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Sirt1 mediates improvement in cognitive defects induced by focal cerebral ischemia following hyperbaric oxygen preconditioning in rats.
Abstract Hyperbaric oxygen preconditioning (HBO-PC) has been proposed as a safe and practical approach for neuroprotection in ischemic stroke. However, it is not known whether HPO-PC can improve cognitive deficits induced by cerebral ischemia, and the mechanistic basis for any beneficial effects remains unclear. We addressed this in the present study using rats subjected to middle cerebral artery occlusion (MCAO) as an ischemic stroke model following HBO-PC. Cognitive function and expression of phosphorylated neurofilament heavy polypeptide (pNF-H) and doublecortin (DCX) in the hippocampus were evaluated 14 days a...
Source: Physiological Research - September 22, 2017 Category: Physiology Authors: Ding P, Ren D, He S, He M, Zhang G, Chen Y, Sang H, Peng Z, Yan W Tags: Physiol Res Source Type: research

Hyperbaric oxygen in patients with ischemic stroke following cardiac surgery: a retrospective observational trial.
CONCLUSIONS: HBO2₂ therapy was associated with significant improvement in patients with acute neurological deficits due to ischemic stroke following cardiac surgery. Though this fact suggests gas embolism as the most likely cause of stroke in this collective, other underlying pathologies cannot be ruled out. Randomized studies are needed for further evaluation. PMID: 29116691 [PubMed - in process]
Source: Undersea and Hyperbaric Medicine - September 1, 2017 Category: Sports Medicine Authors: Weixler VH, Yates AE, Puchinger M, Zirngast B, Pondorfer P, Ratzenhofer-Komenda B, Amegah-Sakotnik A, Smolle-Juettner FM, Dapunt O Tags: Undersea Hyperb Med Source Type: research

Ischaemia-reperfusion injury and hyperbaric oxygen pathways: a review of cellular mechanisms.
Authors: Francis A, Baynosa R Abstract Ischaemia-induced tissue injury has wide-ranging clinical implications including myocardial infarction, stroke, compartment syndrome, ischaemic renal failure and replantation and revascularization. However, the restoration of blood flow produces a 'second hit' phenomenon, the effect of which is greater than the initial ischaemic event and characterizes ischaemia-reperfusion (IR) injury. Some examples of potential settings of IR injury include: following thrombolytic therapy for stroke, invasive cardiovascular procedures, solid organ transplantation, and major trauma resuscitat...
Source: Diving and Hyperbaric Medicine - June 24, 2017 Category: Sports Medicine Tags: Diving Hyperb Med Source Type: research

Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats Basic Sciences
Conclusions—HBO induced activation of ATP/nicotinamide adenine dinucleotide/silent mating type information regulation 2 homolog 1 pathway and protected blood–brain barrier in hyperglycemic middle cerebral artery occlusion rats. HBO might be promising approach for treatment of acute ischemic stroke patients, especially patients with diabetes mellitus or treated with r-tPA (recombinant tissue-type plasminogen activator).
Source: Stroke - May 22, 2017 Category: Neurology Authors: Qin Hu, Anatol Manaenko, Hetao Bian, Zongduo Guo, Jun-Long Huang, Zhen-Ni Guo, Peng Yang, Jiping Tang, John H. Zhang Tags: Animal Models of Human Disease, Basic Science Research, Ischemia, Neuroprotectants Original Contributions Source Type: research

Early Clinical Improvement in Central Retinal Artery Occlusion is Associated with Central Retinal Artery Recanalization (P4.262)
Conclusions:In our case series, no patient without early recanalization of the CRA had ECI. Further studies are merited to determine the impact of CRA recanalization timing and, furthermore, whether fibrinolytic therapy is associated with improved CRA recanalization rates and long-term visual acuity in CRAO patients.Disclosure: Dr. Alkuwaiti has nothing to disclose. Dr. Male has nothing to disclose. Dr. Hendriksen has nothing to disclose. Dr. Engel has nothing to disclose. Dr. Reshi has nothing to disclose. Dr. Ezzeddine has received personal compensation for activities with Air Liquide as a Scientific Advisory Board membe...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Alkuwaiti, M., Male, S., Hendriksen, S., Engel, K., Reshi, R. A., Ezzeddine, M., Emiru, T., Logue, C., Streib, C. Tags: Thrombolysis and Acute Evaluation in Ischemic Stroke Source Type: research

Paradoxical cerebral air embolism causing large vessel occlusion treated with endovascular aspiration
We present a novel therapeutic approach for treatment of cerebral air embolism causing large vessel occlusion, using endovascular aspiration. Our patient developed a cerebral air embolism following sclerotherapy for varicose veins. This caused near total occlusion of the superior division of the M2 segment of the right middle cerebral artery. Symptoms included unilateral paralysis, unintelligible speech, and hemianopia; National Institutes of Health Stroke Scale (NIHSS) on presentation was 16. The air embolism was treated using a distal aspiration technique. Angiography following aspiration showed Thrombolysis in Cerebral ...
Source: Journal of NeuroInterventional Surgery - March 15, 2017 Category: Neurosurgery Authors: Belton, P. J., Nanda, A., Alqadri, S. L., Khakh, G. S., Chandrasekaran, P. N., Newey, C., Humphries, W. E. Tags: Ischemic stroke Source Type: research

