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Condition: Ischemic Stroke
Therapy: Hormone Replacement Therapy

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Total 24 results found since Jan 2013.

Worsening Severity of Migraines in Current Users of Hormone Replacement Therapy Correlates to Increased Risk of Ischemic Stroke (I2.011)
Conclusions: Current HRT users that have an increase in severity of one grade or more of migraines are shown to have an increased risk of ischemic strokes.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Stroke in the Elderly and Young: Challenges for the Next Decade Poster Presentations Source Type: research

Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria
Free Radic Biol Med. 2022 Mar 24:S0891-5849(22)00123-X. doi: 10.1016/j.freeradbiomed.2022.03.020. Online ahead of print.ABSTRACTIschemic stroke remains a significant unmet need causing massive mortality and morbidity due to few treatment options with limited therapeutic window. The progestin Nestorone® (segesterone acetate) displays high affinity for the progesterone receptor in exerting its potent birth control and hormone replacement therapy. Accumulating evidence implicates a new utility of Nestorone in affording neuroprotection in a variety of central nervous system diseases, including stroke. However, the mechanism o...
Source: Free Radical Biology and Medicine - March 28, 2022 Category: Biology Authors: Jea-Young Lee Vanessa Castelli Narender Kumar Regine Sitruk-Ware Cesario V Borlongan Source Type: research

Previous Use of Unopposed Estrogen Hormone Replacement Therapy Continues to Cause Increased Risk for Future Ischemic Strokes (S4.008)
Conclusions:Previous use of unopposed estrogen HRT continues to increase risk for ischemic stroke after they are discontinued, although combination of estrogen and progesterone HRT do no continue to have a significantly increased risk. Future prospective studies are required to further investigate these correlations.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Health Disparities and Sex Differences in Stroke Source Type: research

Worsening Severity of Migraines in Current Users of Hormone Replacement Therapy Correlates to Increased Risk of Ischemic Stroke (P4.118)
Conclusions: Current HRT users that have an increase in severity of one grade or more of migraines are shown to have an increased risk of ischemic strokes.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Headache: Imaging and Other Source Type: research

A systematic review and meta-regression analysis to examine the ‘timing hypothesis’ of hormone replacement therapy on mortality, coronary heart disease, and stroke
ConclusionYounger initiation of HRT may be effective in reducing death and cardiac events. However, younger HRT initiators remained at an increased risk of stroke, TIA and systemic embolism and this risk increased as average age increased. Younger menopausal women using HRT to treat vasomotor symptoms do not appear to be at an increased risk of dying or experiencing CHD events.
Source: IJC Heart and Vasculature - January 18, 2019 Category: Cardiology Source Type: research

Worsening Migraine During HRT Tied to Increased Stroke Risk Worsening Migraine During HRT Tied to Increased Stroke Risk
Women who have worsening migraines while receiving hormone replacement therapy are at increased risk for ischemic stroke, new research suggests. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - February 18, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Worsening migraines in women using HRT indicate increased risk of stroke
Worsening migraines in users of hormone replacement therapy is associated with an increased risk of ischaemic stroke, according to a new study.
Source: The Pharmaceutical Journal - February 25, 2016 Category: Drugs & Pharmacology Source Type: research

Previous Use of Unopposed Estrogen Hormone Replacement Therapy Continues to Cause Increased Risk for Future Ischemic Strokes (I5.011)
Conclusions:Previous use of unopposed estrogen HRT continues to increase risk for ischemic stroke after they are discontinued, although combination of estrogen and progesterone HRT do no continue to have a significantly increased risk. Future prospective studies are required to further investigate these correlations.Disclosure: Dr. Rahman has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rahman, H., Thomas, A., Malik, A., Saeed, O., Qureshi, A. Tags: Sex-related Factors in Neurological Disease Poster Presentations Source Type: research

Abstract 226: Strokes Worse in Women at 24 hours but Severity Reduced in Younger Women With Hormone Therapy Session Title: Poster Session II
Conclusion: Women in this study had more severe 24 hour AIS outcomes than men but this improved with HRT use in women younger than 80 years. This cannot be fully explained by age differences as there could be other underlying factors. Improving 24 hour NIHSS may correctly predict later outcomes following AIS. Further study of HRT use in AIS outcomes is justified.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Brown, A., Onteddu, S., Joiner, R., Benton, T., Culp, W., Lowery, C. Tags: Session Title: Poster Session II Source Type: research

Transient ischemic attacks in post-menopausal women with history of migraines have lower risk for subsequent ischemic strokes (P2.306)
CONCLUSIONS: The risk of ischemic stroke is lower following TIA in women with migraine history (compared with those without migraine) suggesting potentially different pathophysiology in such women.Disclosure: Dr. Rahman has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Rahman, H., Malik, A., Thomas, A., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Education and TIA Source Type: research

Carotid plaque thickness is positively associated with decreased bone mineral density (P2.264)
CONCLUSIONS: This study showed that increased maximum carotid IMT/plaque value is significantly associated with decreased BMD after controlling for the effects of age, gender, and BMI in acute stroke patients. Study Supported by: NoneDisclosure: Dr. Han has nothing to disclose. Dr. Park has nothing to disclose. Dr. Park has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Han, S. W., Park, J. H., Park, J. H., Lee, J. Y., Lee, K.-Y. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease and IMT Source Type: research

Beyond contraception and hormone replacement therapy: advancing Nestorone to a neuroprotective drug in the clinic.
Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's ability...
Source: Brain Research - October 12, 2018 Category: Neurology Authors: Tuazon JP, Sitruk-Ware R, Borlongan CV Tags: Brain Res Source Type: research

Reprint of: Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic.
Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's ability...
Source: Brain Research - June 14, 2019 Category: Neurology Authors: Tuazon JP, Sitruk-Ware R, Borlongan CV Tags: Brain Res Source Type: research

Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study
ConclusionMultifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI.
Source: BJU International - March 7, 2018 Category: Urology & Nephrology Authors: Alex Tsui, Diana Kuh, Linda Cardozo, Daniel Davis Tags: Original Article Source Type: research