Stroke RSS Page 18

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Specialty: Biochemistry
Condition: Ischemic Stroke

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Total 484 results found since Jan 2013.

Cardiac troponin I measured with a very high sensitivity assay predicts subclinical carotid atherosclerosis: The Akershus Cardiac Examination 1950 Study
CONCLUSION: Concentrations of cTnI measured with a very high sensitivity assay are predictive of carotid atherosclerotic burden, a phenomenon likely attributable to common risk factors of subclinical myocardial injury, coronary and carotid atherosclerosis.PMID:33861986 | DOI:10.1016/j.clinbiochem.2021.04.005
Source: Clinical Biochemistry - April 16, 2021 Category: Biochemistry Authors: Magnus Nakrem Lyngbakken Thea Vigen H åkon Ihle-Hansen Jon Brynildsen Trygve Berge Ole Morten R ønning Arnljot Tveit Helge R øsjø Torbj ørn Omland Source Type: research

Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives
Biochem Biophys Res Commun. 2021 Apr 8;556:99-105. doi: 10.1016/j.bbrc.2021.03.171. Online ahead of print.ABSTRACTTo develop anti-ischemic stroke drugs with higher blood-brain barrier (BBB) penetrating capability and neuroprotective activity, a series of hybrid compounds containing edaravone analogue and 3-n-butylphthalide (NBP) ring-opened derivatives were synthesized and biologically evaluated. Among them, compound 10a displayed the highest protective activity in SH-SY5Y cells against oxygen and glucose deprivation (OGD) and H2O2 insults. Experiment results indicated that 10a could inhibit platelet aggregation via the sy...
Source: Biochemical and Biophysical Research communications - April 11, 2021 Category: Biochemistry Authors: Xuejiao Li Xinxin Wang Longfei Miao Yuying Guo Renbin Yuan Hongqi Tian Source Type: research

Oxytocin improves ischemic stroke by reducing expression of excitatory amino acid transporter 3 in rat MCAO model
This study investigates the neuroprotective effect of OT in an animal model of middle cerebral artery occlusion (MCAO) and the possible role of EAAT3. Transient MCAO was performed as a model of ischemic stroke in male rats and then OT was administrated intra-nasally. Infarct volume was measured by 2, 3, 5-triphenyl tetrazolium chloride staining. Nissl staining method was performed for the evaluation of neuronal cell morphology. Immunohistochemistry assay was performed to analyze the EAAT3 expression in the ischemic region. OT significantly reduced the infarct volume in the cerebral cortex and striatum after ischemia (P<...
Source: Journal of Immunoassay and Immunochemistry - March 31, 2021 Category: Biochemistry Authors: Parinaz Barahimi Mohammad Karimian Majid Nejati Abolfazl Azami Tameh Mohammad Ali Atlasi Source Type: research

Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE)
Amino Acids. 2021 Mar 31. doi: 10.1007/s00726-021-02969-x. Online ahead of print.ABSTRACTTrimethyllysine (TML) is involved in the generation of the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO) by gut microbiota. In clinical studies, elevated TML levels predicted major adverse cardiovascular events (MACE) in patients with acute or stable coronary artery disease (CAD). In contrast to cardiovascular patients, the role of TML in patients with acute cerebral ischemia is unknown. Here, we evaluated circulating TML levels in 374 stroke patients from the prospective biomarkers in stroke (MARK-STROKE) study. Compared wi...
Source: Amino Acids - March 31, 2021 Category: Biochemistry Authors: Edzard Schwedhelm Mirjam von Lucadou Sven Peine Susanne Lezius G ötz Thomalla Rainer B öger Christian Gerloff Chi-Un Choe Source Type: research

Ischemic stroke, obesity, and the anti ‐inflammatory role of melatonin
AbstractObesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it. Pathologies following these conditions are associated with systemic and local inflammation. Moreover, there is increasing evidence that the susceptibility for ischemic brain damage increases substantially in experimental models of ischemic stroke with concomitant obesity. Herein, we explore the proinflammatory events that occur during ischemic stroke and obesity, and we discuss the influence of obesity on the inflammatory response and cerebral damage outcomes in experimental models of brain ischemia. In addition, because melat...
Source: BioFactors - February 10, 2021 Category: Biochemistry Authors: Nuttapong Yawoot, Piyarat Govitrapong, Chainarong Tocharus, Jiraporn Tocharus Tags: REVIEW ARTICLE Source Type: research

TMEM59 protects against cerebral ischemic stroke by suppressing pyroptosis and microglial activation.
In this study, we provided new evidence that TMEM59 expression was significantly down-regulated upon ischemia/reperfusion (I/R). The effect of stroke insult on TMEM59 expression change was only detected in microglial cells by in vitro studies. We observed that TMEM59 knockout markedly accelerated cerebral I/R in mice induced by middle cerebral artery occlusion (MCAO), as evidenced by the elevated infarction volume, neurological deficit scores, brain water contents and neuronal death, further contributing to the abnormal behaviors for mice. We then found that microglial activation reflected by the enhanced expression of Ib...
Source: Biochemical and Biophysical Research communications - January 28, 2021 Category: Biochemistry Authors: Zhang L, Wang T, Chen XF, Xu ZX, Cao JB, Sun H Tags: Biochem Biophys Res Commun Source Type: research

Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis.
Abstract Atherosclerosis results in life-threatening cardiovascular pathologies, including ischemic heart disease, stroke, myocardial infarction, and peripheral arterial disease. The role of increased serum low-density lipoprotein (LDL) and resultant accumulation of oxidized-LDL (oxLDL) in atheroma formation is well established. Recent findings elucidate the significance of mitochondrial damage-associated molecular patterns (mtDAMPs) in triggering sterile inflammation in concert with oxLDL. The mtDAMPs including mitochondrial DNA (mtDNA), cytochrome C, cardiolipin, heat shock protein 60 (HSP60), mitochondrial tran...
Source: Molecular and Cellular Biochemistry - January 25, 2021 Category: Biochemistry Authors: Khwaja B, Thankam FG, Agrawal DK Tags: Mol Cell Biochem Source Type: research

Association of vaspin gene expression and its serum level on the risk of ischemic stroke in type 2 diabetic Egyptian patients: Prospective case ‐control study
In conclusion, the higher levels of serum vaspin and vaspin expression levels in T2DM emphasizes the pivotal role of vaspin serum level and expression in the progression of metabolic and glucose abnormalities, thus, they could be used as biomarkers of IS.
Source: Biotechnology and Applied Biochemistry - January 13, 2021 Category: Biochemistry Authors: Nearmeen M. Rashad, Hanan S. Ahmed, Waleed M. Reda Ashour, Mohammed S. Yousef Tags: Original Article Source Type: research

Uric acid inhibits HMGB1-TLR4-NF- κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia.
Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia. Biochem Biophys Res Commun. 2021 Jan 08;540:22-28 Authors: Wang Q, Zhao H, Gao Y, Lu J, Xie, Yu W, He F, Liu W, Hisatome I, Yamamoto T, Wang W, Cheng J Abstract Mounting evidence has implicated inflammation in ischemia-reperfusion injury following acute ischemic stroke (AIS). Microglia remain the primary initiator and participant of brain inflammation. Emerging evidence has indicated that uric acid has promise for the treatment of AIS, but its explicit mechanisms remain elusive. He...
Source: Biochemical and Biophysical Research communications - January 8, 2021 Category: Biochemistry Authors: Wang Q, Zhao H, Gao Y, Lu J, Xie, Yu W, He F, Liu W, Hisatome I, Yamamoto T, Wang W, Cheng J Tags: Biochem Biophys Res Commun Source Type: research

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