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Specialty: Cardiology
Condition: Thrombosis

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Total 3531 results found since Jan 2013.

Paroxysmal Atrial Fibrillation in Cryptogenic Stroke: an Overlooked Explanation?
Abstract Approximately one third of ischemic strokes are labeled cryptogenic because the etiology is unknown despite a thorough evaluation. Paroxysmal atrial fibrillation carries the same risk of ischemic stroke as persistent atrial fibrillation and has increasingly gained attention as a potential source of cryptogenic stroke. Recent trials utilizing long-term cardiac monitoring devices have demonstrated high rates of previously undetected paroxysmal atrial fibrillation in patients with cryptogenic stroke. Newly detected atrial fibrillation has subsequently changed treatment and increased the use of oral anticoag...
Source: Current Atherosclerosis Reports - October 20, 2015 Category: Cardiology Source Type: research

Patient-Centered Decision Support in Acute Ischemic Stroke: Qualitative Study of Patients' and Providers' Perspectives Original Articles
Conclusions— This study suggests that a positively framed risk–benefit tool with graphical presentations of general and patient-specific risk estimates could support patients and providers in considering r-tPA for acute ischemic stroke. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01864928.
Source: Circulation: Cardiovascular Quality and Outcomes - October 29, 2015 Category: Cardiology Authors: Decker, C., Chhatriwalla, E., Gialde, E., Garavalia, B., Summers, D., Quinlan, M. E., Cheng, E., Rymer, M., Saver, J. L., Chen, E., Kent, D. M., Spertus, J. A. Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care Original Articles Source Type: research

The role of echocardiography in patients after ischemic stroke
Publication date: Available online 10 March 2016 Source:Cor et Vasa Author(s): Martin Hutyra, Luděk Pavlů, Daniel Šaňák, Jan Přeček, Martin Köcher, Zbyněk Tüdös, Tomáš Skála, Ondřej Moravec, David Vindiš, Miloš Táborský Therapy of acute phase of ischemic central vascular accident is focused on immediate actions to suppress the severity of damage with the earliest possible initiation of reperfusion strategy together with initiation and maintenance of adequate therapy to prevent further cerebral reinfarctions. The key factor for adequate and effective secondary prevention is elucidation of the ...
Source: Cor et Vasa - March 12, 2016 Category: Cardiology Source Type: research

Cardioembolic Stroke - Postmyocardial Infarction Stroke
Ischemic stroke following acute myocardial infarction (AMI) is a rare but serious complication due to left ventricular thrombus formation and atrial fibrillation. Early revascularization of the culprit coronary lesion is essential. Treatment trends may affect the risk. Conversely, the greater use of antiplatelet agents to reduce the risk of ischemic stroke could increase the risk of hemorrhagic stroke. The risk of stroke after AMI has decreased significantly with more use of percutaneous coronary intervention and antithrombotic therapies in the acute setting, and statins, antihypertensive medications, and dual antiplatelet...
Source: Cardiology Clinics - March 12, 2016 Category: Cardiology Authors: Marius Hornung, Jennifer Franke, Sameer Gafoor, Horst Sievert Source Type: research

Cardioembolic Stroke and Postmyocardial Infarction Stroke
Ischemic stroke following acute myocardial infarction (AMI) is a rare but serious complication due to left ventricular thrombus formation and atrial fibrillation. Early revascularization of the culprit coronary lesion is essential. Treatment trends may affect the risk. Conversely, the greater use of antiplatelet agents to reduce the risk of ischemic stroke could increase the risk of hemorrhagic stroke. The risk of stroke after AMI has decreased significantly with more use of percutaneous coronary intervention and antithrombotic therapies in the acute setting, and statins, antihypertensive medications, and dual antiplatelet...
Source: Cardiology Clinics - March 11, 2016 Category: Cardiology Authors: Marius Hornung, Jennifer Franke, Sameer Gafoor, Horst Sievert Source Type: research

Evidence-Based Carotid Interventions for Stroke Prevention: State-of-the-art Review.
Authors: Morris DR, Ayabe K, Inoue T, Sakai N, Bulbulia R, Halliday A, Goto S Abstract Carotid artery stenosis is responsible for between 10-20% of all ischaemic strokes. Interventions, such as carotid endarterectomy and carotid stenting, effectively reduce the risk of stroke in selected individuals. This review describes the history of carotid interventions, and summarises reliable evidence on the safety and efficacy of these interventions gained from large randomised clinical trials.Early trials comparing carotid endarterectomy to medical therapy alone in symptomatic patients, and asymptomatic patients, demonstra...
Source: Journal of Atherosclerosis and Thrombosis - March 8, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Transcatheter aortic valve thrombosis: the relation between hypo-attenuated leaflet thickening, abnormal valve haemodynamics, and stroke
Conclusion</div>On MDCT, 12.5% of patients showed HALT or reduced leaflet motion, whereas only one of these patients had abnormal valve haemodynamics on echocardiography. Neither HALT nor increased transvalvular gradient were associated with stroke/TIA.</span>
Source: European Heart Journal - March 27, 2017 Category: Cardiology Source Type: research

