• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3.
In this study, we established a global cerebral ischemia-reperfusion model in mice by bilateral common carotid artery ligation (2VO), and explored the neuroprotective effect of CD21 and its anti-inflammatory mechanism on cerebral ischemia mice. CD21 significantly improved weight loss, neurobehavioral deficits and neurons loss in hippocampal CA1 and caudate putamen (CPu) subregions, which were induced by 2VO in mice. CD21 significantly inhibited the overactivation of astrocyte and microglia, and decreased the mRNA level of IL-6, TNF-α and IL-1β. Moreover, CD21 significantly inhibited the activation of TLR4/NF-κB signalin...
Source: International Immunopharmacology - June 23, 2020 Category: Allergy & Immunology Authors: Li X, Shi MQ, Chen C, Du JR Tags: Int Immunopharmacol Source Type: research

Potential impact of gradual reduction of fat content in manufactured and out-of-home food on obesity in the United Kingdom: a modeling study
CONCLUSIONS: A modest fat reduction (particularly in SFA) in widely consumed foods would prevent obesity, type 2 diabetes, and cardiovascular disease.PMID:33677474 | DOI:10.1093/ajcn/nqaa396
Source: The American Journal of Clinical Nutrition - March 7, 2021 Category: Nutrition Authors: Roberta Alessandrini Feng J He Yuan Ma Vincenzo Scrutinio David S Wald Graham A MacGregor Source Type: research

Melatonin mitigates type 1 diabetes ‐aggravated cerebral ischemia‐reperfusion injury through anti‐inflammatory and anti‐apoptotic effects
ConclusionsT1DM aggravates CIRI. Melatonin treatment is neuroprotective against CIRI in T1DM rats via anti-inflammatory and anti-apoptotic effects.
Source: Brain and Behavior - June 16, 2023 Category: Neurology Authors: Qian Xu, Raymond Tak Fai Cheung Tags: ORIGINAL ARTICLE Source Type: research

Effects of Normobaric Oxygen on the Progression of Focal Cerebral Ischemia in Rats.
Abstract Normobaric oxygen (NBO) reduces infarction at 24-48hrs in experimental models of focal cerebral ischemia. However, to be clinically relevant, longer term safety and efficacy must be explored. Here, we assessed the effects of NBO on glial activation, neurovascular recovery, and behavioral outcomes at 2weeks after transient focal ischemia in rats. 100min transient focal ischemia was induced by intraluminal occlusion of the middle cerebral artery in adult male Sprague-Dawley rats. Animals were randomized into sham, controls or 85'NBO started 15minutes after ischemic onset. Infarct volumes and behavioral outc...
Source: Experimental Neurology - August 16, 2013 Category: Neurology Authors: Esposito E, Mandeville ET, Hayakawa K, Singhal AB, Lo EH Tags: Exp Neurol Source Type: research

Modest weight loss does not decrease cardiovascular morbidity and mortality in adults with type 2 diabetes
Commentary on: Wing RR, Bolin P, Brancati FL, et al.. Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013;369:145–54. Context Diet, physical activity and weight loss are recommended in the management of type 2 diabetes. This recommendation is largely based on short-term intervention studies which show improvements in cardiovascular risk factors including glycaemic control, lipids, blood pressure and inflammation. The Look AHEAD (Action for Health in Diabetes) randomised controlled trial (RCT) studied the impact of long-term weight loss through an...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Davis, N. J., Goswami, G. Tags: Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Drugs: cardiovascular system, Stroke, Hypertension, Diet, Ischaemic heart disease, Diabetes Therapeutics Source Type: research

In women, increased dietary antioxidants are associated with reduced risk of developing heart failure
Commentary on Rautiainen S, Levitan EB, Mittleman MA, et al.. Total antioxidant capacity of diet and risk of heart failure: a population-based prospective cohort of women. Am J Med 2013;126:494–500. Implications for practice and research A diet rich in natural antioxidants may reduce the risk of developing heart failure. Well-designed intervention studies are needed to investigate the effect of a diet rich in antioxidants on heart failure incidence. Context Heart failure is a syndrome comprising symptoms such as breathlessness alongside objective evidence of cardiac dysfunction. This is a common condition with a cons...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Authors: McKeown, P., McKeag, N. Tags: Drugs: cardiovascular system, Heart failure, Stroke, Diet, Vitamins and supplements, Ischaemic heart disease, Diabetes, Medical humanities, Alcohol, Health education, Smoking, Health effects of tobacco use, Tobacco use Women ' s health Source Type: research

Antiphospholipid syndrome: an important differential diagnosis for culture-negative endocarditis
Sometimes the initial diagnosis proves secondary to an illness that is diagnosed later. This was the case when a 37-year-old woman presented to the hospital with sudden-onset persistent left-sided weakness. While she reported pain in the right maxilla, lethargy, and malaise in the month prior to presentation, she denied headache, sensory change, visual disturbances, fever, chills or weight loss. Hypertension was her only cardiovascular risk factor, but she took no regular medications. She had no history of stroke, ischemic heart disease, deep vein thrombosis, pulmonary embolism, or miscarriage, and she had no family histor...
Source: The American Journal of Medicine - November 26, 2014 Category: Journals (General) Authors: Louis W. Wang, Baptiste Noël, Elodie Descloux, David W. Baron Source Type: research

Prognostic value of serum homocysteine levels in elderly hospitalized patients.
CONCLUSION: in elderly patients with multiple comorbidities, both decreased and increased serum homocysteine levels are associated with increased mortality. PMID: 26040370 [PubMed - in process]
Source: Nutricion Hospitalaria - June 6, 2015 Category: Nutrition Authors: Hernández-Betancor I, Martín-Ponce E, Martínez-Riera A, Viña-Rodríguez JJ, González-Reimers E, De la Vega-Prieto MJ, Santolaria F Tags: Nutr Hosp Source Type: research

Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals
Conclusion: Our findings strongly suggest that fitness is associated with a favorable HR profile and is modified by BMI. Intervention programs should place emphasis on fitness and not only on weight loss.Cardiology 2015;132:242-248
Source: Cardiology - September 1, 2015 Category: Cardiology Source Type: research

Pages: 1  2  3  4  5  6