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Condition: Parkinson's Disease
Drug: Carbidopa/Levodopa

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Total 19 results found since Jan 2013.

A Kinematic Study of Progressive Micrographia in Parkinson's Disease
This study has investigated the kinematic features of progressive micrographia during a repetitive writing task. Twenty-four PD patients with duration since diagnosis of <10 years and 24 age-matched controls wrote the letter “e” repeatedly. PD patients were studied in defined off states, with scoring of motor function on the Unified Parkinson's Disease Rating Scale Part III. A digital tablet captured x-y coordinates and ink-pen pressure. Customized software recorded the data and offline analysis derived the kinematic features of pen-tip movement. The average size of the first and the last fi...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Cardiovascular and mortality risks in Parkinson's disease patients treated with entacapone
ABSTRACT The controlled trial Stalevo Reduction in Dyskinesia Evaluation in Parkinson's Disease (STRIDE‐PD) reported an unexpected increase in acute myocardial infarction (AMI) with entacapone use in patients with Parkinson's disease (PD). The authors investigated whether entacapone increased cardiovascular and mortality risk compared with the use of a non‐levodopa dopamine agonist (DA) or a selective monoamine oxidase type‐B inhibitor (MAOBI). Using national Medicare data, a new‐user cohort of elderly patients with PD treated with entacapone was propensity score (PS) matched with new users of either DA or MAOBI. T...
Source: Movement Disorders - February 26, 2013 Category: Neurology Authors: David J. Graham, James R. Williams, Ya‐Hui Hsueh, Katlyn Calia, Mark Levenson, Simone P. Pinheiro, Thomas E. MaCurdy, David Shih, Chris Worrall, Jeffrey A. Kelman Tags: Research Article Source Type: research

The effect of levodopa benserazide hydrochloride on homocysteinemia levels in patients with Parkinson's disease and treatment of hyperhomocysteinemia.
CONCLUSIONS: Oral administration of Levodopa in the treatment of PD can cause HHcy, which can result in increased occurrence of ischemic stroke. Supplementation of methylcobalamin and folic acid can effectively reduce Hcy level and thereby prevent the occurrence of ischemic stroke. PMID: 27338068 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Neuropathological Correlates of Visual Hallucinations in Parkinsonism (S03.006)
CONCLUSIONS: These findings suggest that Lewy-related pathology is specifically implicated in the genesis of VH in PD and related disorders. Plaque and tangles, although present in many cases, did not contribute to the occurrence of VH.Supported by: The Brain Donation Program is supported by the National Institute of Neurological Disorders and Stroke (U24 NS072026 National Brain and Tissue Resource for Parkinson's Disease and Related Disorders), the National Institute on Aging (P30 AG019610 Arizona Alzheimer's Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer's Research Cen...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Morshed, T., Jacobson, S., Beach, T., Adler, C., Shill, H., Caviness, J., Belden, C., Sue, L., Sabbagh, M., Hu, C., Davis, K. Tags: S03 Parkinson ' s Disease Source Type: research

Dopamine dysregulation syndrome in Parkinson's disease: from clinical and neuropsychological characterisation to management and long-term outcome
Conclusions Clinicians should be aware of risk factors predisposing to DDS. Duodenal levodopa infusion and, less consistently, STN-DBS were more commonly associated with DDS remission. Effective caregiving plays a key role in long-term behavioural outcome.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 6, 2014 Category: Neurosurgery Authors: Cilia, R., Siri, C., Canesi, M., Zecchinelli, A. L., De Gaspari, D., Natuzzi, F., Tesei, S., Meucci, N., Mariani, C. B., Sacilotto, G., Zini, M., Ruffmann, C., Pezzoli, G. Tags: JNNP Patients' choice, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Drugs misuse (including addiction) Movement disorders Source Type: research

Gender and Dopaminergic Medication Treatment in Early Parkinson Disease (P3.069)
CONCLUSIONS: Although we did not observe gender differences in the type and dose of dopaminergic treatment in LS-1 participants with early PD, further research is needed to evaluate gender influences on dopaminergic medication treatment in mid- and late-stage PD.Study Supported by: on behalf of the NET-PD LS1 investigators.Disclosure: Dr. Umeh has nothing to disclose. Dr. Pérez has nothing to disclose. Dr. Augustine has nothing to disclose. Dr. Dhall has received personal compensation for activities with UCP Pharma, Impax Pharmaceuticals, and Teva Neuroscience. Dr. Dewey has received personal compensation for activi...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Umeh, C., Perez, A., Augustine, E., Dhall, R., Dewey, R., Mari, Z., Simon, D., Wills, A. M., Christine, C., Schneider, J., Suchowersky, O. Tags: Movement Disorders: Clinical Features of Parkinson ' s Disease Source Type: research

Successful Management of Hemorrhage-associated Hemiballism after STN DBS with Pallidal Stimulation: A Case Report
Conclusion In our case pallidal DBS was effective in treating hemiballism that arose as a result of traumatic displacement of STN DBS electrodes. Medical management and changes in stimulation parameters failed to produce any significant change in the hemiballism. This report is only the third of its kind in the literature wherein hemiballism arising as a result of STN damage after DBS was successfully treated with pallidal stimulation.
Source: World Neurosurgery - July 10, 2015 Category: Neurosurgery Source Type: research

