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Specialty: Cancer & Oncology
Condition: Ischemic Stroke
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Total 356 results found since Jan 2013.
Diagnosis and Acute Treatment of Ischemic Stroke
Rev Recent Clin Trials. 2022 Jun 17. doi: 10.2174/1574887117666220617103114. Online ahead of print.ABSTRACTStroke is defined as an acute cerebrovascular accident characterized by an interruption of vascular supply lasting more than 24 hours. Therapeutic goal, reassumed at the well-known "time is brain", is strictly focused on achieving timely restoration of cerebral blood flow at risk of infarction to reduce neurological complications. Consequently, time to treatment is the most important determinant of the efficacy of reperfusion. Current guidelines strongly recommend the use of intravenous thrombolysis with tissue plasmi...
Source: Reviews on Recent Clinical Trials - June 20, 2022 Category: Cancer & Oncology Authors: Ernesto Cristiano Lauritano Federica Nicoletta Sepe Maria Carmela Mascolo Riccardo Boverio Luigi Ruiz Source Type: research
Rare stroke mechanisms in 4154 consecutive patients: causes, predictors, treatment, and outcomes
CONCLUSIONS: RMS occurred in 5.3% of a large population of consecutive AISs and are most frequently related to medical interventions, cancer, and vasculitis. RMS patients have less traditional risk factors but more systemic comorbidities, hemorrhagic transformations, recurrences, and a worse long-term outcome. Identification of RMS has direct implications for early treatment and long-term outcome.PMID:35994133 | DOI:10.1007/s10072-022-06344-w
Source: Cancer Control - August 22, 2022 Category: Cancer & Oncology Authors: Alex Vicino Gaia Sirimarco Ashraf Eskandari Dimitris Lambrou Philippe Maeder Vincent Dunet Patrik Michel Source Type: research
Influenza Vaccination and Risk of Ischemic Stroke: A Population-Based Case-Control Study
DISCUSSION: Results are compatible with a moderate protective effect of influenza vaccine on IS appearing early after vaccination. The finding that a reduced risk was also observed in pre-epidemic periods suggests that either the "protection" is not totally linked to prevention of influenza infection, or it may be partly explained by unmeasured confounding factors.PMID:36240087 | DOI:10.1212/WNL.0000000000201123
Source: Cancer Control - October 14, 2022 Category: Cancer & Oncology Authors: Sara Rodr íguez-Martín Diana Barreira-Hern ández Miguel Gil Alberto Garc ía-Lledó Laura Izquierdo-Esteban Francisco Jose De Abajo Source Type: research
Acute ischaemic stroke and myocardial infarction after chemotherapy with vinorelbine for non-small cell lung cancer: a case report.
We report about a 70-year-old male with metastatic non-small cell lung cancer who received vinorelbine as an outpatient. The patient presents with a cardiovascular risk profile. He was admitted to the hospital 3 days later with acute left-sided hemiplegia and hemianopia. Brain computed tomography (CT) demonstrated acute right hemispheric ischaemic stroke. Nine days after admission, the patient additionally suffered ST elevation myocardial infarction. A coronary angiogram demonstrated high grade stenosis of the right coronary artery treated with two bare-metal stents. Caution should be noted in patients who present with a c...
Source: Journal of Chemotherapy - November 18, 2015 Category: Cancer & Oncology Tags: J Chemother Source Type: research
IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population.
This study is the first to find a correlation between an IMPA2 polymorphism and IS risk in a northwest Han Chinese population. These results may help to elucidate the molecular pathogenesis of this disease, and could potentially be used to predict IS risk. However, further studies are still needed to validate this association in other populations and with larger sample sizes.
PMID: 27661109 [PubMed - as supplied by publisher]
Source: Oncotarget - September 25, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke.
In conclusion, xenogenic ADMSC/ADMSC-derived exosome therapy was safe and offered the additional benefit of reducing BIZ and improving neurological function in rat AIS.
PMID: 27793019 [PubMed - as supplied by publisher]
Source: Oncotarget - October 31, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Predictors of unknown cancer in patients with ischemic stroke
AbstractStroke is the second most frequent neurologic finding in postmortem studies of cancer patients. It has also been described as the first expression of an occult cancer. We have studied patients diagnosed with cancer after an ischemic stroke (IS) and we analyze differences with non-tumor patients. Single cohort longitudinal retrospective study of patients admitted to our center with IS diagnosis from 1 January 2012 to 12 December 2014. All patients were followed for 18 months. Patients with transient ischemic infarction or cerebral hemorrhage, active cancer or in the last 5 years, inability to follow-up or absence...
Source: Journal of Neuro-Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research
Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents
Publication date: Available online 7 January 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Jiabing Wang, Lili Huang, Chanchan Cheng, Ge Li, Jingwen Xie, Mengya Shen, Qian Chen, Wulan Li, Wenfei He, Peihong Qiu, Jianzhang WuAbstractScavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized...