New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator
ConclusionThese results show that MMP10, either alone or in combination with tPA, might represent a new strategy for thrombolysis in ischemic stroke, providing higher protection against cerebrovascular damage.
Source: Cardiovascular Research - April 3, 2017 Category: Cardiology Source Type: research

Established and potential echocardiographic markers of embolism and their therapeutic implications in patients with ischemic stroke.
Abstract Cardiogenic strokes comprised 11% of all strokes and 25% of ischemic strokes. An accurate identification of the cause of stroke is necessary in order to prepare an adequate preventive strategy. In this review the confirmed and potential causes of embolic strokes are presented, which can be detected in echocardiography in the context of present treatment guidelines and gaps in evidence. There remains a need for further studies assessing the meaning of potential cardiac sources of embolism and establishment of rules for optimal medical prevention (antiplatelet therapy [APT] vs. oral anticoagulation [OAC]) a...
Source: Cardiology Journal - May 2, 2018 Category: Cardiology Authors: Gąsiorek PE, Banach M, Maciejewski M, Głąbiński A, Paduszyńska A, Rysz J, Bielecka-Dąbrowa A Tags: Cardiol J Source Type: research

T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by P-Selectin Binding.
CONCLUSIONS: The study identifies lymphopenia as a previously unrecognized risk factor for secondary hemorrhagic transformation in mice after severe ischemic stroke. T cells prevent hemorrhagic transformation by their capacity to bind platelets through P-selectin. The results highlight the role of T cells in bridging immunity and hemostasis in ischemic stroke. PMID: 29903733 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 14, 2018 Category: Cardiology Authors: Salas-Perdomo A, Miró-Mur F, Urra X, Justicia C, Gallizioli M, Zhao Y, Brait VH, Laredo C, Tudela R, Hidalgo A, Chamorro Á, Planas AM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.
CONCLUSIONS: The present study demonstrates for the first time a graded relation between TMAO levels and the risk of subsequent cardiovascular events in patients with recent prior ischemic stroke. Our data support the notion that TMAO-related increase of proinflammatory monocytes may add to elevated cardiovascular risk of patients with increased TMAO levels. PMID: 29976769 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 5, 2018 Category: Cardiology Authors: Haghikia A, Li XS, Liman TG, Bledau N, Schmidt D, Zimmermann F, Kränkel N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Fraccarollo D, Heimesaat MM, Bauersachs J, Wang Z, Zhu W, Bavendiek U, Hazen SL, Endres M, Landmesser U Tags: Arterioscler Thromb Vasc Biol Source Type: research

Cerebral Arterial Stiffness as A New Marker of Early Stage Atherosclerosis of The Cerebral Large Artery in Acute Stroke.
CONCLUSIONS: Cerebral arterial stiffness has the potential to be a new marker of early stage atherosclerosis of the cerebral large artery. This finding may help us prevent the occurrence of stroke and decrease the burden of society from stroke patients. PMID: 30662019 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - January 23, 2019 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Cardiac papillary fibroelastoma and stroke during pregnancy: Case report.
We report the case of a woman with severe headache associated with visual disturbances, without hypertension or proteinuria at 32 weeks of pregnancy. MRI revealed multiple recent cerebral vascular accidents. An echocardiogram detected a papillary fibroelastoma of 5mm. Maternal fetal experts determined it safe to continue the pregnancy. Childbirth at 39 weeks was normal uneventful for the newborn and mother. In the postpartum, despite the theoretical operative indication to resect the small residual papillary fibroelastoma, the patient was followed expectantly because of the stable neuro-cardiologic state. A fibroelastoma c...
Source: Annales de Cardiologie et d'Angeiologie - January 24, 2019 Category: Cardiology Authors: Binhas M, Zakine C, Khelil N, Mekacher L, Wafo E, Lebonhomme JJ, Iung B Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Left Atrial Appendage Occlusion as Adjunctive Therapy to Anticoagulation for Stroke Recurrence.
CONCLUSIONS: LAAO as an adjunctive therapy to OAC seems to be feasible and safe in patients with previous cardioembolic events despite optimal OAC. In our series, this strategy was associated with a low rate of cerebrovascular events after LAAO. PMID: 31088992 [PubMed - as supplied by publisher]
Source: The Journal of Invasive Cardiology - May 16, 2019 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

mtDNA Copy Number Contributes to All-Cause Mortality of Lacunar Infarct in a Chinese Prospective Stroke Population
AbstractThe study aimed to investigate the relationship between mtDNA copy number and the risk of all-cause mortality in stroke. One thousand four hundred eighty-four stroke patients were documented including 273 deaths (127 thrombosis, 52 lacunar, 94 hemorrhage). Patients in the third quartile had the lowest mortality rates in overall stroke and the three subtypes. The lowest quartile of mtDNA copy number (Q1<  85.85) indicated an increased risk of all-cause mortality in stroke patients (adjusted HR, 1.52; 95% CI, 1.08–2.14;p = 0.017). In the subtype analysis, the risk of all-cause mortality appeared only in la...
Source: Journal of Cardiovascular Translational Research - December 10, 2019 Category: Cardiology Source Type: research