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Specialty: Neurology
Condition: Patent Foramen Ovale

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Total 305 results found since Jan 2013.

Is there a correlation between embolic strokes of undetermined source (ESUS) and patent foramen ovale (PFO)? - A contrasted Transcranial Doppler Ultrasound (cTCD) study. (P6.287)
Conclusions:Massive shunt (the so-called "curtain pattern") during Valsalva maneuver at cTCD was predictive of ESUS in patients with stroke and PFO. The presence of RLS at rest was not statiscally relevant, probably because of the small sample size.Disclosure: Dr. Scavasine has nothing to disclose. Dr. Chamma has nothing to disclose. Dr. Bruch has nothing to disclose. Dr. Braga has nothing to disclose. Dr. Bazan has nothing to disclose. Dr. Massaro has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Lange has nothing to disclose. Dr. Zetola has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Scavasine, V., Chamma, J., Bruch, T., Braga, G., Bazan, R., Massaro, A., Germiniani, F., Lange, M., Zetola, V. Tags: Prevention of Cerebrovascular Disease Source Type: research

From cryptogenic to ESUS: Toward precision medicine?
Rev Neurol (Paris). 2022 May 18:S0035-3787(22)00592-6. doi: 10.1016/j.neurol.2022.01.016. Online ahead of print.ABSTRACTCryptogenic infarctions are infarctions without a defined cause, despite a complete work-up. They differ from infarctions of undetermined causes, which may involve overlapping causes or an incomplete investigation. It is also different from uncommon heritable and non-heritable causes. The term embolic stroke of undetermined source (ESUS) proposed in 2014 is defined as a non-lacunar brain infarct without proximal arterial stenosis or cardioembolic sources. The major advantage of this definition compared to...
Source: Revue Neurologique - May 21, 2022 Category: Neurology Authors: S Timsit Source Type: research

The value of transesophageal echocardiography for embolic strokes of undetermined source
Conclusions: Abnormal TEE findings may decisively affect the selection of appropriate therapeutic strategy in approximately 1 of 7 patients with ESUS.
Source: Neurology - September 4, 2016 Category: Neurology Authors: Katsanos, A. H., Bhole, R., Frogoudaki, A., Giannopoulos, S., Goyal, N., Vrettou, A.-R., Ikonomidis, I., Paraskevaidis, I., Pappas, K., Parissis, J., Kyritsis, A. P., Alexandrov, A. W., Triantafyllou, N., Malkoff, M. D., Voumvourakis, K., Alexandrov, A. V Tags: Cardiac, Embolism ARTICLE Source Type: research

Patent foramen ovale.
Abstract Patent foramen ovale (PFO) is the most common anatomical cause of an interatrial shunt. It is usually asymptomatic but may cause paradoxical embolism, manifesting as stroke, myocardial infarction or visceral/peripheral ischaemia. PFO is a risk factor for stroke and may be associated with migraine with aura. New evidence suggests PFO closure reduces the risk of recurrent ischaemic stroke in a highly selected population of stroke survivors: those aged 60 years or younger with a cryptogenic stroke syndrome, a large right-to-left shunt, an atrial septal aneurysm and no evidence of atrial fibrillation. They be...
Source: Practical Neurology - April 15, 2020 Category: Neurology Authors: Alakbarzade V, Keteepe-Arachi T, Karsan N, Ray R, Pereira AC Tags: Pract Neurol Source Type: research

Clinical Utility of the Transthoracic Echocardiogram for Isolated Lacunar Infarcts: A Single-Center Experience
Conclusions: Transthoracic echocardiogram appears to have minimal therapeutic value in most patients with lacunar strokes. In stroke patients with no acute symptoms of cardiac disease and a normal electrocardiogram, it may be reasonable to forgo the transthoracic echocardiogram if the brain magnetic resonance imaging shows an isolated lacunar infarct.
Source: The Neurologist - May 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Migraine with aura and silent brain infarcts lack of mediation of patent foramen ovale
ConclusionFindings suggest that silent brain infarcts in young patients with cryptogenic stroke is associated with MA. We found no evidence for a mediating effect of PFO on this association.
Source: European Journal of Neurology - July 22, 2013 Category: Neurology Authors: L. Calviere, P. Tall, P. Massabuau, F. Bonneville, V. Larrue Tags: Original Article Source Type: research

Lambl's Excrescences: Association with Cerebrovascular Disease and Pathogenesis
Conclusions: In this study, LEx are similarly prevalent in healthy controls and SLE patients, are not associated with CVD, and are not associated with pathogenic risk factors. Therefore, the study findings suggest that LEx may not be cardioembolic substrates, may not represent pathologic valve structures, and may not require therapy.Cerebrovasc Dis 2015;40:18-27
Source: Cerebrovascular Diseases - June 1, 2015 Category: Neurology Source Type: research

