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Thrombolytic Treatment for Acute Ischemic Stroke Patients with History of Migraine Headaches (P4.223)
Conclusion: Patients with migraine headaches receiving IV rt-PA treatment for acute ischemic stroke appear to have a lower rates of death and disability most likely related to their decreased rates of intracerebral hemorrhage.Disclosure: Dr. Malik has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Nickles has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Malik, A., Adil, M., Chaudhry, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Stroke and nonstroke brain attacks in children
Conclusions: Brain attack etiologies differ from adults, with stroke being the fourth most common diagnosis. These findings will inform development of ED clinical pathways for pediatric brain attacks.
Source: Neurology - April 21, 2014 Category: Neurology Authors: Mackay, M. T., Chua, Z. K., Lee, M., Yock-Corrales, A., Churilov, L., Monagle, P., Donnan, G. A., Babl, F. E. Tags: Childhood stroke, All Cerebrovascular disease/Stroke, All Pediatric, Prevalence studies ARTICLE Source Type: research

Stroke Mimics under the Drip-and-Ship Paradigm
Conclusion: The drip-and-ship paradigm and any psychiatric history predict the diagnosis of SM. None of the SM had thrombolysis-related complications, and all were discharged to home. These findings may explain the superior outcomes associated with the drip-and-ship paradigm in the treatment for AIS.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Sonal Mehta, Nirav Vora, Randall C. Edgell, Hesham Allam, Aws Alawi, Jennifer Koehne, Abhay Kumar, Eliahu Feen, Salvador Cruz-Flores, Amer Alshekhlee Tags: Original Articles Source Type: research

Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice Basic Sciences
Conclusions— These data underscore the importance of hyperexcitability as a mechanism for increased stroke risk in migraineurs, and suggest that migraine prophylaxis may not only prevent migraine attacks but also protect migraineurs against ischemic injury.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Eikermann-Haerter, K., Lee, J. H., Yalcin, N., Yu, E. S., Daneshmand, A., Wei, Y., Zheng, Y., Can, A., Sengul, B., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Ayata, C. Tags: Neuroprotectors Basic Sciences Source Type: research

Exploring Protein Quantitation Methods to Detect Useful Plasma Biomarkers for Distinguishing Ischemic Stroke from Mimic (I2.013)
Conclusions: These results provide proof of concept that proteomic signals can be useful in ACVS diagnosis in more severe cases.The analyses have shaped our prospective verification (completed, n=560) and validation studies (ongoing, n=1200) of the use of proteomics in the diagnosis of mimic vs. mild-ACVS in early Emergency Department triage.Disclosure: Dr. Penn has received personal compensation for activities with Pfizer, Boehringer Ingelheim Pharmaceuticals, Inc., and Bayer as a speaker. Dr. Balshaw has nothing to disclose. Dr. Lesperance has nothing to disclose. Dr. Saly has nothing to disclose. Dr. Jackson has nothing...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Penn, A., Balshaw, R., Lesperance, M., Saly, V., Jackson, A., Smith, D., Votova, K., Lu, L., Morrison, J., Coutts, S., Borchers, C. Tags: Stroke in the Elderly and Young: Challenges for the Next Decade Poster Presentations Source Type: research

Moyamoya and childhood stroke: Catching up with Tyler and Ryan
Ryan (above left) and Tyler Earle of Winnipeg, Canada had a ticking time bomb inside their heads. Both boys have a rare brain disorder called moyamoya that had caused the arteries feeding their brains to become dangerously narrowed. At first, they experienced only headaches. But then Ryan suddenly lost his ability to write, began having trouble with word-finding and became weak on one side of his body — signs he had suffered a stroke. He was diagnosed with moyamoya and had partial surgery, but a second stroke took away part of his vision and partially paralyzed him. Ryan needed a second operation as soon as possible. By ...
Source: Thrive, Children's Hospital Boston - May 12, 2016 Category: Pediatrics Authors: Nancy Fliesler Tags: Diseases & Conditions Cerebrovascular Disorders and Stroke Program Dr. Edward Smith moyamoya Source Type: news

Risk of Carotid Stroke after Chiropractic Care: A Population-Based Case-Crossover Study
Chiropractic manipulation is a popular treatment for neck pain and headache, but may increase the risk of cervical artery dissection and stroke. Patients with carotid artery dissection can present with neck pain and/or headache before experiencing a stroke. These are common symptoms seen by both chiropractors and primary care physicians (PCPs). We aimed to assess the risk of carotid artery stroke after chiropractic care by comparing association between chiropractic and PCP visits and subsequent stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 20, 2016 Category: Neurology Authors: J. David Cassidy, Eleanor Boyle, Pierre C ôté, Sheilah Hogg-Johnson, Susan J. Bondy, Scott Haldeman Source Type: research

