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Specialty: Neurology
Condition: Multiple Sclerosis

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Total 440 results found since Jan 2013.

The Burden of Neurological Disease in the United States: A Summary Report and Call to Action
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - December 31, 2016 Category: Neurology Authors: Clifton L. Gooch, Etienne Pracht, Amy R. Borenstein Tags: Invited Editorial Source Type: research

The role of aquaporin-4 in synaptic plasticity, memory and disease.
Abstract Since the discovery of aquaporins, it has become clear that the various mammalian aquaporins play critical physiological roles in water and ion balance in multiple tissues. Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS, brain and spinal cord), has been shown to mediate CNS water homeostasis. In this review, we summarize new and exciting studies indicating that AQP4 also plays critical and unanticipated roles in synaptic plasticity and memory formation. Next, we consider the role of AQP4 in Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's...
Source: Brain Research Bulletin - March 4, 2017 Category: Neurology Authors: Hubbard JA, Szu JI, Binder DK Tags: Brain Res Bull Source Type: research

Severe recurrent neuroinflammation associated with cytotoxic T-lymphocyte antigen-4 (CTLA4) haploinsufficiency (P1.330)
Conclusions:CTLA4 mutations are associated with a distinct pattern of neuroinflammation. Supported by available pathology, the clinical-radiological discordance suggests that even large, enhancing lesions need not be destructive, even when behaving as space-occupying masses. Further characterization and modeling of this genetic disorder may provide insight into the mechanisms underlying other neuroimmunological disorders.Study Supported by: Fellowship funding from the National Multiple Sclerosis Society-American Brain Foundation. Intramural funds from the National Institute of Neurological Disorders and Stroke.Disclosure: ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Schindler, M., Pittaluga, S., Uzel, G., Reich, D., Cortese, I. Tags: CNS Inflammatory Diseases and Differential Diagnosis I Source Type: research

Patient-Reported Outcome Measurement in Manual Ability for Multiple Sclerosis: Addressing the Targeting Issues of the ABILHAND (P3.364)
Conclusions:Our study suggests that complementing the ABILHAND with bolt-on items appears to provide additional clinically relevant and targeted measurement of manual ability and related impact in early stage patients. To confirm this, ABILHAND along with new bolt-on items should be tested in a larger clinically-defined sample to evaluate its measurement properties (including measurement coverage and precision) in RRMS.Study Supported by: This study was funded by Biogen.Disclosure: Dr. Chen has received personal compensation for activities with Biogen as an employee. Dr. Chen holds stock and/or stock options in Biogen. Dr....
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chen, S.-Y., Pompilus, F., Strzok, S., Cleanthous, S., Cano, S., Marquis, P., Cohan, S., Goldman, M., Kresa-Reahl, K., Petrillo, J., Castrillo-Viguera, C., Cadavid, D., Mellion, M. Tags: Quality of Life, Symptoms and Symptomatic Therapy, Comorbidity, and Patient Reported Outcomes in Multiple Sclerosis Source Type: research

The Adult Spasticity International Registry (ASPIRE) Study: 1-Year Results (P4.034)
Conclusions:Findings demonstrate the real-world safety and effectiveness for onabotulinumtoxinA treatment in spasticity. Further analyses will explore clinical and burden outcomes and differences across etiology and presentation.Study Supported by: Allergan plcDisclosure: Dr. Francisco has received personal compensation for activities with Allergan, Ipsen, Mallinckrodt, and Merz. Dr. Francisco has received personal compensation in an editorial capacity for Journal of Rehabilitation Medicine. Dr. Francisco has received research support from Allergan, Ipsen, Mallinckrodt, Medtronic, Merz, Microtransponder, and Nexstim. Dr. B...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Francisco, G. E., Bandari, D. S., Bavikatte, G., Jost, W. H., Adams, A. M., Largent, J., Esquenazi, A. Tags: Neuro-rehabilitation: Motor Recovery and Spasticity Treatment Source Type: research

Maternal levels of Epstein-Barr virus IgG antibodies and risk of multiple sclerosis in offspring in the Finnish Maternity Cohort (S44.006)
Conclusions:Elevated maternal levels of VCA IgG are associated with an increased risk of MS in the offspring. Further studies are needed to elucidate potential biological mechanisms.Study Supported by: This study was funded by the National Institute of Neurological Disorders and Stroke (NIH R01 NS073633, PI: Ascherio).Disclosure: Dr. Munger has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Aivo has nothing to disclose. Dr. Hongell has nothing to disclose. Dr. Soilu-Hanninen has nothing to disclose. Dr. Surcel has nothing to disclose. Dr. Ascherio has received personal compensation for activities with Almirall...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Munger, K., Zhang, Z., Aivo, J., Hongell, K., Soilu-Hanninen, M., Surcel, H.-M., Ascherio, A. Tags: MS Risk Factors and Modifications Source Type: research

