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Condition: Stroke
Drug: Chantix
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Total 34 results found since Jan 2013.
Delayed Varenicline Administration Reduces Inflammation and Improves Forelimb Use Following Experimental Stroke
Pharmacological activation of the cholinergic anti-inflammatory pathway (CAP), specifically by activating α7 nicotinic acetylcholine receptors, has been shown to confer short-term improvements in outcome. Most studies have investigated administration within 24 hours of stroke, and few have investigated drugs approved for use in human patients. We investigated whether delayed administration of varenicli ne, a high-affinity agonist at α7 nicotinic receptors and an established therapy for nicotine addiction, decreased brain inflammation and improved functional performance in a mouse model of experimental stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2017 Category: Neurology Authors: Siyi Chen, Laura Bennet, Ailsa L. McGregor Source Type: research
Cardiovascular and mortality risks in older Medicare patients treated with varenicline or bupropion for smoking cessation: an observational cohort study
ConclusionCardiovascular and mortality risks were not increased in older patients treated with varenicline compared with bupropion for smoking cessation. A potential increase in the risk of stroke with varenicline could not be excluded. Treatment persistence with either drug was low. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
Source: Pharmacoepidemiology and Drug Safety - July 5, 2014 Category: Drugs & Pharmacology Authors: David J. Graham, Kunthel By, Stephen McKean, Andrew Mosholder, Cynthia Kornegay, Judith A. Racoosin, Jessica Young, Mark Levenson, Thomas E. MaCurdy, Chris Worrall, Jeffrey A. Kelman Tags: Original Report Source Type: research
Annual budgetary impact of varenicline as part of a smoking cessation strategy in Greece
Conclusions: Varenicline reimbursement may represent a balanced strategy from a budget impact perspective in Greece even taking into account hospital resource utilization only.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Katsaounou, P., Bilitou, A., Tsekouras, V. Tags: 6.3 Tobacco, Smoking Control and Health Education Source Type: research
'No serious heart risks' linked to smoking cessation therapies
The American Heart Association claims that three different types of smoking cessation therapies do not pose serious heart risks, quashing concerns that certain products may increase the risks of heart attack, stroke or heart-related death.Researchers looked at the results of 63 clinical trials involving 30, 508 people who were quitting smoking using either nicotine replacement gums and patches, the nicotine addiction treatment varenicline (Chantix), or taking the antidepressant bupropion (Wellbutrin), which can reduce cravings and other unwanted withdrawal effects.
Source: Health News from Medical News Today - December 13, 2013 Category: Consumer Health News Tags: Smoking / Quit Smoking Source Type: news
Research Roundup
DHA study finds no effect on PTSD symptoms after injury
Extended‐release guanfacine effective for youths with autism
Retrospective study of varenicline finds no evidence of adverse risk
Adjunctive quetiapine may improve outcomes in PMDD treatment
Tricyclic antidepressants associated with recurrence of stroke
Cognition not altered in postmenopausal women on hormones
Source: The Brown University Psychopharmacology Update - November 20, 2015 Category: Psychiatry Tags: Research Roundup Source Type: research
Study: Nicotine Patch Works as Well as Chantix to Help Quit Smoking
This study confirms that FDA-approved medications are effective in helping smokers quit,” said Lee Westmaas, PhD, American Cancer Society director of tobacco control research. “Smokers should seriously consider using medications if they are finding it difficult to quit without any help. The most effective approach to quitting is using medications in combination with counseling such as from a quit-line.”RESOURCES: How to Quit Smoking Quit-smoking medicationsResearch shows that using a medication to help you quit smoking can double your chances of being successful.The US Food and Drug Administration (...
Source: American Cancer Society :: News and Features - February 2, 2016 Category: Cancer & Oncology Tags: Smoking/Tobacco Source Type: news
How to Quit Smoking
By Stacy Simon Tobacco use remains the single largest preventable cause of disease and premature death in the United States. Since the release of the Surgeon General’s Report on Smoking and Health 50 years ago, there have been 20 million deaths due to tobacco. Almost half the deaths from 12 different types of cancer combined – including lung, voice box, throat, esophagus, and bladder cancers – are attributable to cigarette smoking alone. In addition to cancer, smoking greatly increases the risk of debilitating long-term lung diseases like emphysema and chronic bronchitis. It also raises the risk for heart...
Source: American Cancer Society :: News and Features - November 16, 2016 Category: Cancer & Oncology Tags: Smoking/Tobacco Source Type: news
Cost ‐effectiveness of alternative smoking cessation scenarios in Spain: results from the EQUIPTMOD
ConclusionsAccording to the EQUIPTMOD modelling tool it would be cost‐effective for the Spanish authorities to expand the reach of existing GP brief interventions for smoking cessation, provide pro‐active telephone support, and reimburse smoking cessation medication to smokers trying to stop. Such policies would more than pay for themselves in the long run.
