Population attributable burden of Helicobacter pylori -related gastric cancer, coronary heart disease, and ischemic stroke in China

AbstractHelicobacter pylori, a risk factor of cancer and chronic diseases, remains highly prevalent in China. This review aims to systematically evaluate theH. pylori-attributable burden for gastric cancer (GC), coronary heart disease (CHD), and ischemic stroke (IS) in the Chinese population.Helicobacter pylori prevalence was updated by pooling the results reported in studies across China. The population attributable fraction (PAF) was calculated based on theH. pylori prevalence 10  years ago and relative risks of specific disease by reviewing the prospective studies published from 2000 through 2015. In China, the nationwide average prevalence ofH. pylori was estimated to be 42.06  % in the general population during 2009–2013. The fixed effects pooled relative risk (RR) of 1.89 [95 % confidence interval (CI): 1.57–2.26] was obtained for gastric cancer andH. pylori infection.Helicobacter pylori infection was responsible for around 37.38  % of noncardia GC, corresponding to about 105,536 cases in 2012. As for extra-gastric disorders,H. pylori infections had higher risk of CHD (RR  = 1.55, 95 % CI: 1.37–1.76) and IS (RR = 1.54, 95 % CI: 1.42–1.66). About 23.15 % of CHD and 22.29 % of IS were attributable toH. pylori infection. The estimates ofH. pylori-attributable burden reveal a great potential of reducingH. pylori-related chronic disease burden byH. pylori eradication. Large prospective studies are warranted to identify whichH. pylori strains, which subt...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research