Music-based interventions in neurological rehabilitation
Publication date: Available online 26 June 2017 Source:The Lancet Neurology Author(s): Aleksi J Sihvonen, Teppo Särkämö, Vera Leo, Mari Tervaniemi, Eckart Altenmüller, Seppo Soinila During the past ten years, an increasing number of controlled studies have assessed the potential rehabilitative effects of music-based interventions, such as music listening, singing, or playing an instrument, in several neurological diseases. Although the number of studies and extent of available evidence is greatest in stroke and dementia, there is also evidence for the effects of music-based interventions on supporting cognition, motor...
Source: The Lancet Neurology - June 28, 2017 Category: Neurology Source Type: research

Review Music-based interventions in neurological rehabilitation
During the past ten years, an increasing number of controlled studies have assessed the potential rehabilitative effects of music-based interventions, such as music listening, singing, or playing an instrument, in several neurological diseases. Although the number of studies and extent of available evidence is greatest in stroke and dementia, there is also evidence for the effects of music-based interventions on supporting cognition, motor function, or emotional wellbeing in people with Parkinson's disease, epilepsy, or multiple sclerosis.
Source: Lancet Neurology - June 26, 2017 Category: Neurology Authors: Aleksi J Sihvonen, Teppo S ärkämö, Vera Leo, Mari Tervaniemi, Eckart Altenmüller, Seppo Soinila Tags: Review Source Type: research

Hospital safety among neurologic patients: A population-based cohort study of adverse events
Conclusions: This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Sauro, K. M., Quan, H., Sikdar, K. C., Faris, P., Jette, N. Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research

DR α1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury
AbstractTraumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated the ability of a molecular construct comprised of the human leukocyte antigen (HLA)-DR α1 domain linked covalently to mouse (m)MOG-35-55 peptide (DRα1-MOG-35-55 construct) to reduce CNS inflammation and tissue injury in animal models of multiple sclerosis and ischemic stroke. The aim of the current st...
Source: Metabolic Brain Disease - September 12, 2017 Category: Neurology Source Type: research

Comment A new era of multiple sclerosis rehabilitation: lessons from stroke
Just over 20 years ago, no treatments were available for multiple sclerosis, a disease characterised by two overlapping processes of nervous system injury: inflammatory destruction of myelin and neurodegeneration of grey and white matter.1 Disease-modifying drugs, particularly the new oral medications, have changed the prognosis of multiple sclerosis, contributing to increased periods of disease stability and greater potential for rehabilitative therapies to reduce impairment.2 In The Lancet Neurology, Robert Motl and colleagues3 argue that exercise can be a beneficial rehabilitation strategy for people with multiple scler...
Source: Lancet Neurology - September 13, 2017 Category: Neurology Authors: Michelle Ploughman Tags: Comment Source Type: research

A new era of multiple sclerosis rehabilitation: lessons from stroke
Publication date: October 2017 Source:The Lancet Neurology, Volume 16, Issue 10 Author(s): Michelle Ploughman
Source: The Lancet Neurology - September 13, 2017 Category: Neurology Source Type: research

Novel candidate genes of the PARK7 interactome as mediators of apoptosis and acetylation in multiple sclerosis: an in silico analysis
Conclusions Based on our results, novel potential target genes are revealed; these differentially expressed genes regulate epigenetic and apoptotic pathways that may further elucidate underlying mechanisms of autorreactivity in MS.
Source: Multiple Sclerosis and Related Disorders - October 24, 2017 Category: Neurology Source Type: research

Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient
We described a patient with cocaine abuse who presented with Balo's type acute multifocal leukoencephalopathy. Magnetic Resonance Imaging (MRI) of the brain showed onion like patchy concentric ring enhancement on T1-weighted MRI with gadolinium. Balo's Concentric Sclerosis like radiological findings related to cocaine has not been reported. Levamisole is now frequently used as an ingredient in cocaine and may cause leukoencephalopathy. It is recommended to check urine levamisole levels in patients with cocaine-induced leukoencephalopathy with or without mimicking Balo's Concentric Sclerosis. On the other hand, it is also p...
Source: Multiple Sclerosis and Related Disorders - December 16, 2017 Category: Neurology Source Type: research

Does restricted diffusion in the splenium indicate an acute infarct?
ConclusionNot every diffuse restriction observed on MRI indicates an ischemic stroke. Although radiologic images of the splenium may suggest acute ischemic infarction, the actual cause may be another pathology. Therefore, the symptoms and aetiologies of patients with splenium lesions should be considered and investigated from a wide range of perspectives.
Source: Acta Neurologica Belgica - January 6, 2018 Category: Neurology Source Type: research