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Specialty: Cardiology
Condition: Patent Foramen Ovale

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Total 614 results found since Jan 2013.

Randomized trials of closure of persistant foramen ovale (PFO) vs medical therapy for patients with cryptogenic stroke – effect of lost-to-follow-up and withdrawal of consent
Foramen ovale is a remnant of the fetal circulation that can be found in all newly born infants and that remain open in about a quarter of adults and the presence of a persistent, or patent, foramen ovale, PFO is associated with cryptogenic stroke [1]. In several observational case-series, cohort studies and registries, device closure of PFO is associated with a significantly lower risk of recurrent stroke or transitory ischemia attacks, TIAs. In the three until today published randomized trials this has not been corroborated however [2–4].
Source: International Journal of Cardiology - January 14, 2016 Category: Cardiology Authors: Mikael Dellborg, Peter Eriksson Source Type: research

Randomized trials of closure of persistent foramen ovale (PFO) vs medical therapy for patients with cryptogenic stroke — Effect of lost-to-follow-up and withdrawal of consent
Foramen ovale is a remnant of the fetal circulation that can be found in all newly born infants and that remain open in about a quarter of adults and the presence of a persistent, or patent, foramen ovale, PFO is associated with cryptogenic stroke [1]. In several observational case-series, cohort studies and registries, device closure of PFO is associated with a significantly lower risk of recurrent stroke or transitory ischemia attacks, TIAs. In the three until today published randomized trials this has not been corroborated however [2–4].
Source: International Journal of Cardiology - January 14, 2016 Category: Cardiology Authors: Mikael Dellborg, Peter Eriksson Tags: Correspondence Source Type: research

Impaired endothelial function in patients with cryptogenic stroke and patent foramen ovale is not affected by closure
DiscussionEndothelial function did not change after closure of PFO. Although patients were lacking cardiovascular risk factors, a high proportion had impaired endothelial function. Whether ED can have predictive value, identifying PFO at higher risk for recurrent stroke warrants further investigations.
Source: Journal of Interventional Cardiology - April 25, 2017 Category: Cardiology Authors: Maria Lantz, Konstantinos Kostulas, Magnus Settergren, Christina Sj östrand Tags: ORIGINAL INVESTIGATION Source Type: research

Potential uselessness and futility of left atrial appendage occlusion and patent foramen ovale closure in cardioembolic stroke
International guidelines indicate that interventional closure of left atrial appendage and patent foramen ovale may be considered in selected patients for stroke prevention. These procedures appear, however, from the published literature, at high risk of uselessness and futility in the single case, if not even capable to induce harm and adverse events. In fact, all reported systematic reviews and meta-analyses have not shown in a convincing manner the superiority of these procedures in stroke prevention, taking into account the occurrence of possible complications also, as compared with alternative medical treatment. On th...
Source: Journal of Cardiovascular Medicine - April 28, 2017 Category: Cardiology Tags: Review Source Type: research

PFO Closure for Cryptogenic Stroke: A Review and Clinical Treatment Algorithm
We describe the historical context of PFO closure and review the observational and randomized control trial evidence in this field, culminating in the recent Food and Drug Administration approval of the first dedicated closure device for PFO. Guidelines and consensus statements are discussed, and a novel treatment algorithm is proposed. Future directions in PFO closure will include new devices, further data from completed and upcoming clinical trials, and potential expansion into other disease states associated with PFO.
Source: Cardiology in Review - June 6, 2017 Category: Cardiology Tags: Review Articles Source Type: research

Patent foramen ovale and cryptogenic stroke
The presence of a patent foramen ovale (PFO) has been found to be associated with an increased risk of cryptogenic stroke in many case-control studies. This paper reviews the current understanding of the pathophysiology and diagnosis of PFO, and therapeutic options of patients with PFO and cryptogenic stroke.
Source: Trends in Cardiovascular Medicine - July 4, 2017 Category: Cardiology Authors: Koki Nakanishi, Minoru Yoshiyama, Shunichi Homma Source Type: research

Patent Foramen Ovale Closure Versus Medical Therapy for Cryptogenic Stroke: Meta-Analysis of Randomised Trials
Patent foramen ovale (PFO) is a common anatomic variant associated with cryptogenic stroke. Percutaneous PFO closure in these patients to prevent recurrent neurological events has been controversial for decades, and mixed results have been reported from past and recent observational and randomised studies. This meta-analysis of randomised trials aims to compare the efficacy and safety of PFO closure with medical therapy for cryptogenic stroke patients.
Source: Heart, Lung and Circulation - March 12, 2018 Category: Cardiology Authors: Tom Kai Ming Wang, Michael Tzu Min Wang, Peter Ruygrok Tags: Original Article Source Type: research