Source: Addiction - March 13, 2018 Category: Addiction Authors: Marta Trapero ‐Bertran, Celia Muñoz, Kathryn Coyle, Doug Coyle, Adam Lester‐George, Reiner Leidl, Bertalan Németh, Kei‐Long Cheung, Subhash Pokhrel, Ángel Lopez‐Nicolás Tags: Research Report Source Type: research
Estimates of costs for modelling return on investment from smoking cessation interventions
ConclusionsCosts of treating smoking‐attributable diseases as well as the costs of implementing smoking cessation interventions vary substantially across Hungary, Netherlands, Germany, Spain and England. Estimates for the costs of these diseases and interventions can contribute to return on investment estimates in support of national or regional policy decisions.
Source: Addiction - March 13, 2018 Category: Addiction Authors: Marta Trapero ‐Bertran, Reiner Leidl, Celia Muñoz, Puttarin Kulchaitanaroaj, Kathryn Coyle, Maximilian Präger, Judit Józwiak‐Hagymásy, Kei Long Cheung, Mickael Hiligsmann, Subhash Pokhrel, Tags: Research Report Source Type: research
Efficacy of smoking cessation with varenicline plus counselling for e-cigarettes users (VAREVAPE): A protocol for a randomized controlled trial.
Abstract
Tobacco smoking is a global pandemic that poses substantial health burdens and costs. With nearly six million deaths annually, smoking is the single most important cause of avoidable premature mortality in the world, mainly from lung cancer, coronary heart disease, chronic obstructive pulmonary disease and stroke. Smoking is a very difficult addiction to break, even for those with a strong desire to quit. Electronic cigarettes are an attractive long-term alternative source of nicotine to conventional cigarettes because of their many similarities with smoking. Electronic cigarette users report buying them ...
Source: Clinical Lung Cancer - August 8, 2019 Category: Cancer & Oncology Authors: Caponnetto P, Maglia M, Polosa R Tags: Contemp Clin Trials Commun Source Type: research
Varenicline improves cognitive impairment in a mouse model of mPFC ischemia: The possible roles of inflammation, apoptosis, and synaptic factors
This study aimed to examine the effects of varenicline as α7 and α4β2 nicotine acetylcholine receptors (nAChRs) agonist, on cognitive impairment, inflammation, apoptosis, and synaptic dysfunction in mPFC ischemia. Mice were divided to three groups of control, sham, or photothrombotic mPFC ischemia model. The control and sham groups received 2 ml/kg of normal saline for a 14-day period. As well, the animals in the ischemia groups received normal saline (2 ml/kg) or varenicline at 0.1, 1, and 3 mg/kg doses for a 14-day period. Anxiety-like behaviors were then assessed by open field (OFT) and elevated plus-maze (EPM) tests...
Source: Brain Research Bulletin - January 23, 2022 Category: Neurology Authors: Fatemehsadat Seyedaghamiri Leila Hosseini Sareh Kazmi Javad Mahmoudi Dariush Shanehbandi Abbas Ebrahimi-Kalan Reza Rahbarghazi Saeed Sadigh-Eteghad Mehdi Farhoudi Source Type: research
Safety and efficacy of early varenicline prescription in hospitalized patients with acute myocardial infarction: East Asian population
CONCLUSION: This study may represent the first report on the safety and efficacy of early initiation of varenicline treatment in East Asian population hospitalized due to AMI who recently underwent percutaneous coronary intervention.PMID:37002175 | DOI:10.1016/j.jfma.2023.03.016
Source: J Formos Med Assoc - March 31, 2023 Category: General Medicine Authors: Chien-Hsien Lo Li-Ching Li Kai-Wei Chang Chin-Feng Tsai Chun-Hung Su Tse-Hsien Lo Chi-Hua Yen Kuei-Chuan Chan Source Type: research
Top 20 Research Studies of 2022 for Primary Care Physicians
This article summarizes the top 20 research studies of 2022 identified as POEMs (patient-oriented evidence that matters), excluding COVID-19. Statins for primary prevention of cardiovascular disease produce only a small absolute reduction in a person's likelihood of dying (0.6%), having a myocardial infarction (0.7%), or having a stroke (0.3%) over three to six years. Supplemental vitamin D does not reduce the risk of a fragility fracture, even in people with low baseline vitamin D levels or a previous fracture. Selective serotonin reuptake inhibitors are preferred medical therapy for panic disorder, and patients who disco...
Source: American Family Physician - April 13, 2023 Category: Primary Care Authors: Roland Grad Mark H Ebell Source Type: research
