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Condition: Pain
Drug: Acetic Acid
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Total 267 results found since Jan 2013.
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking
Bioorg Chem. 2023 Sep 12;141:106847. doi: 10.1016/j.bioorg.2023.106847. Online ahead of print.ABSTRACTThe anti-inflammatory and analgesic drugs currently used are associated with several adverse effects and found to be highly unsafe for long-term use. Currently, nineteen novel bis-Schiff base derivatives (1-19) of flurbiprofen have been designed, prepared and assessed for in-vivo analgesic, anti-inflammatory and in vivo acute toxicity evaluation. The structures of the acquired compounds were deduced through modern spectroscopic techniques including HR-ESI-MS, 13C-, and 1H NMR. Amongst the series, compounds 7, 9, and 10 att...
Source: Bioorganic Chemistry - September 18, 2023 Category: Chemistry Authors: Aftab Alam Mumtaz Ali None Zainab Abdul Latif Najeeb Ur Rehman Abdul Jabbar Shah Irfan Amir Khan Muhammad Ayaz Sajjad Ur Rahman Ahmed Al-Harrasi Manzoor Ahmad Source Type: research
The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research
Anti-nociceptive and Anti-inflammatory Activities of Visnagin in Different Nociceptive and Inflammatory Mice Models
This study intends to explore the potential to treat pain by inhibiting nociception and inflammation with a safer, non-addictive, effective, and low-cost alternative agent from a natural source, visnagin. In vivo studies have been conducted using male Swiss albino mice as models for this research. Nociception was induced using different chemical and thermal stimuli such as acetic acid, glutamate, capsaicin, and formalin. To check for the anti-inflammatory properties, carrageenan was used to induce inflammation and the activity was assayed using peritoneal cavity leukocyte infiltration analysis and pro-inflammatory cytokine...
Source: Applied Biochemistry and Biotechnology - September 2, 2023 Category: Biochemistry Authors: Xiaobing Qi Kalaivani Aiyasamy Sattam Khulaif Alenezi Ibrahim M Alanazi Mohammed S Alshammari Ibrahim Abdel Aziz Ibrahim Source Type: research
The Efficacy of Oral Etoricoxib in Pain Control During Colposcopy-Directed Cervical Biopsy: A Randomized Control Trial
CONCLUSION: Administration of oral etoricoxib 30 minutes before colposcopy could reduce pain during and up to 24-hour post colposcopy with minimal side effects.PMID:37642074 | DOI:10.31557/APJCP.2023.24.8.2855
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Sarunya Sivapornpan Awassada Punyashthira Nopwaree Chantawong Pattra Wisarnsirirak Karicha Mairaing Yuthadej Thaweekul Yenrudee Poomtavorn Junya Pattaraarchachai Komsun Suwannarurk Source Type: research
Quercus floribunda Lindl. Ex A. Camus; a tremendous remedy against inflammation and associated symptoms
Fitoterapia. 2023 Jul 28:105628. doi: 10.1016/j.fitote.2023.105628. Online ahead of print.ABSTRACTCrude extracts prepared from aerial parts and nut galls of Quercus floribunda Lindl. Ex. A. Camus were evaluated for phytochemical screening, in vitro antioxidant, and in vivo analgesic, anti-inflammatory and antipyretic activities. Various solvents including methanol (M), acetone (A), distilled water (DW), distilled water + methanol (DWM) were used for extraction. Highest total phenolic (66.9 ± 0.05 μg GAE/mgE) and flavonoid content (38.4 ± 0.72 μg QE/mgE) were measured in QFAA extract by colorimetric methods. Cumulative ...
Source: Fitoterapia - July 30, 2023 Category: Biochemistry Authors: Fazilat Mehboob Ahmad Aroosa Zafar Madiha Ahmed Nausheen Akhtar Muhammad Mohtasheem Ul Hasan Mostafa A Abdel-Maksoude Mohammed Aufy Source Type: research
Vitexin inhibits pain and itch behavior via modulating TRPV4 activity in mice
This study aimed to explore the antinociceptive and anti-pruritic effects of MJS and whether its effects are mediated via the TRPV4 pathway. Mice were treated with MJS (7.5 mg/kg) 0.5 h prior to the initiation of the pain or itch modeling process. The results showed that MJS suppressed pain-like behavior in hot plate, thermal infiltration, glacial acetic acid twisting, and formalin tests. Administration of MJS decreased the pruritus response induced by histamine, C48/80, chloroquine and BAM8-22 within 30 min. MJS reduced scratching bouts and lessened the wiping reaction of mice under TRPV4 activation by GSK101 (10 µg/5 μ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2023 Category: Drugs & Pharmacology Authors: Zhiqiang Qin Lan Xiang Siyu Zheng Yuchen Zhao Yanyan Qin Lei Zhang Lanlan Zhou Source Type: research
Interventions for the symptoms and signs resulting from jellyfish stings
CONCLUSIONS: Few studies contributed data to this review, and those that did contribute varied in types of treatment, settings, and range of jellyfish species. We are unsure of the effectiveness of any of the treatments evaluated in this review given the very low certainty of all the evidence. This updated review includes two new studies (with 139 additional participants). The findings are consistent with the previous review.PMID:37272501 | PMC:PMC10240560 | DOI:10.1002/14651858.CD009688.pub3
Source: Cochrane Database of Systematic Reviews - June 5, 2023 Category: General Medicine Authors: Richard G McGee Angela C Webster Sharon R Lewis Michelle Welsford Source Type: research
< em > Lafoensia pacari < /em > alleviates intestinal damage by modulating cyclooxygenase-2: < em > In silico < /em > and < em > in vivo < /em > evaluation in a colitis model
CONCLUSION: The results of this study demonstrate a potential novel application of L. pacari extracts for the reduction of inflammation and promotion of antinociception/analgesia as demonstrated by our findings in a murine model of colitis. These findings were also corroborated by in silico analyses, and suggest that L. pacari extracts may be a promising therapeutic agent in the treatment of IBD.PMID:37213402 | PMC:PMC10198052 | DOI:10.3748/wjg.v29.i17.2628
Source: World Journal of Gastroenterology : WJG - May 22, 2023 Category: Gastroenterology Authors: Gabrielle Caroline Peiter Thayene Kamyli Moesch Queiroz Edson Luiz Michalkiewicz Raphael Henrique Chappuis Jennefer Sousa Luz Luiz Henrique Casagrande Piovezani Cleison Ferreira Silva Matheus Nozomi Tsutumi Augusto Fernandes Chaves Rafael Messias Luiz Cin Source Type: research
