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Specialty: Hematology
Condition: Ischemic Stroke

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Total 1017 results found since Jan 2013.

Coagulation biomarkers for ischemic stroke
We report on coagulation biomarker-induced risk of IS, stroke severity, and outcomes following IS derived from prospective population studies, case-control studies, and acute-phase IS studies. We found indications that many coagulation and inflammation biomarkers are associated with IS, but it is early to conclude that any of these biomarkers can be applied in a therapeutic setting to predict patients at risk of IS, stroke severity at the acute phase, and clinical outcome after treatment. The strongest evidence for a role in IS was found for beta-thromboglobulin, von Willebrand factor, factor VIII, fibrinogen, thrombin-act...
Source: Thrombosis and Haemostasis - June 5, 2023 Category: Hematology Authors: Aarazo Barakzie A J Gerard Jansen Hugo Ten Cate Moniek P M de Maat Source Type: research

Munc13‐4 mediated secretion is essential for infarct progression but not intracranial haemostasis in acute stroke
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 9, 2013 Category: Hematology Authors: David Stegner, Carsten Deppermann, Peter Kraft, Martina Morowski, Christoph Kleinschnitz, Guido Stoll, Bernhard Nieswandt Tags: Letter ‐ to the Editor Source Type: research

Improving Prediction of Recanalization in Acute Large Vessel Occlusive Stroke.
CONCLUSIONS: Acute endovascular treatment is the single most important factor promoting recanalization in acute ischemic stroke. Presence of extracranial vessel stenosis or occlusion decreases recanalization rates. In patients with intracranial occlusions, higher NIHSS and ASPECTS and normal vigilance facilitate recanalization. Integration in treatment algorithms could influence recanalization strategies in individual patients. This article is protected by copyright. All rights reserved. PMID: 24628853 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 15, 2014 Category: Hematology Authors: Vanacker P, Lambrou D, Eskandari A, Maeder P, Meuli R, Ntaios G, Michel P Tags: J Thromb Haemost Source Type: research

Comparison of costs and discharge outcomes for patients hospitalized for ischemic or hemorrhagic stroke with or without atrial fibrillation in the United States
Abstract This retrospective analysis investigated the impact of baseline clinical characteristics, including atrial fibrillation (AF), on hospital discharge status (to home or continuing care), mortality, length of hospital stay, and treatment costs in patients hospitalized for stroke. The analysis included adult patients hospitalized with a primary diagnosis of ischemic or hemorrhagic stroke between January 2006 and June 2011 from the premier alliance database, a large nationally representative database of inpatient health records. Patients included in the analysis were categorized as with or without AF, based on...
Source: Journal of Thrombosis and Thrombolysis - November 5, 2014 Category: Hematology Source Type: research

Metabolic syndrome, platelet activation and the development of transient ischemic attack or thromboembolic stroke
Stroke is the second most common cause of mortality in the world today, where transient ischemic attack (TIA) is a period of focal ischemia, the symptoms of which resemble a thromboembolic stroke. Contrary to stroke, TIA symptoms typically last less than one hour and necrosis is absent. Stroke is often preceded by TIA, making it an important predictor of future ischemic events. The causal role of atherosclerosis in the development of TIA is well established, however, research indicates that the atherosclerotic process begins years earlier with the development of metabolic syndrome, which affects approximately 45% of the ad...
Source: Thrombosis Research - January 16, 2015 Category: Hematology Authors: Mia-Jeanne van Rooy, Etheresia Pretorius Tags: Review Article Source Type: research

Polymorphisms in prothrombotic genes in young stroke patients in Greece: a case-controlled study
Mechanisms of ischemic stroke in young adults are poorly understood. The aim of the study was to investigate and compare the frequency of common variations in prothrombotic genes between young patients with ischemic stroke and controls. Fifty-one cases of first-ever ischemic stroke and 70 community-based controls aged below 50 years were studied. In both groups, the insertion/deletion 4G/5G variation (−675 4G/5G PAI-1) as well as the single-nucleotide polymorphism-844 G/A of the PAI-1 (−844 G/A PAI-1) gene promoter, factor V Leiden (FVL) G1691Α, the prothrombin variant (allele 20210A, FIIG20210A), factor XIII-A Val34L...
Source: Blood Coagulation and Fibrinolysis - May 1, 2015 Category: Hematology Tags: Original Articles Source Type: research

Usefulness of mean platelet volume for predicting stroke risk in paroxysmal atrial fibrillation patients
Atrial fibrillation is the most common sustained arrhythmia in clinical practice. It is important to specify patients with a high risk of thromboembolus due to elevated procoagulant and prothrombotic state. The aim of this study is to assess the relation of stroke/transient ischaemic attack (TIA) with mean platelet volume (MPV), which is an indicator of platelet activation in patients with paroxysmal atrial fibrillation (PAF). Patients with PAF were enrolled in this study during years of 2012–2014. Patients were divided into two groups according to the presence or absence of stroke/TIA. Demographic data were registered a...
Source: Blood Coagulation and Fibrinolysis - August 5, 2015 Category: Hematology Tags: Original Articles Source Type: research