Ischaemic Stroke and the Echocardiographic “Bubble Study”: Are We Screening the Right Patients?
Patent foramen ovale (PFO) is a potential mechanism for paradoxical embolism in cryptogenic ischaemic stroke or transient ischaemic attack (TIA). PFO is typically demonstrated with agitated saline ( “bubble study”, BS) during echocardiography.We hypothesised that the BS is frequently requested in patients that have a readily identifiable cause of stroke, that any PFO detected is likely incidental, and its detection often does not alter management.
Source: Heart, Lung and Circulation - August 1, 2018 Category: Cardiology Authors: Paul Maggiore, Jamie Bellinge, David Chieng, David White, Nick S.R. Lan, Biyanka Jaltotage, Umar Ali, Madeleine Gordon, Kevin Chung, Paul Stobie, Justin Ng, Graeme J. Hankey, Brendan McQuillan Tags: Original Article Source Type: research

Updated Meta-analysis on the Closure of Patent Foramen Ovale in Reduction of Stroke Rates: the DEFENSE-PFO Trial Does not Change the Scenario
Objective: We aimed to analyze whether patent foramen ovale (PFO) closure reduces the risk of stroke, assessing also some safety outcomes after the publication of a new trial.Introduction: The clinical benefit of closing a PFO has been an open question, so it is necessary to review the current state of published medical data in regards to this subject.Methods: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles were used to search for randomized controlled trials (RCTs) that reported any of the following outcomes: stroke, death, ...
Source: Brazilian Journal of Cardiovascular Surgery - November 22, 2018 Category: Cardiology Source Type: research

The Dangerous Patent Foramen Ovale: Device Closure for Stroke Patients with High-Risk Patent Foramen Ovale
We recently read the informative article by Nakayama et  al.1 In an observational study of 107 patients with versus without cryptogenic stroke who were scheduled for percutaneous patent foramen ovale (PFO) closure, PFO anatomical characteristics were evaluated by transesophageal echocardiography. By developing a risk scoring system using these data, the authors concluded that high-risk PFO features on echocardiography are associated with a significantly increased risk of stroke. We commend the authors for their work, and in this letter, provide additional insight into the high-risk echocardiographic features of PFO that c...
Source: Journal of the American Society of Echocardiography - July 31, 2019 Category: Cardiology Authors: Mohammad K. Mojadidi, Muhammad O. Zaman, Fabian Nietlispach, Jonathan M. Tobis, Bernhard Meier Tags: Letter to the Editor Source Type: research

Bubble Test and Carotid Ultrasound to Guide Indication of Transesophageal Echocardiography in Young Patients With Stroke
CONCLUSIONS: Bubble test and carotid ultrasound could be used for the individual decision for/against TEE in patients with cryptogenic stroke ≤60 years. If they are unremarkable, TEE can be omitted with high safety regarding secondary prevention. If bubble test is positive and/or carotid ultrasound shows atherosclerosis, TEE should be carried out if PFO or aortic atheroma are potentially relevant for further patient management.PMID:35309558 | PMC:PMC8931264 | DOI:10.3389/fneur.2022.836609
Source: Atherosclerosis - March 21, 2022 Category: Cardiology Authors: Ernst Mayerhofer Dirk Kanz Brigitte Guschlbauer Christopher D Anderson Alexander Asmussen Sebastian Grundmann Christoph Strecker Andreas Harloff Source Type: research

Patent foramen ovale closure for recurrent stroke prevention: Recent evidence towards individualized decision-making
We read with great interest the meta-analysis by Piccolo and colleagues that showed a reduction in the recurrent stroke risk after patent foramen ovale (PFO) closure compared with medical therapy in patients with embolic stroke of unknown origin [1].
Source: International Journal of Cardiology - April 19, 2022 Category: Cardiology Authors: Akshay Goel, Mayank Singhal, Aaqib H. Malik, Rahul Gupta, Dhrubajyoti Bandyopadhyay Tags: Letter to the Editor Source Type: research

The Hype Surrounding Patent Foramen Ovale Closure and Cryptogenic Stroke: A Walk Through History
This article is the first of a multi-part review and will detail the history of PFO closure and the clinical trials that have evaluated the efficacy of PFO device closure. Data favour PFO closure in CS for reducing stroke in appropriate patients and should be considered as a treatment modality.PMID:36275353 | PMC:PMC9524620 | DOI:10.17925/HI.2022.16.1.59
Source: Heart International - October 24, 2022 Category: Cardiology Authors: Lekha Racharla Akhil Kher Zeel Patel Theresa Maitz Bryan Kluck Source Type: research