The value of transesophageal echocardiography in the investigation and management of cryptogenic cerebral ischemia: a single-center experience
Abstract The diagnostic utility of transesophageal echocardiography (TEE) has often been challenged in patients with cryptogenic stroke (CS). We estimated the prevalence of different findings on TEE examination of CS patients, their impact on secondary stroke prevention and the presence of potential age or gender disparities. We reviewed all TEE examinations that were performed in a single echocardiography laboratory during a 7-year-old period to identify CS patients that underwent investigation with TEE. Of the 518 total TEE examinations, we identified 88 CS patients. TEE revealed abnormal findings in 69.3 % of ...
Source: Neurological Sciences - December 24, 2015 Category: Neurology Source Type: research

Thrombosis at the Site of Pulmonary Venous Anastomosis Following Lung Transplantation Presenting with Multiple, Bilateral, Supra- and Infra-Tentorial Ischemic Strokes in the Setting of a Known Patent Foramen Ovale (P4.355)
CONCLUSIONS: PFO-related stroke risk over time remains a controversial matter and so does its prevention by closure, as there is no current evidence-based data to justify this procedure except on anecdotal basis. LT patients may represent a subset population who could benefit from pre-operative PFO screening and closure, especially if they have a history of prior strokes.Disclosure: Dr. Yeung has nothing to disclose. Dr. Bakhos has nothing to disclose. Dr. Biller has received personal compensation in an editorial capacity for the Journal of Stroke and Cerebrovascular Diseases, Frontier in Neurology and Up-To-Date.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yeung, S., Bakhos, M., Biller, J. Tags: Cerebrovascular Case Reports Source Type: research

Challenging Cases in Cerebrovascular Disease
We present four cases of stroke of uncommon cause and remind clinicians to be open minded to the many possible causes of stroke, in particular because early recognition and treatment is often critical. Case 1 discusses a patient with inflammatory cerebral amyloid angiopathy. The presentation, ability to recur, and current treatment considerations are reviewed. Case 2 discusses microangiopathic thrombotic angiopathy. Diagnosis and treatment are considered. An association with interferon therapy and the evolving terminology of this and related conditions are discussed. Case 3 discusses intracranial hemorrhage secondary to ac...
Source: Seminars in Neurology - January 9, 2023 Category: Neurology Authors: Kelly, Michael A. Singh, Jasmine Balabanov, Alexandra Wadina, Adam Dasovic, Braden Tags: Review Article Source Type: research

In Context News in brief
Findings from two randomised trials assessing closure of the patent foramen ovale (PFO) versus medical treatment for prevention of recurrent cryptogenic stroke have been inconclusive. In the RESPECT trial in 980 patients (mean age 45·9 years), nine patients in the closure group and 16 in the medical treatment group had recurrent stroke (hazard ratio [HR] 0·49, 95% CI 0·22–1·11). Between groups, rates of serious adverse events did not differ significantly (N Engl J Med 2013; 368: 1092–100). In the multicentre PC trial in 414 patients, the primary endpoint—a composite of death, non-fatal stroke, transient ischaemic...
Source: Lancet Neurology - April 18, 2013 Category: Neurology Authors: The Lancet Neurology Tags: In Context Source Type: research

Migraine and the Risk of Carotid Artery Dissection
Stroke incidence is increasing among patients aged 40 to 60 years —faster than in older age cohorts. Preliminary evidence suggests that ischemic stroke—not hemorrhage or subarachnoid hemorrhage—accounts for the increase. Many speculate that increasing incidences of classic vascular risk factors among young patients contribute to the increased incidence of st roke. Certainly, we are all aware of the obesity epidemic and continued prevalence of smoking, leading to premature atherosclerosis. Furthermore, equally relevant causes of stroke in the young include migraine, drug abuse, cervical arterial dissections, patent fo...
Source: JAMA Neurology - March 6, 2017 Category: Neurology Source Type: research

Recurrent Patent Foramen Ovale-Related Cerebral Infarcts Alternately Causing Bilateral Hand Paresis
Isolated hand paresis is a rare presentation of stroke, which mostly results from a lesion in the cortical hand motor area, a knob-like area within the precentral gyrus. I report the case of a patient who experienced recurrent ischemic stroke alternately involving bilateral hand knob areas, causing isolated hand paresis. There was no abnormal finding on brain and neck magnetic resonance angiography, transthoracic echocardiography, and 48-h Holter monitoring, and there were no abnormal immunologic and coagulation laboratory findings. The only embolic source was found to be a patent foramen ovale, which was proven on transes...
Source: Case Reports in Neurology - August 31, 2017 Category: Neurology Source Type: research