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Body structure/function impairments and activity limitations of post-stroke that predict social participation: a systematic review
CONCLUSION: There is some evidence that stroke severity, mental and motor deficits, limitations in activities of daily living and the ability to walk after a stroke can predict social participation in the community. PROSPERO registration CRD42020177591.PMID:35787246 | DOI:10.1080/10749357.2022.2095086
Source: Topics in Stroke Rehabilitation - July 5, 2022 Category: Neurology Authors: Flaviane Ribeiro de Souza Matheus Sales Larrie Rabelo Laporte Ailton Melo Nildo Manoel da Silva Ribeiro Source Type: research

Neutrophil Extracellular Traps (NETs): A New Therapeutic Target for Neuroinflammation and Microthrombosis After Subarachnoid Hemorrhage?
AbstractNeutrophil extracellular traps (NETs) play a major role in intrinsic immunity by limiting and killing pathogens. Recently, a series of studies have confirmed that NETs are closely associated with vascular injury and microthrombosis. Furthermore, NETs play an important role in neuroinflammation after ischemic and hemorrhagic stroke. Neuroinflammation and microthrombosis after subarachnoid hemorrhage are key pathophysiological processes associated with poor prognosis, but their crucial formation mechanisms and interventions remain to be elucidated. Could NETs, as an emerging and important pathogenesis, be a new thera...
Source: Translational Stroke Research - June 11, 2022 Category: Neurology Source Type: research

Procedural and Methodological Quality in Preclinical Stroke Research –A Cohort Analysis of the Rat MCAO Model Comparing Periods Before and After the Publication of STAIR/ARRIVE
In conclusion, the frequency of periinterventional monitoring has decreased over time. Some general methodological quality aspects, however, partially have increased. CBF measurement–the gold standard for ischemia verification-was applied rarely. Despite the growing recognition of current guidelines such as STAIR and ARRIVE (both widely approved in 2019) reporting, methods and procedures mostly do not follow these guidelines. These deficits may contribute to the translational failure of preclinical stroke research in search for neuroprotective therapies.
Source: Frontiers in Neurology - May 30, 2022 Category: Neurology Source Type: research

Scoring System to Predict Hospital Outcome After Subarachnoid Hemorrhage –Incorporating Systemic Response: The CRIG Score
Aneurysmal subarachnoid hemorrhage (aSAH) causes acute brain injury by deranging brain's microenvironment and has several systemic effects.1 Deleterious effects of acute brain injury after aSAH are manifested locally as early brain injury (EBI) and delayed cerebral ischemia (DCI).1 Pathological events like EBI and DCI both contribute to morbidity and mortality associated with aSAH. These local physiological derangements are difficult to study in vivo in humans and hence, investigators often rely on serological biomarkers to predict EBI and DCI after aSAH.
Source: Journal of Stroke and Cerebrovascular Diseases - May 24, 2022 Category: Neurology Authors: Mausaminben Y. Hathidara, Yesica Campos, Swathy Chandrashekhar, Chao Xu, DaiWai M. Olson, Aardhra Venkatachalam, Bappaditya Ray Source Type: research

Thioredoxin 1 regulates the pentose phosphate pathway via ATM phosphorylation after experimental subarachnoid hemorrhage in rats
Brain Res Bull. 2022 May 16;185:162-173. doi: 10.1016/j.brainresbull.2022.05.008. Online ahead of print.ABSTRACTSubarachnoid hemorrhage (SAH), a type of hemorrhagic stroke, is a neurological emergency with high morbidity and mortality. Early brain injury (EBI) after SAH is the leading cause of poor prognosis in SAH patients. TRX system is a NADPH-dependent antioxidant system which is composed of thioredoxin reductase (TRXR), thioredoxin (TRX). The pentose phosphate pathway (PPP), a pathway through which glucose can be metabolized, is a major source of NADPH. Thioredoxin 1 (TRX1) is a member of thioredoxin system mainly loc...
Source: Brain Research Bulletin - May 19, 2022 Category: Neurology Authors: Xiaodong Wang Zongqi Wang Jie Wu Lingling Wang Xiang Li Haitao Shen Haiying Li Jianguo Xu Wen Li Gang Chen Source Type: research

A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score
This study aimed to establish a new scoring model based on the early brain injury (EBI) indicators to predict the 90-day functional outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). We retrospectively enrolled 825 patients and prospectively enrolled 108 patients with aSAH who underwent surgical clipping or endovascular coiling (derivation cohort  = 640; validation cohort = 185; prospective cohort = 108) in our institute. We established a logistic regression model based on independent risk factors associated with 90-day unfavorable outcomes. The discrimination of the prognostic model was asses...
Source: Translational Stroke Research - May 14, 2022 Category: Neurology Source Type: research

Clostridium difficile Infection Does Not Impact Outcomes in Stroke Patients
This study investigates incidence, patient characteristics, clinical features, and outcomes of CDI following stroke, including ischemic stroke (IS), intracerebral hemorrhage (ICH), and aneurysmal subarachnoid hemorrhage (SAH). Methods: The hospital database was queried for all patients with IS, ICH, or SAH from 2010 through 2014. Patients who underwent testing for C. difficile testing (CDT) through polymerase chain reaction were assessed. Demographics, risk factors, clinical features, and outcomes were recorded. Fever was defined as temperature>101°F. Results: CDT was obtained in 555/4004 patients and was po...
Source: The Neurologist - May 1, 2022 Category: Neurology Tags: Original Articles Source Type: research

Plasma Inflammatory Markers and Ventriculostomy-Related Infection in Patients With Hemorrhagic Stroke: A Retrospective and Descriptive Study
ConclusionsNo differences in plasma inflammatory markers could be found between patients with VRI and patients without any infection. Conversely, CRP/PCT were higher in patients with non-cerebral infection than in patients with VRI. Altogether, CRP, PCT, and WBC are not suitable parameters for VRI diagnosis in neurocritical care unit patients.
Source: Frontiers in Neurology - April 25, 2022 Category: Neurology Source Type: research

Spatiotemporal Patterns of Spreading Depolarization and its Correlation with Brain Injury During the Acute Stage of Subarachnoid Hemorrhage in Mice
The objective of this study was to detect real-time spatial-temporal patterns of SD, assess the effect of SD on cerebral blood flow, and test the relationship between SD and brain injury in the acute phase of SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2022 Category: Neurology Authors: Zelong Zheng, Jinbiao Luo, Zhikai Cao, Shaojuan Tan, Jianping Lv Source Type: research

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