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Optimal medical therapy for coronary artery disease in 2011 - perspectives from the STICH Trial.
Authors: Whayne TF, Saha SP, Quevedo K, Mukherjee D Abstract Medical, percutaneous interventional, and surgical treatments for the management of coronary heart disease have progressed markedly during the past decade. There is evidence to suggest that for patients with stable coronary heart disease optimal medical therapy is equal in effectiveness for lowering the risk of major cardiovascular events, such as cardiovascular death, myocardial infarction, and stroke, as are revascularization procedures, such as coronary artery bypass grafting or percutaneous coronary intervention. The landmark Surgical Treatment for Is...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - November 23, 2014 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Off-hour admission and outcomes for patients with acute myocardial infarction undergoing percutaneous coronary interventions
Conclusions Patients who were admitted during off-hours did not have higher mortality or readmission rates as compared with ones admitted during regular hours at an academic medical center.
Source: American Heart Journal - December 9, 2014 Category: Cardiology Source Type: research

Effect of Prasugrel Pre-Treatment Strategy in Patients Undergoing Percutaneous Coronary Intervention for NSTEMI The ACCOAST-PCI Study
ConclusionsThese findings support deferring treatment with prasugrel until a decision is made about revascularization in patients with NSTEMI undergoing angiography within 48 h of admission. (A Comparison of prasugrel at the time of percutaneous Coronary intervention Or as pre-treatment At the time of diagnosis in patients with non—ST-segment elevation myocardial infarction [ACCOAST]; NCT01015287)
Source: Journal of the American College of Cardiology - December 15, 2014 Category: Cardiology Source Type: research

Sex differences in cardiovascular outcome during progression of aortic valve stenosis
Conclusions In the SEAS study, women and men had similar rates of AS progression and AS-related events. However, women had lower total mortality and ischaemic CV event rate than men independent of confounders. Trial registration number ClinicalTrials.gov identifier: NCT00092677.
Source: Heart - January 14, 2015 Category: Cardiology Authors: Cramariuc, D., Rogge, B. P., Lonnebakken, M. T., Boman, K., Bahlmann, E., Gohlke-Barwolf, C., Chambers, J. B., Pedersen, T. R., Gerdts, E. Tags: Open access, Drugs: cardiovascular system, Echocardiography, Hypertension, Interventional cardiology, Aortic valve disease, Clinical diagnostic tests, Epidemiology Valvular heart disease Source Type: research

Abstract 263: Incidence of Recurrent Cardiovascular Events and Disease Burden Among High-Risk Patients with Hyperlipidemia Session Title: Poster Session II
Conclusions: CV event-related risk and long-term costs are significantly greater among high-risk patients with shorter time intervals between recurrent CV events. Underutilization of LLTs in these patients highlights the need for improving clinical management and treatment options for these patients.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Punekar, R. S., Fox, K. M., Richhariya, A., Fisher, M. D., Gandra, S. R., Cziraky, M. J., Toth, P. P. Tags: Session Title: Poster Session II Source Type: research

Predictive value of the SYNTAX score for short-term cognitive outcomes after off-pump coronary artery bypass surgery
Neuropsychiatric complications of coronary artery bypass grafting (CABG) pose a significant clinical problem that concerns almost one million people undergoing this type of procedure each year worldwide [1]. The severity of these sequelae ranges from minor adverse events (postoperative cognitive decline [POCD], through delirium, depression and psychosis, to major adverse cerebrovascular events (TIA-transient ischemic attack and stroke). There were many efforts to combat this issue, including the development of new surgical techniques (e.g.
Source: International Journal of Cardiology - February 2, 2016 Category: Cardiology Authors: Wojciech Pawliszak, Krzysztof Szwed, Magdalena Szwed, Mariusz Kowalewski, Maciej Bieliński, Małgorzata Piskunowicz, Adam Sukiennik, Katarzyna Zaborowska, Lech Anisimowicz, Alina Borkowska Source Type: research

Simultaneous coronary and carotid revascularisation
Conclusion According to our experiences and results, the simultaneous performance of CEA and CABG in patients with severe coexisting carotid artery disease who require coronary revascularization has proved to be a safe and efficacious operative strategy in these high-risk patients.
Source: Cor et Vasa - February 23, 2016 Category: Cardiology Source Type: research

Valve Replacement for Moderate Aortic Stenosis in Octogenarians Undergoing Revascularization.
CONCLUSION: In-hospital mortality is higher for octogenarians undergoing CABG+AVR compared to those undergoing isolated CABG. In the present study, a 'prophylactic' AVR was justified in patients with moderate AS, and their increased mortality (versus isolated CABG) was congruent with a higher preoperative co-morbid risk profile. Excellent long- term symptom-free survival further justifies 'prophylactic' AVR in octogenarians undergoing CABG with coexistent moderate AS. PMID: 26897807 [PubMed - in process]
Source: Journal of Heart Valve Disease - February 25, 2016 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Impact of preoperative dual antiplatelet therapy on bleeding complications in patients with acute coronary syndromes who undergo urgent coronary artery bypass grafting.
CONCLUSIONS: Preoperative DAPT increases the risk of CABG-related major bleeding in Japanese patients with ACS undergoing urgent CABG. PMID: 26987791 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - March 14, 2016 Category: Cardiology Authors: Nagashima Z, Tsukahara K, Uchida K, Hibi K, Karube N, Ebina T, Imoto K, Kimura K, Umemura S Tags: J Cardiol Source Type: research