Severity and outcomes according to stroke etiology in patients under 50 years of age with ischemic stroke
Abstract To analyze the association of stroke etiological subtypes with severity and outcomes at 3 and 12 months in patients ≤50 years. Observational study of patients admitted to a stroke unit (2007–2013). Variables: demographic data, vascular risk factors, comorbidities, severity on admission (NIHSS), and good functional outcome (mRS ≤ 1) at 3 and 12 months. We used multivariate analyses to evaluate the influence of stroke etiology on severity and outcomes. We included 214 patients, 58.3 % men, mean age 41.4 years. General linear models showed all etiologies were more severe than lacunar strokes (P...
Source: Journal of Thrombosis and Thrombolysis - February 5, 2016 Category: Hematology Source Type: research

Platelet function testing in transient ischaemic attack and ischaemic stroke: A comprehensive systematic review of the literature.
Authors: Lim ST, Coughlan CA, Murphy SJ, Fernandez-Cadenas I, Montaner J, Thijs V, Marquardt L, McCabe DJ Abstract The majority of patients with ischaemic cerebrovascular disease (CVD) are not protected from further vascular events with antiplatelet therapy. Measurement of inhibition of platelet function ex vivo on antiplatelet therapy, using laboratory tests that correlate with the clinical effectiveness of these agents, would potentially enable physicians to tailor antiplatelet therapy to suit individuals. A systematic review of the literature was performed to collate all available data on ex vivo platelet functi...
Source: Platelets - February 14, 2016 Category: Hematology Tags: Platelets Source Type: research

Left ventricular geometry and white matter lesions in ischemic stroke patients.
Authors: Butenaerts D, Chrzanowska-Wasko J, Slowik A, Dziedzic T Abstract Abnormal left ventricular (LV) geometry is associated with extracardiac organ damage in patients with hypertension. The aim of this study was to determine the relationship between LV geometry and white matter lesions (WMLs) in ischemic stroke patients. We retrospectively analyzed data from 155 patients (median age 62; 49.8% male) with mild ischemic stroke (median National Institutes of Health Stroke Scale score 4) who underwent brain magnetic resonance imaging and echocardiography. Patients were categorized into four groups: normal LV geometr...
Source: Blood Pressure - February 14, 2016 Category: Hematology Tags: Blood Press Source Type: research

Predictors of Inhospital Mortality in Geriatric Patients Presenting to the Emergency Department With Ischemic Stroke
Conclusion: In evaluating geriatric patients with ischemic stroke, laboratory values including platelet count, creatinine levels, hyperglycemia, and NIHSS scores should be considered to predict inhospital mortality in the ED.
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Dogan, N. O., Akıncı, E., Gümüs, H., Akıllı, N. B., Aksel, G. Tags: Original Articles Source Type: research

Optimising stroke prevention in elderly patients with atrial fibrillation.
This article is protected by copyright. All rights reserved. PMID: 27557552 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 24, 2016 Category: Hematology Authors: Lip GY Tags: J Thromb Haemost Source Type: research

Red Blood Cell Distribution Width Is an Independent Predictor of Outcome in Patients Undergoing Thrombolysis for Ischemic Stroke
Semin Thromb Hemost DOI: 10.1055/s-0036-1592165An appropriate and timely management, including early diagnosis and accurate prognostication, is the mainstay for managed care of patients with acute ischemic stroke. Since red blood cell distribution width (RDW) was found to be an independent predictor of clinical outcomes in patients with thrombotic disorders, we designed a retrospective observational study to investigate whether the RDW value may also retain predictive significance in stoke patients undergoing thrombolytic therapy. This retrospective study was based on all patients admitted to the Emergency Department (ED) ...
Source: Seminars in Thrombosis and Hemostasis - November 2, 2016 Category: Hematology Authors: Turcato, Gianni Cappellari, Manuel Follador, Luca Dilda, Alice Bonora, Antonio Zannoni, Massimo Bovo, Chiara Ricci, Giorgio Bovi, Paolo Lippi, Giuseppe Tags: Review Article Source Type: research

Early function decline after ischemic stroke can be predicted by a nomogram based on age, use of thrombolysis, RDW and NIHSS score at admission
AbstractThe availability of prediction tools for risk stratification after acute stroke is seen as a valuable perspective for tailored clinical management. This retrospective study was aimed to identify significant predictors of poor outcome in patients presenting with acute ischemic stroke, which could then be used for constructing a prediction model. The study population consisted of 837 patients admitted to the Stoke Unit of University Hospital of Verona (Italy) for acute ischemic stroke within 12  h of symptoms onset. In multivariate analysis, age, use of thrombolysis, red blood cell distribution width (RDW) and NIHSS...
Source: Journal of Thrombosis and Thrombolysis - November 11, 2016 Category: Hematology Source Type: research