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Total 54 results found since Jan 2013.

Abstract 4217: Nuclear expression of BCL10 has a role in the regulation of cell growth and progression of pancreatic cancer through the activation of NF-{kappa}B-related signaling
Background: We previously reported that activation of TNF-α results in upregulation of NF-κB and nuclear translocation of BCL3 and BCL10 in breast cancer cell line and lymphoma cell line (J Biol Chem 2006;281:167-75, Blood 2008;112:2927-34). Furthermore, we recently demonstrated that BCL10 plays an important role in controlling the growth of cervical cancer cells through NF-κB dependent cyclin D1 regulation (Gynecol Oncol 2012;126:245-51). Since NF-κB activation has been shown to occur in the pathogenesis of pancreatic cancer, we sought to investigate whether BCL10-signaling possesses clinical significance in relation ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Kuo, S.-H., Yang, S.-H., Yeh, K.-H., Yeh, P.-Y., Tien, Y.-W., Lee, H.-W., Chen, L.-T., Cheng, A.-L. Tags: Molecular and Cellular Biology Source Type: research

Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research

Effect of TET1 regulating MGMT on chemotherapy resistance of oral squamous cell carcinoma stem cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - June 23, 2017 Category: Biochemistry Authors: Wei Wang, Xin Li, Fan Wang, Xiang ‐Yu Sun Tags: Article Source Type: research

TR3 modulates platinum resistance in ovarian cancer.
Abstract In metastatic ovarian cancer, resistance to platinum chemotherapy is common. Although the orphan nuclear receptor TR3 (nur77/NR4A1) is implicated in mediating chemotherapy-induced apoptosis in cancer cells, its role in ovarian cancer has not been determined. In an ovarian cancer tissue microarray, TR3 protein expression was elevated in stage I tumors, but down-regulated in a significant subset of metastatic tumors. Moreover, TR3 expression was significantly lower in platinum-resistant tumors in patients with metastatic disease, and low TR3 staining was associated with poorer overall and progression-free s...
Source: Cell Research - May 29, 2013 Category: Cytology Authors: Wilson AJ, Liu AY, Roland JT, Adebayo OB, Fletcher SA, Slaughter JC, Saskowski J, Crispens MA, Jones HW, James S, Fadare O, Khabele D Tags: Cancer Res Source Type: research

Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway
This study may provide a rationale for future clinical application using arenobufagin as a chemotherapeutic agent for HCC.
Source: Carcinogenesis - June 3, 2013 Category: Cancer & Oncology Authors: Zhang, D.-M., Liu, J.-S., Deng, L.-J., Chen, M.-F., Yiu, A., Cao, H.-H., Tian, H.-Y., Fung, K.-P., Kurihara, H., Pan, J.-X., Ye, W.-C. Tags: Original Manuscript Source Type: research

TR3 Dysfunction in Ovarian Cancer
In metastatic ovarian cancer, resistance to platinum chemotherapy is common. Although the orphan nuclear receptor TR3 (nur77/NR4A1) is implicated in mediating chemotherapy-induced apoptosis in cancer cells, its role in ovarian cancer has not been determined. In an ovarian cancer tissue microarray, TR3 protein expression was elevated in stage I tumors, but downregulated in a significant subset of metastatic tumors. Moreover, TR3 expression was significantly lower in platinum-resistant tumors in patients with metastatic disease, and low TR3 staining was associated with poorer overall and progression-free survival. We have id...
Source: Cancer Research - July 31, 2013 Category: Cancer & Oncology Authors: Wilson, A. J., Liu, A. Y., Roland, J., Adebayo, O. B., Fletcher, S. A., Slaughter, J. C., Saskowski, J., Crispens, M. A., Jones, H. W., James, S., Fadare, O., Khabele, D. Tags: Molecular and Cellular Pathobiology Source Type: research

WEE1 Is Regulated by HuR upon DNA Damage
We describe a novel mechanism that PDA cells use to protect against DNA damage in which HuR posttranscriptionally regulates the expression and downstream function of WEE1 upon exposure to DNA-damaging agents. Cancer Res; 74(4); 1128–40. ©2014 AACR.
Source: Cancer Research - February 16, 2014 Category: Cancer & Oncology Authors: Lal, S., Burkhart, R. A., Beeharry, N., Bhattacharjee, V., Londin, E. R., Cozzitorto, J. A., Romeo, C., Jimbo, M., Norris, Z. A., Yeo, C. J., Sawicki, J. A., Winter, J. M., Rigoutsos, I., Yen, T. J., Brody, J. R. Tags: Molecular and Cellular Pathobiology Source Type: research

Parthenolide Inhibits Cancer Stem-Like Side Population of Nasopharyngeal Carcinoma Cells via Suppression of the NF-κB/COX-2 Pathway
In this study, cyclooxygenase-2 (COX-2) was found to regulate cancer stem-like side population cells of nasopharyngeal carcinoma cells and enhance cancer stem-like cells' characteristics such as higher colony formation efficiency and overexpression of stemness-associated genes. The regulatory effect of COX-2 on cancer stem-like characteristics may be mediated by ABCG2. COX-2 overexpression by a gain-of-function experiment increased the proportion of side population cells and their cancer stemness properties. The present study also demonstrated that in contrast to the classical chemotherapy drug 5-fluorouracil, which increa...
Source: Theranostics - January 1, 2015 Category: Molecular Biology Authors: Kun Liao, Bin Xia, Qun-Ying Zhuang, Meng-Jun Hou, Yu-Jing Zhang, Bing Luo, Yang Qiu, Yan-Fang Gao, Xiao-Jie Li, Hui-Feng Chen, Wen-Hua Ling, Cheng-Yong He, Yi-Jun Huang, Yu-Chun Lin, Zhong-Ning Lin Tags: Research Paper Source Type: research

ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1
Conclusions: ZBP-89 attenuates HDAC3 by increasing I?B degradation. Such attenuation is independent of NF-?B activity but partially depends on Pin1. The novel pathway identified may help generate new anti-cancer strategy by targeting HDAC3 and its related molecules.
Source: Journal of Translational Medicine - January 27, 2015 Category: Research Authors: Cai YeLiping LiuGeorge ChenXiao TangZhiwei HeMing-Liang HePaul Lai Source Type: research

AMPK activation by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib
This article is protected by copyright. All rights reserved.
Source: Cancer Science - February 12, 2015 Category: Cancer & Oncology Authors: Naoki Ishijima, Keita Kanki, Hiroki Shimizu, Goshi Shiota Tags: Original Article Source Type: research

Activation of AMP‐activated protein kinase by retinoic acid sensitizes hepatocellular carcinoma cells to apoptosis induced by sorafenib
In this study, we investigated the effects of combined treatment using sorafenib and retinoids including all‐trans retinoic acid (ATRA), NIK‐333, and Am80 on HCC cells. Cell viability assays in six HCC cell lines, HepG2, PLC/PRF/5, HuH6, HLE, HLF, and Hep3B, revealed that 5 and 10 μM ATRA, concentrations that do not exert cytotoxic effects, enhanced the cytotoxicity of sorafenib, being much more effective than NIK‐333 and Am80. We found that ATRA induced AMP‐activated protein kinase activation, which was followed by reduced intracellular ATP level. Gene expression analysis revealed that ATRA decreased the express...
Source: Cancer Science - March 9, 2015 Category: Cancer & Oncology Authors: Naoki Ishijima, Keita Kanki, Hiroki Shimizu, Goshi Shiota Tags: Original Article Source Type: research