Variation in Knowledge of Stroke Warning Signs by Age and Presence of Conventional Risk Factors: A Community Health Survey in Korea
Conclusion Stoke risk factors are increasing among young people; they still have poor knowledge about SWSs. More education is needed to increase appropriate treatment, especially in young people with stroke-related risk factors.
Source: Journal of Cardiovascular Nursing - February 11, 2022 Category: Nursing Tags: ARTICLES: Stroke Care Source Type: research

A stroke mimic; focal neurological deficits in benign hereditary chorea?
Conclusion This case highlights the difficulties in assessing patients with new focal neurological symptoms in the presence of known, pre existing, neurological disease. It also serves to highlight how often erroneously progressive weakness is mislabelled as a ‘stroke’. Neurologists working together with acute physicians in liaison posts in MAU, provides a unique opportunity to improve overall recognition of neurological disease, and for patients potentially provides a more timely diagnostic work–up and the opportunity for early treatment.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Maw, K., Johnston, J., Rowntree, C., Kalhan, A. Tags: Immunology (including allergy), Headache (including migraine), Movement disorders (other than Parkinsons), Neurooncology, Pain (neurology), Stroke, CNS cancer, Neuropathology, Radiology, Surgical diagnostic tests, Surgical oncology Association of Britis Source Type: research

Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis. First report from the Italian Registry of Pediatric Thrombosis (R. I. T. I., Registro Italiano Trombosi Infantili).
I. T. I. (Registro Italiano Trombosi Infantili) Abstract Data from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral throm...
Source: Thrombosis and Haemostasis - March 12, 2015 Category: Hematology Authors: Suppiej A, Gentilomo C, Saracco P, Sartori S, Agostini M, Bagna R, Bassi B, Giordano P, Grassi M, Guzzetta A, Lasagni D, Luciani M, Molinari AC, Palmieri A, Putti MC, Ramenghi LA, Rota LL, Sperlì D, Laverda AM, Simioni P, Stroke working group of the R.†Tags: Thromb Haemost Source Type: research

Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants
Conclusions: Our findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms. Our observations on MA are consistent with a limited role of common genetic variants in this subtype.
Source: Neurology - May 25, 2015 Category: Neurology Authors: Malik, R., Freilinger, T., Winsvold, B. S., Anttila, V., Vander Heiden, J., Traylor, M., de Vries, B., Holliday, E. G., Terwindt, G. M., Sturm, J., Bis, J. C., Hopewell, J. C., Ferrari, M. D., Rannikmae, K., Wessman, M., Kallela, M., Kubisch, C., Fornage, Tags: Migraine, All Cerebrovascular disease/Stroke, Case control studies, All Genetics, Association studies in genetics ARTICLE Source Type: research

Migraine makes the stroke grow faster?
Long associated with increased incidence of stroke,1,2 migraine has been linked with mechanisms involving the vasculature (vasospasm, arterial dissection, endothelial dysfunction, venous thrombosis), heart (patent foramen ovale), and blood (hypercoagulability).3 Since cerebral ischemia can induce cortical spreading depression, the physiologic process underlying aura, migraine with aura may theoretically represent a TIA equivalent in a subset of people. In addition to the heightened occurrence of stroke in migraineurs, a growing body of evidence suggests more dire consequences when stroke occurs, with experiments in mice wi...
Source: Neurology - November 30, 2015 Category: Neurology Authors: Tietjen, G. E., Sacco, S. Tags: Migraine, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Post-IV thrombolytic headache and hemorrhagic transformation risk in acute ischemic stroke
Conclusion: tPA-associated headache does not predict increased risk of HT and has no other prognostic importance in patients with AIS. Prospective studies with a larger cohort may be needed to further explore this relationship.
Source: Neurology Clinical Practice - February 15, 2016 Category: Neurology Authors: Chaudhry, S. A., Kwon, S. Y., Kneale, H., Al Jajeh, A., Hussain, S., Razak, A. Tags: All Cerebrovascular disease/Stroke, Embolism, Intracerebral hemorrhage Research Source Type: research

Prothrombotic State in Patients With a Left Atrial Appendage Thrombus of Unknown Origin and Cerebrovascular Events Clinical Sciences
Conclusions— Prothrombotic blood alterations could be involved in the LAA thrombus formation in patients without documented atrial fibrillation and are associated with increased risk of stroke or transient ischemic attack during follow-up.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Meus, R., Son, M., Sobczyk, D., Undas, A. Tags: Ischemic Stroke Clinical Sciences Source Type: research

Vulnerability to Infarction During Cerebral Ischemia in Migraine Sufferers Clinical Sciences
Conclusions—Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Alessandro Pezzini, Giorgio Busto, Marialuisa Zedde, Massimo Gamba, Andrea Zini, Loris Poli, Filomena Caria, Valeria De Giuli, Anna Maria Simone, Rosario Pascarella, Alessandro Padovani, Marina Padroni, Roberto Gasparotti, Stefano Colagrande, Enrico Faina Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Ischemic Stroke, Vascular Disease Original Contributions Source Type: research