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Total 888 results found since Jan 2013.

The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease
CONCLUSION: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.PMID:35853549 | DOI:10.1016/j.arr.2022.101698
Source: Ageing Research Reviews - July 19, 2022 Category: Genetics & Stem Cells Authors: Tibor Hortob ágyi Tomas Vetrovsky Guilherme Moraes Balbim N árlon Cássio Boa Sorte Silva Andrea Manca Franca Deriu Mia Kolmos Christina Kruuse Teresa Liu-Ambrose Zsolt Rad ák M árk Váczi Hanna Johansson Paulo Cezar Rocha Dos Santos Erika Franz én U Source Type: research

Feasibility, Acceptability, and Efficacy of Mindfulness Training in People with Upper Motor Neuron Disorders: A Systematic Review
CONCLUSION: Based on current data, MBIs are feasible and offer a promising approach to address the biopsychosocial needs of individuals with UMNDs. MBIs are associated with a high acceptance rate among participants with notable improvements in depression, anxiety, fatigue, and quality of life post-intervention. Future studies are needed to evaluate alternate models of delivery of MBIs and the dose-response relationship.PMID:35760105 | DOI:10.1016/j.apmr.2022.05.020
Source: Health Physics - June 27, 2022 Category: Physics Authors: Radha Korupolu Aila Malik Chelsea Ratcliff Susan Robinson-Whelen Heather B Taylor Source Type: research

CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells
Discussion CNS autoantigen-specific autoimmunity has a protective influence on primary tissue damage after experimental stroke, indicating a very early involvement of CNS antigen-specific, myeloid cell-associated anti-inflammatory immune mechanisms that mitigate ischemic injury in the acute EAE phase.
Source: Neurology Neuroimmunology and Neuroinflammation - June 8, 2022 Category: Neurology Authors: Guse, K., Hagemann, N., Thiele, L., Remlinger, J., Salmen, A., Hoepner, R., Keller, I., Meyer, P., Grandgirard, D., Leib, S. L., Vassella, E., Locatelli, G., Hermann, D. M., Chan, A. Tags: All Immunology, Multiple sclerosis, Infarction Research Article Source Type: research

A Comprehensive Review on Therapeutic Potential of Chrysin in Brain Related Disorders
This study depicts the relationship of chrysin with different brain related disorders and discusses the mechanisms responsible for the potential role of chrysin as a pharmacological agent for the treatment and management of different brain disorders, based on the results of several preclinical studies and taking into account the therapeutic effects of the compound.PMID:35657041 | DOI:10.2174/1871527321666220602111935
Source: CNS and Neurological Disorders Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Ahsas Goyal Geetanjali Singh Aanchal Verma Source Type: research

Safety and Clinical Efficacy of Mesenchymal Stem Cell Treatment in Traumatic Spinal Cord Injury, Multiple Sclerosis and Ischemic Stroke – A Systematic Review and Meta-Analysis
BackgroundMesenchymal stem cells (MSCs) is an attractive candidate in regenerative research and clinical trials have assessed their therapeutic potential in different neurological conditions with disparate etiologies. In this systematic review, we aimed to assess safety and clinical effect of MSC treatment in traumatic spinal cord injury (TSCI), multiple sclerosis (MS) and ischemic stroke (IS).MethodsA systematic search was performed 2021-12-10 in MEDLINE, EMBASE, Web of Science and Cochrane where clinical studies assessing MSC treatment in TSCI, MS or IS were included. Studies without control group were excluded for effic...
Source: Frontiers in Neurology - May 30, 2022 Category: Neurology Source Type: research

Experiences of individuals with multiple sclerosis and stroke using transcutaneous foot drop electrical stimulators: a systematic review and meta-synthesis of qualitative studies
CONCLUSIONS: We recommend that the outcomes to continued use of foot drop electrical stimulators are carefully considered against the barriers. Our conceptual model may be useful to guide clinical conversations around the possible use of FES for managing foot drop in people with multiple sclerosis and stroke.Implications for rehabilitationThe key outcomes to foot drop electrical stimulator use were enhanced walking ability, improved independence and confidence, and enhanced social participation.The main barriers to foot drop electrical stimulator use were device aesthetics, usability challenges, trustworthiness of device i...
Source: Disability and Rehabilitation - May 24, 2022 Category: Rehabilitation Authors: Felicity Burns Allyson Calder Hemakumar Devan Source Type: research

Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases
Transcranial Magnetic Stimulation (TMS) has widespread use in research and clinical application. For psychiatric applications, such as depression or OCD, repetitive TMS protocols (rTMS) are an established and globally applied treatment option. While promising, rTMS is not yet as common in treating neurological diseases, except for neurorehabilitation after (motor) stroke and neuropathic pain treatment. This may soon change. New clinical studies testing the potential of rTMS in various other neurological conditions appear at a rapid pace. This can prove challenging for both practitioners and clinical researchers. Although m...
Source: Frontiers in Neurology - May 20, 2022 Category: Neurology Source Type: research

Imaging subtle leaks in the blood –brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions
AbstractRecent studies using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium-based contrast agents (GBCA) have demonstrated subtle blood –brain barrier (BBB) leaks in the human brain during normal aging, in individuals with age-related cognitive dysfunction, genetic risk for Alzheimer’s disease (AD), mild cognitive impairment, early AD, cerebral small vessel disease (SVD), and other neurodegenerative disorders. In these neurologi cal conditions, the BBB leaks, quantified by the unidirectional BBB GBCA tracer’s constantKtrans maps, are typically orders of magnitude lower than in brain tu...
Source: AGE - April 25, 2022 Category: Geriatrics Source Type: research

A systematic review on extracorporeal shock wave therapy and botulinum toxin for spasticity treatment: a comparison on efficacy
CONCLUSIONS: A beneficial effect on spasticity was found for both treatments: evidence showed that ESWT and BoNT-A can ameliorate spasticity considering parameters such as MAS, MTS, AROM, PROM, UE-FMA, VAS and SFS in post-stroke, multiple sclerosis, and cerebral palsy patients. Further research is required to strengthen the evidence, and more suitable study protocols are highly needed.PMID:35412036 | DOI:10.23736/S1973-9087.22.07136-2
Source: European Journal of Physical and Rehabilitation Medicine - April 12, 2022 Category: Rehabilitation Authors: Emanuela E Mihai Marius N Popescu Alina N Iliescu Mihai Berteanu Source Type: research