T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by P-Selectin Binding.

CONCLUSIONS: The study identifies lymphopenia as a previously unrecognized risk factor for secondary hemorrhagic transformation in mice after severe ischemic stroke. T cells prevent hemorrhagic transformation by their capacity to bind platelets through P-selectin. The results highlight the role of T cells in bridging immunity and hemostasis in ischemic stroke. PMID: 29903733 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29903733?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 14, 2018 Category: Cardiology Authors: Salas-Perdomo A, Miró-Mur F, Urra X, Justicia C, Gallizioli M, Zhao Y, Brait VH, Laredo C, Tudela R, Hidalgo A, Chamorro Á, Planas AM Tags: Arterioscler Thromb Vasc Biol Source Type: research