Parkinsonism, small vessel disease, and white matter disease: Is there a link?
Parkinsonian syndrome is primarily attributed to striato-nigral degeneration as idiopathic Parkinson disease (PD), although it can be caused by white matter (WM) disease as classically seen in vascular parkinsonism (VP). VP clinically manifests as predominant lower extremities involvement and gait impairment with poor response to levodopa and, radiologically, as WM hyperintensities (WMH) that disrupt the striato-nigral pathways. However, brain MRI vascular lesions correlate poorly with clinical manifestations and pathology findings.1
Source: Neurology - November 2, 2015 Category: Neurology Authors: Luca, C. C., Rundek, T. Tags: Parkinson's disease/Parkinsonism, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Patient Preferences for Device-Aided Treatments Indicated for Advanced Parkinsons Disease (APD) (P6.391)
Conclusions: Our findings suggest that patients, on average, prefer device aided treatments over oral therapy to improve movement symptoms in advanced PD, and that a portable infusion pump is preferred to DBS. Patient preferences are important and should be considered for therapeutic and access choices in advanced PD.Disclosure: Dr. Marshall has received personal compensation for activities with AbbVie, Inc. as an employee. Dr. Hauber has received research support from AbbVie. Dr. Fairchild has received research support from AbbVie. Dr. Sail has received personal compensation from AbbVie as an employee of the organization.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Marshall, T., Hauber, A. B., Fairchild, A., Sail, K. Tags: Movement Disorders: Parkinson ' s Disease II Source Type: research

Co-occurrence of cadasil and a parkinsonian syndrome: a report of two cases and review of the literature
Conclusions To our knowledge this represents the first autopsy-confirmed case of CADASIL with coexistent idiopathic Parkinson’s disease in a patient with a novel NOTCH3 mutation. We also report on a new genetically confirmed case of CADASIL presenting as progressive Parkinsonism.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Murray, N., Pepper, E., Blackie, J., Ronan, A., Sugo, E. Tags: Abstracts Source Type: research

Blood-brain barrier permeability in association with levodopa-induced dyskinesia in Parkinson's disease: a rubidium-82 PET study
Conclusion: The findings do not support the presence of significant alterations in BBB permeability in PD patients with or without LID. Research Support: This work was supported by the National Institute of Neurological Disorders and Stroke Morris K. Udall Center of Excellence for Parkinson’s Disease Research at The Feinstein Institute for Medical Research (P50 NS071675 to the last author).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Fujita, K., Dhawan, V., Peng, S., Ma, Y., Eidelberg, D. Tags: New Approaches to Image Parkinson Syndrome Source Type: research

Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes
Five years prior to TMS study, a 64 years old left-handed man with mild tremor-predominant Parkinson's disease that predominantly affected his right side experienced a large embolic left cerebellar infarct and subsequently required cerebellar hemispherectomy due to complications of cerebellar edema. He had no other evidence of brain lesions or stroke (Supplementary Figure). Patient was on Parkinson's medication Carbidopa/Levodopa 25 –100mg 3 times per day and denied having ON of OFF periods. Residual difficulties with coordination, speech, fine motor movements, spasticity and most prominently his balance led to the perma...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 22, 2018 Category: Neurology Authors: Isabelle Buard, Jean M. Berliner, Benzi M. Kluger Source Type: research

Vascular Parkinsonism sensitive to Rotigotine therapy is found in aged patients: a clinical case description.
Abstract Previous and recent papers have pointed out several discussions about the so called 'Vascular Parkinsonism' (VP), particularly about some distinctive characteristics with respect to the Idiopathic Parkinson Disease (IPD); differences commonly described are  sudden onset of extrapyramidal symptoms after a stroke, main involvement of lower limbs in diffuse brain microinfarcts (lower body parkinsonism), low, short in time or absent response to classic IPD therapy in all kinds of vascular brain pathologies. But few published studies have also emphasized some relationship linking brain morphological signs of ...
Source: Acta Bio-Medica : Atenei Parmensis - March 27, 2018 Category: General Medicine Authors: Zarola F Tags: Acta Biomed Source Type: research

Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes
Five years prior to TMS study, a 64 years old left-handed man with mild tremor-predominant Parkinson's disease that predominantly affected his right side experienced a large embolic left cerebellar infarct and subsequently required cerebellar hemispherectomy due to complications of cerebellar edema. He had no other evidence of brain lesions or stroke (Supplementary Figure). Patient was on Parkinson's medication Carbidopa/Levodopa 25 –100mg 3 times per day and denied having ON of OFF periods. Residual difficulties with coordination, speech, fine motor movements, spasticity and most prominently his balance led to the perma...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 22, 2018 Category: Neurology Authors: Isabelle Buard, Jean M. Berliner, Benzi M. Kluger Source Type: research

Sensory Re-weighting for Postural Control in Parkinson ’s Disease
In this study, we focused primarily on the change of sensory weighting parameters when sensory conditions change. We also tested the additional hypothesis that levodopa medication would improve sensory weighting for postural control. Materials and Methods Subjects The Institutional Review Board at Oregon Health and Science University (OHSU) approved the protocol for this experiment, and all subjects gave informed consent prior to participating. Eight subjects with PD (three female) and eight healthy, age-matched controls (two female) were recruited from the Balance Disorders Laboratory database and the Parkinson’...
Source: Frontiers in Human Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research