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Specialty: Biochemistry
Condition: Multiple Sclerosis

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Total 48 results found since Jan 2013.

Protective features of peripheral monocytes/macrophages in stroke.
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger. PMID: 26584587 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 12, 2015 Category: Biochemistry Authors: Gliem M, Schwaninger M, Jander S Tags: Biochim Biophys Acta Source Type: research

Imaging of Neuroinflammation in Alzheimer's Disease, Multiple Sclerosis and Stroke: Recent Developments in Positron Emission Tomography.
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. PMID: 26643549 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 28, 2015 Category: Biochemistry Authors: Janssen B, Vugts DJ, Funke U, Molenaar GT, Kruijer PS, van Berckel BN, Lammertsma AA, Windhorst AD Tags: Biochim Biophys Acta Source Type: research

Paraoxonase 1 in neurological disorders.
Abstract Paroxonase 1 displays multiple physiological activities that position it as a putative player in the pathogenesis of neurological disorders. Here we reviewed the literature focusing on the role of paraoxonase 1 (PON1) as a factor in the risk of stroke and the major neurodegenerative diseases. PON1 activity is reduced in stroke patients, which significantly correlates inversely with carotid and cerebral atherosclerosis. The presence of the R allele of the Q192R PON1 polymorphism seems to potentiate this risk for stroke. PON1 exerts peroxidase activities that may be important in neurodegenerative disorders ...
Source: Redox Report : communications in free radical research - November 12, 2013 Category: Biochemistry Authors: Menini T, Gugliucci A Tags: Redox Rep Source Type: research

The role of the blood-brain barrier during neurological disease and infection
Biochem Soc Trans. 2023 Mar 17:BST20220830. doi: 10.1042/BST20220830. Online ahead of print.ABSTRACTA healthy brain is protected by the blood-brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain microenvironment and restricting pathogen and toxin entry to the brain. Dysfunction of this highly complex and regulated structure can be life threatening. BBB dysfunction is implicated in many neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis,...
Source: Biochemical Society Transactions - March 17, 2023 Category: Biochemistry Authors: Adjanie Patabendige Damir Janigro Source Type: research

The secretome of mesenchymal stem cells: Potential implications for neuroregeneration.
Abstract Mesenchymal stem cells have shown regenerative properties in many tissues. This feature had originally been ascribed to their multipotency and thus their ability to differentiate into tissue-specific cells. However, many researchers consider the secretome of mesenchymal stem cells the most important player in the observed reparative effects of these cells. In this review, we specifically focus on the potential neuroregenerative effect of mesenchymal stem cells, summarize several possible mechanisms of neuroregeneration and list key factors mediating this effect. We illustrate examples of mesenchymal stem ...
Source: Biochimie - July 19, 2013 Category: Biochemistry Authors: Paul G, Anisimov SV Tags: Biochimie Source Type: research

MicroRNA: Key regulators of oligodendrocyte development and pathobiology.
Abstract microRNAs (miRNAs or miRs) are a group of small non-coding RNAs that function through binding to messenger RNA (mRNA) targets and downregulating gene expression. miRs have been shown to regulate many cellular functions including proliferation, differentiation, development and apoptosis. Recently, evidence has grown which shows the involvement of miRs in oligodendrocyte (OL) specification and development. In particular, miRs-138, -219, -338, and -9 have been classified as key regulators of OL development, acting at various points in the OL lineage and influencing precursor cell transit into mature myelinat...
Source: The International Journal of Biochemistry and Cell Biology - May 27, 2015 Category: Biochemistry Authors: Fitzpatrick JM, Anderson RC, McDermott KW Tags: Int J Biochem Cell Biol Source Type: research

What have we learned about GPER function in physiology and disease from knockout mice?
Publication date: Available online 16 July 2015 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Eric R. Prossnitz, Helen J. Hathaway Estrogens, predominantly 17β-estradiol, exert diverse effects throughout the body in both normal and patho-physiology, during development and in reproductive, metabolic, endocrine, cardiovascular, nervous, musculoskeletal and immune systems. Estrogen and its receptors also play important roles in carcinogenesis and therapy, particularly for breast cancer. In addition to the classical nuclear estrogen receptors (ERα and ERβ) that traditionally mediate predomi...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 17, 2015 Category: Biochemistry Source Type: research

Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development
Publication date: Available online 2 October 2015 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Richa Hanamsagara, Staci D. Bilbob Several neurological conditions are associated with sex differences in prevalence or outcome. For example, autism predominantly affects boys, depression is more common in women, Parkinson's disease more common in men, and Multiple sclerosis in women. In the case of stroke, women have a less favorable outcome and suffer from a more precipitous drop in health status compared to men. As a result, treatment of such diseases is difficult and yields variable results....
Source: The Journal of Steroid Biochemistry and Molecular Biology - October 3, 2015 Category: Biochemistry Source Type: research

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease.
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger. PMID: 26499397 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - October 21, 2015 Category: Biochemistry Authors: Simon MJ, Iliff JJ Tags: Biochim Biophys Acta Source Type: research

Nudging Oligodendrocyte Intrinsic Signaling to Remyelinate and Repair: Estrogen Receptor Ligand Effects
Publication date: Available online 14 January 2016 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Anna J. Khalaj, Jonathan Hasselmann, Catherine Augello, Spencer Moore, Seema K. Tiwari-Woodruff Demyelination in multiple sclerosis (MS) leads to significant, progressive axonal and neuronal degeneration. Currently existing immunosuppressive and immunomodulatory therapies alleviate MS symptoms and slow, but fail to prevent or reverse, disease progression. Restoration of damaged myelin sheath by replenishment of mature oligodendrocytes (OLs) should not only restore saltatory axon conduction, ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 15, 2016 Category: Biochemistry Source Type: research

Neuroprotectant androst-3 β, 5α, 6β-triol suppresses TNF-α-induced endothelial adhesion molecules expression and neutrophil adhesion to endothelial cells by attenuation of CYLD-NF-κB pathway.
Neuroprotectant androst-3β, 5α, 6β-triol suppresses TNF-α-induced endothelial adhesion molecules expression and neutrophil adhesion to endothelial cells by attenuation of CYLD-NF-κB pathway. Biochem Biophys Res Commun. 2017 Jan 09;: Authors: Yan M, Leng T, Tang L, Zheng X, Lu B, Li Y, Sheng L, Lin S, Shi H, Yan G, Yin W Abstract Neuroinflammation is one of key pathologic element in neurological diseases including stroke, traumatic brain injury, Alzheimer' s Disease, Parkinson's Disease, and multiple sclerosis as well. Up-regulation of endothelial adhesion molecules, which facilitate leukocyte adh...
Source: Biochemical and Biophysical Research communications - January 8, 2017 Category: Biochemistry Authors: Yan M, Leng T, Tang L, Zheng X, Lu B, Li Y, Sheng L, Lin S, Shi H, Yan G, Yin W Tags: Biochem Biophys Res Commun Source Type: research

IFN- γ, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: Relevance for neuro-inflammatory diseases.
IFN-γ, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: Relevance for neuro-inflammatory diseases. Biochem Biophys Res Commun. 2018 Nov 15;: Authors: Rahman MT, Ghosh C, Hossain M, Linfield D, Rezaee F, Janigro D, Marchi N, van Boxel-Dezaire AHH Abstract Breakdown of the blood-brain barrier (BBB) precedes lesion formation in the brains of multiple sclerosis (MS) patients. Since recent data implicate disruption of the small intestinal epithelial barrier (IEB) in the pathogenesis of MS, we hypothesized that the increased permeability of t...
Source: Biochemical and Biophysical Research communications - November 15, 2018 Category: Biochemistry Authors: Rahman MT, Ghosh C, Hossain M, Linfield D, Rezaee F, Janigro D, Marchi N, van Boxel-Dezaire AHH Tags: Biochem Biophys Res Commun Source Type: research

Benefits of curcumin in brain disorders
AbstractCurcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti ‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This...
Source: BioFactors - June 10, 2019 Category: Biochemistry Authors: Abid Bhat, Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Tousif A. Hediyal, Esther Manthiannem, Jagadeeswari Padamati, Ramesh Chandra, Saravana B. Chidambaram, Meena K. Sakharkar Tags: REVIEW ARTICLE Source Type: research