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Specialty: Cardiology
Condition: Aortic Stenosis

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Total 670 results found since Jan 2013.

Economic Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Low Surgical Risk: Results from the PARTNER 3 Trial
CONCLUSIONS: For patients with severe aortic stenosis and low surgical risk similar to those enrolled in the PARTNER 3 trial, transfemoral TAVR with the SAPIEN 3 valve is cost saving compared with SAVR at 2 years and is projected to be economically attractive in the long run as long as there are no substantial differences in late death between the 2 strategies. Long-term follow-up will be critical to ultimately determine the preferred treatment strategy for low-risk patients from both a clinical and economic perspective.PMID:37154049 | DOI:10.1161/CIRCULATIONAHA.122.062481
Source: Circulation - May 8, 2023 Category: Cardiology Authors: Benjamin Z Galper Khaja M Chinnakondepalli Kaijun Wang Elizabeth A Magnuson Michael Lu Vinod H Thourani Susheel Kodali Raj Makkar Howard C Herrmann Samir Kapadia Mathew Williams John Webb Craig R Smith Michael J Mack Martin B Leon David J Cohen PARTNER In Source Type: research

Left-ventricular reverse remodeling after transcatheter aortic valve implantation in patients with low-flow low-gradient aortic stenosis
CONCLUSIONS: The majority of patients with LFLG AS show LVRR after TAVI, which is associated with favorable outcome. An SVI of < 25ml/m2, LVEF < 30% and Zva < 5mmHg/ml/m2 represent predictors of LVRR.PMID:37119968 | DOI:10.1016/j.hjc.2023.04.009
Source: Hellenic Journal of Cardiology - April 29, 2023 Category: Cardiology Authors: Nihal G Wilde Victor Mauri Kerstin Piayda Baravan Al-Kassou Jasmin Shamekhi Oliver Maier Vedat Tiyerili Atsushi Sugiura Marcel Weber Sebastian Zimmer Tobias Zeus Malte Kelm Matti Adam Stephan Baldus Georg Nickenig Verena Veulemans Alexander Sedaghat Source Type: research

Proof of concept study on coronary microvascular function in low flow low gradient aortic stenosis
Conclusions CMD is more severe in patients with LFLGAS compared with NFHGAS and is associated with low-flow state, left atrial dysfunction and reduced cardiac performance.
Source: Heart - April 25, 2023 Category: Cardiology Authors: Scarsini, R., Pighi, M., Mainardi, A., Portolan, L., Springhetti, P., Mammone, C., Della Mora, F., Fanti, D., Tavella, D., Gottin, L., Bergamini, C., Benfari, G., Pesarini, G., Ribichini, F. L. Tags: Valvular heart disease Source Type: research

Lipoprotein (a), Inflammation, and Atherosclerosis
J Clin Med. 2023 Mar 27;12(7):2529. doi: 10.3390/jcm12072529.ABSTRACTGrowing evidence has shown that high levels of lipoprotein (a) (Lp(a)) and chronic inflammation may be responsible for the residual risk of cardiovascular events in patients managed with an optimal evidence-based approach. Clinical studies have demonstrated a correlation between higher Lp(a) levels and several atherosclerotic diseases including ischemic heart disease, stroke, and degenerative calcific aortic stenosis. The threshold value of Lp(a) serum concentrations associated with a significantly increased cardiovascular risk is >125 nmol/L (50 mg/dL...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Stefania Angela Di Fusco Aldo Pietro Maggioni Pietro Scicchitano Marco Zuin Emilia D'Elia Furio Colivicchi Source Type: research

Suitability of TAVI in low-risk patients
Nature Reviews Cardiology, Published online: 21 March 2023; doi:10.1038/s41569-023-00862-6In the Evolut Low Risk study, transcatheter aortic valve implantation in low-risk patients with severe aortic stenosis compared favourably with surgical aortic valve replacement in terms of all-cause mortality or disabling stroke at 3 years.
Source: Nature Reviews Cardiology - March 21, 2023 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Clonal Hematopoiesis and the Heart: a Toxic Relationship
Curr Oncol Rep. 2023 Mar 15. doi: 10.1007/s11912-023-01398-1. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Clonal hematopoiesis (CH) refers to the expansion of hematopoietic stem cell clones and their cellular progeny due to somatic mutations, mosaic chromosomal alterations (mCAs), or copy number variants which naturally accumulate with age. CH has been linked to increased risk of blood cancers, but CH has also been linked to adverse cardiovascular outcomes.RECENT FINDINGS: A combination of clinical outcome studies and mouse models have offered strong evidence that CH mutations either correlate with or cause atheroscle...
Source: Atherosclerosis - March 15, 2023 Category: Cardiology Authors: Jeffrey L Jensen Saumya Easaw Travis Anderson Yash Varma Jiandong Zhang Brian C Jensen Catherine C Coombs Source Type: research

Meta-Analysis of Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement
Transcatheter aortic valve replacement (TAVR) has emerged as an effective therapy for patients with severe aortic stenosis, irrespective of surgical risks.1 Stroke due to cerebral embolization of debris is a devastating periprocedural complication of TAVR and is associated with poor outcomes. The risk of stroke could be decreased by capturing the debris using cerebral embolic protection (CEP) devices.2 An analysis of the TVT (Transcatheter Valve Therapy) Registry showed that CEPs were used in 28% of centers and 13% of all procedures.
Source: The American Journal of Cardiology - February 27, 2023 Category: Cardiology Authors: Ahmad Al-Abdouh, Mohammed Mhanna, Ahmad Jabri, Taha Ahmed, Ahmed M. Altibi, Fares Ghanem, Laith Alhuneafat, Ayman Albadawi, Mahmoud Barbarawi, Nakeya Dewaswala, Huzefa Bhopalwala, Amartya Kundu, Islam Y. Elgendy Source Type: research

Rescue aortic valvuloplasty for severe aortic stenosis is simple and effective in severely hemodynamically compromised patients presenting to centers without on-site heart surgery or TAVI facilities
AbstractManagement of high-risk patients with severe aortic stenosis (AS) is a challenging issue. The prognosis of patients with AS presenting  with therapy-refractory pulmonary edema (RPE) or cardiogenic shock (CS) remains poor. The purpose of this study was to assess the 30-day mortality of rescue percutaneous balloon aortic valvuloplasty (PBAV) in AS patients presenting with RPE or CS in a community-based hospital without on- site heart surgery. From January 2016 to February 2019, we identified consecutively admitted patients with CS or RPE related to severe AS who underwent emergent PBAV. The primary end...
Source: Heart and Vessels - February 13, 2023 Category: Cardiology Source Type: research

Thrombocytopenia Following Perceval Sutureless Aortic Valve Replacement in Asian Patients
CONCLUSIONS: Thrombocytopenia was common after Perceval sutureless AVR, although its impact was not significant. Although Perceval sutureless AVR was found to be a safe and effective option, preoperative assessment of potential bleeding should be performed and the Perceval valve should not be used for patients with a high bleeding risk.PMID:36709983 | DOI:10.1253/circj.CJ-22-0587
Source: Circulation Journal - January 29, 2023 Category: Cardiology Authors: Taisuke Nakayama Yoshitsugu Nakamura Fumiaki Shikata Masaki Ushijima Yuto Yasumoto Daiki Yoshiyama Miho Kuroda Shintaro Sawa Ryo Tsuruta Akira Furutachi Takuya Narita Yujiro Ito Source Type: research