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Potential association between bacterial infections and ischemic stroke based on fifty case-control studies: A systematic review and meta-analysis
CONCLUSIONS: In this meta-analysis, a significant relationship was observed between infection by three bacteria such as C. pneumoniae, H. pylori, and M. tuberculosis with the occurrence of ischemic stroke. Furthermore, due to the similarity between TLRVYK domain in β2-glycoprotein-I and TLRVYK peptide in various of microorganisms, produced antibodies against pathogens interact with β2-glycoprotein-I, hence the cross-reaction phenomenon increases the positive relationship between infectious diseases and ischemic stroke.PMID:35592534 | PMC:PMC9112101 | DOI:10.1016/j.nmni.2022.100980
Source: Atherosclerosis - May 20, 2022 Category: Cardiology Authors: M Keikha M Karbalaei Source Type: research

Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction.
CONCLUSIONS: Our study supports linear correlations between CIMT and IC and hs-CRP levels. However, these associations seem to depend on the type of vascular burden. PMID: 28051279 [PubMed - in process]
Source: Croatian Medical Journal - December 30, 2016 Category: Journals (General) Authors: Kurkowska-Jastrzebska I, Karlinski MA, Błazejewska-Hyzorek B, Sarzynska-Dlugosz I, Filipiak KJ, Czlonkowska A Tags: Croat Med J Source Type: research

Helicobacter pylori infection increases subsequent ischemic stroke risk: a nationwide population-based retrospective cohort study
Conclusion: Chronic HP-I is significantly associated with an increased risk of IS, particularly nonembolic IS. Anti-HP therapy may be beneficial to IS prevention.
Source: QJM - November 24, 2014 Category: Internal Medicine Authors: Huang, W.- S., Tseng, C.- H., Lin, C.- L., Tsai, C.- H., Kao, C.- H. Tags: Original papers Source Type: research

Population attributable burden of Helicobacter pylori -related gastric cancer, coronary heart disease, and ischemic stroke in China
AbstractHelicobacter pylori, a risk factor of cancer and chronic diseases, remains highly prevalent in China. This review aims to systematically evaluate theH. pylori-attributable burden for gastric cancer (GC), coronary heart disease (CHD), and ischemic stroke (IS) in the Chinese population.Helicobacter pylori prevalence was updated by pooling the results reported in studies across China. The population attributable fraction (PAF) was calculated based on theH. pylori prevalence 10  years ago and relative risks of specific disease by reviewing the prospective studies published from 2000 through 2015. In China, the nationw...
Source: European Journal of Clinical Microbiology and Infectious Diseases - January 21, 2017 Category: Microbiology Source Type: research

Combined Effect Of Helicobacter Pylori Infection And Elevated C-Reactive Protein On 3-Month Prognosis Of Ischemic Stroke
Background and Aims: To investigate the combined effect of Helicobacter pylori (HP) infection and elevated C-reactive protein (CRP) on the prognosis of acute ischemic stroke patients at 3 months.
Source: Atherosclerosis - August 2, 2019 Category: Cardiology Authors: T. Xu, C. Zhang, A. Wang, Y. Zhang Tags: E-poster session Source Type: research

Intracranial Large Artery Stenosis and Past Infectious Exposures: Results From the NOMAS Cohort
CONCLUSIONS: Chronic infectious exposures, specifically herpes simplex virus 2 and cytomegalovirus were associated with asymptomatic ILAS as seen on magnetic resonance angiogram imaging. This may represent an additional target of intervention in the ongoing effort to stem the substantial global burden of strokes related to ILAS.PMID:35105181 | DOI:10.1161/STROKEAHA.121.036793
Source: Herpes - February 2, 2022 Category: Infectious Diseases Authors: Amol Mehta Farid Khasiyev Clinton B Wright Tatjana Rundek Ralph L Sacco Mitchell S V Elkind Jose Gutierrez Source Type: research

Stroke Drug Kills Bacteria That Cause Ulcers And Tuberculosis
A drug currently being used to treat ischemic strokes may prove to be a significant advance in the treatment of tuberculosis and ulcers. In a new research report appearing online in The FASEB Journal, a compound called ebselen effectively inhibits the thioredoxin reductase system in a wide variety of bacteria, including Helicobacter pylori which causes gastric ulcers and Mycobacterium tuberculosis which causes tuberculosis. Thioredoxin and thioredoxin reductase proteins are essential for bacteria to make new DNA, and protect them against oxidative stress caused by the immune system...
Source: Health News from Medical News Today - January 2, 2013 Category: Consumer Health News Tags: Tuberculosis Source Type: news

Nonsteroidal Anti-inflammatory Drug and Aspirin-induced Peptic Ulcer Disease.
Abstract Despite decreasing Helicobacter pylori prevalence, the prevalence of peptic ulcer disease is increasing in the aged population, mainly due to increasing use of NSAIDs to manage pain and inflammation. In addition, low dose aspirin is employed as an anti-coagulant for those who have suffered or are at high risk of ischemic stroke and cardiovascular disease. However, NSAIDs and aspirin are injurious to mucosa of stomach and duodenum. NSAID-induced inhibition of mucosal prostaglandin synthesis is thought to be a major mechanism of gastrointestinal mucosal injury. The proportion of elderly has increased rapidl...
Source: Korean J Gastroenter... - June 19, 2016 Category: Gastroenterology Authors: Shim YK, Kim N Tags: Korean J Gastroenterol Source Type: research