Relation between vitamin B12 and SYNTAX Score.
CONCLUSION: In our study, we found significant relationship between vitamin B12 deficiency and SYNTAX score demonstrating the severity and complexity of coronary artery disease. PMID: 27391912 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - July 7, 2016 Category: Cardiology Authors: Cerit L, Duygu H, Gulsen K, Kemal H, Tosun O, Ozcem B, Cerit Z, Gunsel A Tags: Kardiol Pol Source Type: research

Abrogated cardio protective effect of ischemic preconditioning in hyperhomocysteinemia and hypertrophy
Publication date: Available online 1 July 2016 Source:Journal of Indian College of Cardiology Author(s): Shaiba Sana Qureshi, Ahsas Goyal Coronary heart disease has almost affected the mankind throughout history. During the last century, this disorder has emerged as a leading cause of death all over the world. Ischemia contributes in the development of myocardial infarction, stroke, peripheral vascular insufficiency and hypovolemic shock. Reperfusion enhances the tissue injury produced by ischemia alone. Cellular damage after reperfusion of formerly viable ischemic tissues is known as ischemia–reperfusion (I–R) injury...
Source: Journal of Indian College of Cardiology - September 17, 2016 Category: Cardiology Source Type: research

Survival Benefits of Invasive Versus Conservative Strategies in Heart Failure in Patients With Reduced Ejection Fraction and Coronary Artery Disease: A Meta-Analysis Original Articles
Conclusions— The present meta-analysis indicates that revascularization strategies are superior to medical treatment in improving survival in patients with ischemic heart disease and reduced ejection fraction. Between the 2 revascularization strategies, CABG seems more favorable compared with PCI in this particular clinical setting.
Source: Circulation: Heart Failure - January 12, 2017 Category: Cardiology Authors: Wolff, G., Dimitroulis, D., Andreotti, F., Kołodziejczak, M., Jung, C., Scicchitano, P., Devito, F., Zito, A., Occhipinti, M., Castiglioni, B., Calveri, G., Maisano, F., Ciccone, M. M., De Servi, S., Navarese, E. P. Tags: Chronic Ischemic Heart Disease, Heart Failure Original Articles Source Type: research

Cangrelor reduces the risk of ischemic complications in patients with single and multi-vessel disease undergoing PCI: insights from the CHAMPION PHOENIX Trial
Conclusion In the CHAMPION-PHOENIX trial, MVD and SVD patients had similar ischemic outcomes at 48hours and 30days. Cangrelor consistently reduced ischemic complications in both SVD and MVD patients without a significant increase in GUSTO severe bleeding. Clinical Perspectives. What's known? Cangrelor is a novel, intravenous, potent, and rapidly-acting P2Y12 inhibitor, that has been demonstrated to reduce the rate of ischemic events at 48hours in patients who received PCI compared with clopidogrel. What's new? In contrast to prior studies, we found that in this modern cohort, patients with SVD and MVD had a similar risk of...
Source: American Heart Journal - March 9, 2017 Category: Cardiology Source Type: research

Cangrelor reduces the risk of ischemic complications in patients with single-vessel and multi-vessel disease undergoing percutaneous coronary intervention: Insights from the CHAMPION PHOENIX trial
Conclusion In the CHAMPION PHOENIX trial, MVD and SVD patients had similar ischemic outcomes at 48hours and 30days. Cangrelor consistently reduced ischemic complications in both SVD and MVD patients without a significant increase in GUSTO severe bleeding. Clinical perspectives What's known? Cangrelor is a novel, intravenous, potent, and rapidly acting P2Y12 inhibitor that has been demonstrated to reduce the rate of ischemic events at 48hours in patients who received PCI compared with clopidogrel. What's new? In contrast to prior studies, we found that in this modern cohort, patients with SVD and MVD had a similar risk of i...
Source: American Heart Journal - April 18, 2017 Category: Cardiology Source Type: research

The relation between vitamin B12 and SYNTAX score.
CONCLUSIONS: In our study, we found a significant relationship between vitamin B12 deficiency and SYNTAX score, demon-strating the severity and complexity of coronary artery disease. PMID: 27391912 [PubMed - indexed for MEDLINE]
Source: Kardiologia Polska - July 15, 2017 Category: Cardiology Authors: Cerit L, Duygu H, Gulsen K, Kemal H, Tosun O, Ozcem B, Cerit Z, Gunsel A Tags: Kardiol Pol Source Type: research

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