Cystatin C Is a Crucial Endogenous Protective Determinant Against Stroke Basic Sciences
Conclusions—CysC is a crucial determinant contributing to endogenous neuroprotection. It is also a novel candidate for stroke treatment through maintaining lysosomal membrane integrity.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Zongping Fang, Jiao Deng, Zhixin Wu, Beibei Dong, Shiquan Wang, Xiaodan Chen, Huang Nie, Hailong Dong, Lize Xiong Tags: Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.
Abstract Sirtuin 1 (Sirt1) is a class III histone deacetylase involved in neuroprotection induced by hyperbaric oxygen preconditioning (HBO-PC) in animal models of ischemia. However, the underlying mechanisms remain to be illustrated. In the present study, rats exposed to middle cerebral artery occlusion (MCAO) were used to establish an ischemic stroke model. The infarct volume ratio, neurobehavioral score, and expressions of Sirt1, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and superoxide dismutase 1 (SOD1) were evaluated at 7days after reperfusion, and the level of malondialdehy...
Source: Behavioural Brain Research - April 26, 2016 Category: Neurology Authors: Xue F, Huang JW, Ding PY, Zang HG, Kou ZJ, Li T, Fan J, Peng ZW, Yan WJ Tags: Behav Brain Res Source Type: research

Hyperbaric oxygen therapy for osteoradionecrosis.
Authors: Cooper PD, Smart DR Abstract Dr Sames and colleagues are to be commended on their thought-provoking article about regional variation in hyperbaric oxygen treatment (HBOT) provision for oro-facial osteoradionecrosis (ORN) across Australia and New Zealand. The four-fold difference between jurisdictions requires further elucidation. As co-directors of the only comprehensive hyperbaric facility in Tasmania, the state with the highest ORN treatment rate, we believe a number of issues pertaining to the Australian situation warrant further consideration. 1. Disease prevalence Comparisons between regions require c...
Source: Diving and Hyperbaric Medicine - April 7, 2016 Category: Sports Medicine Tags: Diving Hyperb Med Source Type: research

The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke
To investigate the mechanistic and functional effects of hyperbaric oxygen therapy (HBOT) in the treatment of ischemic stroke.
Source: Archives of Physical Medicine and Rehabilitation - October 1, 2015 Category: Rehabilitation Authors: Sheila Rosenberg, Stephanie Kaplan, Emily Rosario Tags: Research poster Source Type: research

Can Oxygen Therapy Bring Dead Brain Cells Back To Life?
During my Palm Beach Anti-Aging Summit in October, I’m hosting some of the world’s leading authorities on oxygen therapy. The Summit coincides with the grand opening of my 17,000-sq.-ft. Sears Institute for Anti-Aging Medicine, where I’m unveiling a specially-designed room that houses my first hyperbaric oxygen chamber. I hope you’ll be there, as you’ll discover the newest applications and breakthroughs in this growing field. You see, when oxygen is pressurized — like it is when you’re inside the chamber — you can treat more than just chronic disease. Truth is, hyperbaric oxygen can...
Source: Al Sears, MD Natural Remedies - September 14, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Brain Health brain cells hyperbaric oxygen chamber natural treatment omega-3 fatty acids Palm Beach Anti-Aging Summit Source Type: news

Osteopontin Mediates Hyperbaric Oxygen Preconditioning-Induced Neuroprotection Against Ischemic Stroke
Abstract Neurosurgical operations may result in surgical injury which would lead to postoperative neurological deficits. Hyperbaric oxygen preconditioning (HBO-PC) may be beneficial for such people. However, the exact mechanism underlying HBO-PC is not well known yet. The aim of this study is to explore the role of osteopontin (OPN) in HBO-PC-induced neuroprotection. The study consisted of two experiments. In experiment 1, Sprague Dawley (SD) rats were divided into four groups: sham group, HBO-PC sham group, stroke group, and HBO-PC group (HBO-PC + stroke). The animals in the second experiment were randomly a...
Source: Molecular Neurobiology - July 21, 2015 Category: Neurology Source Type: research

Hyperbaric Oxygen Therapy for Acute Ischemic Stroke Cochrane Corner
Source: Stroke - April 27, 2015 Category: Neurology Authors: Bennett, M. H., Weibel, S., Wasiak, J., Schnabel, A., French, C., Kranke, P. Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Embolic stroke, Emergency treatment of Stroke, Other Stroke Treatment - Medical Cochrane Corner Source Type: research

Hyperbaric Oxygen Preconditioning Attenuates Hemorrhagic Transformation through Increasing PPARγ in Hyperglycemic MCAO Rats.
Abstract Hyperbaric oxygen preconditioning (HBO-PC) has been demonstrated to attenuate hemorrhagic transformation (HT) after middle cerebral artery occlusion (MCAO) in hyperglycemic rats. However, the mechanisms remain to be illustrated. Recently, HBO-PC has been shown to activate peroxisome proliferator-activated receptor-gamma (PPARγ) by increasing 15d-PGJ2 in primary cultured neurons. We hypothesize that HBO-PC reduces HT by suppressing inflammation through increasing 15d-PGJ2 and activating PPARγ in hyperglycemic MCAO rats. HBO (2.5 ATA) was administrated for 1hour daily for 5 consecutive days. The PPARγ in...
Source: Experimental Neurology - December 23, 2014 Category: Neurology Authors: Bian H, Hu Q, Liang X, Chen D, Li B, Tang J, Zhang JH Tags: Exp Neurol Source Type: research

Hyperbaric oxygen therapy for acute ischaemic stroke.
CONCLUSIONS: We found no good evidence to show that HBOT improves clinical outcomes when applied during acute presentation of ischaemic stroke. Although evidence from the 11 RCTs is insufficient to provide clear guidelines for practice, the possibility of clinical benefit has not been excluded. Further research is required to better define the role of HBOT in this condition. PMID: 25387992 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 12, 2014 Category: Journals (General) Authors: Bennett MH, Weibel S, Wasiak J, Schnabel A, French C, Kranke P Tags: Cochrane Database Syst Rev Source Type: research

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