Source: Acta Pharmaceutica Sinica B - January 8, 2019 Category: Cancer & Oncology Source Type: research
Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent
Publication date: Available online 14 August 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Hongxuan Feng, Linghao Hu, Hongwen Zhu, Lingxue Tao, Lei Wu, Qinyuan Zhao, Yemi Gao, Qi Gong, Fei Mao, Xiaokang Li, Hu Zhou, Jian Li, Haiyan ZhangAbstractIschemic stroke is a severe disorder resulting from acute cerebral thrombosis. Here we demonstrated that post-ischemic treatment with ciclopirox olamine (CPX), a potent antifungal clinical drug, alleviated brain infarction, neurological deficits and brain edema in a classic rat model of ischemic stroke. Single dose post-ischemic administration of CPX provided a long-lasting neur...
Source: Acta Pharmaceutica Sinica B - August 15, 2019 Category: Cancer & Oncology Source Type: research
Chronic cerebral hypoperfusion and blood-brain barrier disruption in uninjured brain areas of rhesus monkeys subjected to transient ischemic stroke
J Cereb Blood Flow Metab. 2022 Feb 9:271678X221078065. doi: 10.1177/0271678X221078065. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) disruption is a pivotal pathophysiological process in ischemic stroke. Although temporal changes in BBB permeability during the acute phase have been widely studied, little is known about the chronic phase of cerebrovascular changes that may have a large impact on the long-term outcome. Therefore, this study was aimed to measure cerebral vascular abnormalities using CT perfusion in nine rhesus monkeys subjected to transient middle cerebral artery occlusion (tMCAO) for ≥1 year (MCA...
Source: Cancer Control - February 9, 2022 Category: Cancer & Oncology Authors: Yingqian Zhang Bangcheng Zhao Qi Lai Qinxi Li Xun Tang Yinbing Zhang Zhixiang Pan Qiang Gao Zhihui Zhong Source Type: research
Effectiveness of an individualized home-based physical activity program in surgery-free non-endarterectomized asymptomatic stroke patients: a study protocol for the PACAPh interventional randomized trial
This study has been approved by the National Ethics Committee (IDRCB:2019-A01543-54/SI:19.06.21.40640). ClinicalTrials.gov NCT04053166.PMID:35164816 | DOI:10.1186/s13063-022-06061-x
Source: Cancer Control - February 15, 2022 Category: Cancer & Oncology Authors: Mathilde Mura Emeraude Rivoire Leila Dehina-Khenniche Mich èle Weiss-Gayet B énédicte Chazaud Camille Faes Philippe Connes Anne Long Chantal L Rytz Pauline Mury Lidia Delrieu Etienne Gouraud Marine Bordet Nellie Della Schiava Patrick Lermusiaux Matthie Source Type: research
Atrial Fib, Elevated Lipids Raise Stroke Risk in Cancer Patients Atrial Fib, Elevated Lipids Raise Stroke Risk in Cancer Patients
New-onset or pre-existing AF predicted acute ischemic stroke or TIA in patients with cancer -- as did renal disease, dyslipidemia, and active cancer therapy -- in a case-control study.First Look
Source: Medscape Hematology-Oncology Headlines - February 24, 2022 Category: Cancer & Oncology Tags: Cardiology News Source Type: news
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016
Sci Rep. 2022 Feb 28;12(1):3252. doi: 10.1038/s41598-022-06074-1.ABSTRACTTo determine whether increasing thrombectomy-capable hospitals with moderate comprehensive stroke center (CSC) capabilities is a valid alternative to centralization of those with high CSC capabilities. This retrospective, nationwide, observational study used data from the J-ASPECT database linked to national emergency medical service (EMS) records, captured during 2013-2016. We compared the influence of mechanical thrombectomy (MT) use, the CSC score, and the total EMS response time on the modified Rankin Scale score at discharge among patients with a...
Source: Cancer Control - March 1, 2022 Category: Cancer & Oncology Authors: Ai Kurogi Daisuke Onozuka Akihito Hagihara Kunihiro Nishimura Akiko Kada Manabu Hasegawa Takahiro Higashi Takanari Kitazono Tsuyoshi Ohta Nobuyuki Sakai Hajime Arai Susumu Miyamoto Tetsuya Sakamoto Koji Iihara J-ASPECT Study Collaborators Source Type: research
Drugs Used for Nausea/Vomiting Linked to Stroke Risk Drugs Used for Nausea/Vomiting Linked to Stroke Risk
Antidopaminergic antiemetics (ADAs) used to relieve nausea and vomiting, including that induced by chemotherapy or radiotherapy, have been associated with an increased risk of ischemic stroke.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - March 29, 2022 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
