periprocedural Anticoagulation for Cardioversion of Acute Onset Atrial Fibrillation and Flutter: Evidence Base for Current Guidelines
Publication date: Available online 12 June 2019Source: Canadian Journal of CardiologyAuthor(s): Jason G. Andrade, L. Brent MitchellABSTRACTThe practice of electrical or pharmacological cardioversion (CV) to restore sinus rhythm in patents with symptomatic atrial fibrillation (AF) or atrial flutter (AFL) has been a part of clinical practice for over 100 years. For almost as long as CV has been performed, it has been recognised that the act of restoring sinus rhythm is associated with an increased risk of stroke and systemic embolism, and that oral anticoagulation (OAC) therapy can be used to prevent peri-CV thromboembolism....
Source: Canadian Journal of Cardiology - June 13, 2019 Category: Cardiology Source Type: research

Anticoagulation in Patients with Advanced Chronic Kidney Disease: Walking the Fine Line between Benefit and Harm
Publication date: Available online 11 July 2019Source: Canadian Journal of CardiologyAuthor(s): Januvi Jegatheswaran, Gregory L. Hundemer, David Massicotte-Azarniouch, Manish M. SoodAbstractChronic kidney disease affects over 3 million Canadians and is highly associated with cardiovascular diseases that require anticoagulation, such as atrial fibrillation and venous thromboembolism. Patients with chronic kidney disease are at a problematic crossroads; they are at high risk of both thrombotic conditions requiring anticoagulation and bleeding complications due to anticoagulation. The limited high-quality clinical evidence to...
Source: Canadian Journal of Cardiology - July 12, 2019 Category: Cardiology Source Type: research

Perioperative Atrial Fibrillation in Non-Cardiac Surgeries for Malignancies and One-Year Recurrence
ConclusionsAF recurs in approximately thirty percent of POAF patients with malignancy in the subsequent year; most recurrences are asymptomatic.
Source: Canadian Journal of Cardiology - July 12, 2019 Category: Cardiology Source Type: research

Bleeding tolerance among patients with atrial fibrillation on oral anticoagulation
ConclusionsThe key determinants of the Bleeding Ratio among anticoagulated AF patients are age, prior thromboembolic and bleeding episodes. The study could support identification of AF patients who need additional effort to increase their acceptance of a life-long OAC therapy.
Source: Canadian Journal of Cardiology - September 18, 2019 Category: Cardiology Source Type: research

Perioperative Atrial Fibrillation in Noncardiac Surgeries for Malignancies and One-Year Recurrence
ConclusionsAF recurs in approximately 30% of patients with POAF with malignancy in the subsequent year; most recurrences are asymptomatic.RésuméContexteIl arrive fréquemment qu’un patient subissant une intervention chirurgicale non cardiaque présente une fibrillation auriculaire périopératoire (FAPO). On ne sait toutefois pas si d’autres épisodes de fibrillation auriculaire (FA) surviennent par la suite.MéthodologieLes auteurs ont mené une étude d’observation prospective unicentrique auprès de patients ayant subi une intervention chirurgicale non cardiaque visant à retirer une tumeur. Les patients ont fai...
Source: Canadian Journal of Cardiology - November 2, 2019 Category: Cardiology Source Type: research

Costs of surgical ablation of atrial fibrillation in Ontario, Canada from 2006 to 2017
ConclusionOntario taxpayers spend significant financial resources on surgical ablation of AF, a procedure lacking high ‐quality evidence demonstrating benefit in reducing mortality or stroke. Further large prospective studies examining clinically important outcomes are needed to justify its routine use in patient care and to guide allocation of healthcare funds.
Source: Journal of Cardiac Surgery - September 27, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Justin Y. Chow, Graham McClure, Emilie P. Belley ‐Côté, William F. McIntyre, Rohit K. Singal, Richard P. Whitlock Tags: ORIGINAL ARTICLE Source Type: research

Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results from the CABANA Trial.
Conclusions: Clinically relevant treatment-related strategy differences in the primary and secondary clinical outcomes of CABANA were not seen between men and women, and there were no sex differences in adverse events. The CABANA trial results support catheter ablation as an effective treatment strategy for both women and men. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT00911508. PMID: 33499668 [PubMed - as supplied by publisher]
Source: Circulation - January 27, 2021 Category: Cardiology Authors: Russo AM, Zeitler EP, Giczewska A, Silverstein AP, Al-Khalidi HR, Cha YM, Monahan KH, Bahnson TD, Mark DB, Packer DL, Poole JE, CABANA Investigators Tags: Circulation Source Type: research

Trends in Anticoagulant Use at Nursing Home Admission and Variation by Frailty and Chronic Kidney Disease Among Older Adults with Atrial Fibrillation
ConclusionsWhile the proportion of residents with AF receiving oral anticoagulants at admission increased following the approval of DOACs, over 40% remained untreated. Among those treated, use of a DOAC increased, while warfarin use declined. The impact of these recent treatment patterns on the balance between benefit and harm among residents warrant further investigation.
Source: Drugs and Aging - April 21, 2021 Category: Geriatrics Source Type: research

EP News: Quality Improvement and Outcomes: Defining and Measuring Atrial Fibrillation Quality Indicators in Canada
In 2016, the Working Group published an initial report identifying and defining priority QIs in 3 distinct categories: access to care, treatment, and outcomes (Can J Cardiol 2016;32:1566, PMID 27297003). An iterative process resulted in the selection of 3 priority QIs: (i) proportion of AF patients at high risk of stroke receiving an oral anticoagulant, (ii) annual rate of stroke, (iii) annual rate of major hemorrhage. A feasibility assessment followed, which determined that none of the QIs as defined could be adequately measured with existing data sources.
Source: Heart Rhythm - April 26, 2021 Category: Cardiology Authors: Roopinder K. Sandhu, Stephen B. Wilton, Anne Marie Smith, Paul Dorian Source Type: research

Dose Specific Effectiveness and Safety of DOACs in Patients with Non-valvular Atrial Fibrillation: a Canadian Retrospective Cohort Study
Direct oral anticoagulants (DOACs) have been proven to be effective and safe for prevention of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF). However, suboptimal adherence, variable dosing and use in patient populations that otherwise would have been excluded from clinical trials may impact the efficacy and safety profile of DOACs in a routine care setting. We compared stroke, bleeding, and mortality rates on and off therapy for standard and low-dose DOACs (apixaban, rivaroxaban, dabigatran) versus warfarin in a Canadian cohort.
Source: Thrombosis Research - May 10, 2021 Category: Hematology Authors: Elham Rahme, Richard Godin, Hacene Nedjar, Kaberi Dasgupta, Vicky Tagalakis Source Type: research

Cardiovascular disease and the risk of dementia: a survival analysis using administrative data from Manitoba
CONCLUSION: A diagnosis of CVD is associated with an increased risk of a future diagnosis of dementia. Promoting good cardiovascular health may serve as an effective measure for preventing dementia.PMID:35025100 | DOI:10.17269/s41997-021-00589-2
Source: Canadian Journal of Public Health - January 13, 2022 Category: International Medicine & Public Health Authors: Luc Clair Hope Anderson Christopher Anderson Okechukwu Ekuma Heather J Prior Source Type: research