Stroke RSS Page 4

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Specialty: Neurology
Condition: Ischemic Stroke
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Total 11683 results found since Jan 2013.

The utility of heart-type free fatty-acid binding-protein (HFABP) levels for differentiating acute ischemic stroke from stroke mimics
This study was a prospective, single-center, observational diagnostic accuracy study with a nested cohort design. The estimated sample size was 126 patients, with a 1:1 case and control ratio. We included all consecutive patients with a lateralizing symptom (motor or sensory) or finding suggesting AIS (139 patients) who presented to ED within 24 h of their symptom onset and collected plasma at admission to the ED. After further evaluations, 111 patients (79.8%) were diagnosed with AIS and 28 with other neurological diseases (stroke-mimics).FindingsIn our study, the median HFABP levels of the cases and controls were 2.6 �...
Source: Acta Neurologica Belgica - September 4, 2023 Category: Neurology Source Type: research

Iatrogenic Air Embolisms During Endovascular Interventions: Impact of Origin and Number of Air Bubbles on Cerebral Infarctions
ConclusionIatrogenic AEs originating at the ascending aorta cause a similar number and pattern of cerebral infarctions compared to those with origin at the carotid artery. These findings underline the relevance and potential risk of AE occurring during endovascular interventions at the aortic valve and ascending aorta.
Source: Clinical Neuroradiology - September 4, 2023 Category: Neurology Source Type: research

Predictive value of the Oxford Acute Severity of Illness Score in acute stroke patients with stroke-associated pneumonia
ConclusionOASIS can effectively predict the onset and death of SAP patients and provides a potential reference index for early diagnosis and the prediction of prognosis in patients with SAP. Our findings should be considered in clinical practice.
Source: Frontiers in Neurology - September 4, 2023 Category: Neurology Source Type: research

Frequency and predictors of poststroke epilepsy after mechanical thrombectomy for large vessel occlusion stroke: results from a multicenter cohort study
ConclusionIn our study, patients with large vessel occlusion stroke receiving MT had a 9% prevalence of PSE over a median follow-up period of 6.5 years. Besides larger infarct size, presence of cerebral microbleeds on brain MRI predicted PSE occurrence.
Source: Journal of Neurology - September 2, 2023 Category: Neurology Source Type: research

Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
AbstractFerroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid peroxidation. Animal experiments have shown the important roles of ferroptosis in ischemic stroke, but the evidence in human stroke is insufficient. This prospective study evaluated the associations between plasma ferroptosis biomarkers at hyperacute stage and long-term outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT). The plasma samples were collected immediately before and after EVT (T1 and T2) and at 24 h (T3) for the 126 s...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research

SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
In this study, electrophysiological properties of chloride current in primary cultured neurons were characterized using low chloride solution, 4,4 ′-diisothiocyano-2,2′-stilbenedisulfonic acid, and SLC26A11-specific siRNA under physiological conditions or ATP-depleted conditions. In vivo effect of SLC26A11 was evaluated on a rat stroke reperfusion model. We found that SLC26A11 mRNA in primary cultured neurons was upregulated as early as 6 h after oxygen glucose deprivation, and later, the protein level was elevated accordingly. Blockade of SLC26A11 activity could reduce chloride entry and attenuate hypoxia-induced ne...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research

A modified murine photothrombotic stroke model: a minimally invasive and reproducible cortical and sub-cortical infarct volume and long-term deficits
In conclusion, this modified model helps to understand stroke pathogenesis and minimize the animals' numbers which help to increase the scientific and statistical potential in pre-clinical studies.PMID:37656197 | DOI:10.1007/s00221-023-06696-5
Source: Brain Research - September 1, 2023 Category: Neurology Authors: Mohd Salman Saifudeen Ismael Tauheed Ishrat Source Type: research

Neutrophil-to-lymphocyte ratio at admission is a risk factor for in-hospital gastrointestinal bleeding in acute ischemic stroke patients after dual antiplatelet therapy: A case control study
Gastrointestinal bleeding is a clinically important complication in acute ischemic stroke patients after dual antiplatelet therapy. The present study was to explore the association between neutrophil-to-lymphocyte ratio (NLR) and in-hospital gastrointestinal bleeding in acute ischemic stroke (AIS) patients who had received dual antiplatelet therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2023 Category: Neurology Authors: Jiaming Huang, Foqiang Liao, Yeting Luo, Xu Shu Source Type: research

Oxidative stress and early mortality in acute ischemic stroke: A prospective cohort study
CONCLUSION: MDA serum level was significantly higher in non-survivors than in survivors patients, so MDA could be used as a predictor for early mortality and short-term outcome of cases with AIS.PMID:37652662 | DOI:10.1080/01616412.2023.2252284
Source: Neurological Research - August 31, 2023 Category: Neurology Authors: Eman A Elhamrawy Heba Shoman Hayam Abdel-Tawab Eshak I Bahbah Rasha Sobhy Elattar Naema R Hussein Marwa Sonbol Asmaa AbdElghany Elsheikh Source Type: research

Transradial versus transfemoral access for mechanical thrombectomy in acute ischemic stroke: A retrospective cohort study
The objective of this study was to compare procedural and clinical outcomes in patients with acute ischemic stroke (AIS) treated via transradial access (TRA) mechanical thrombectomy (MT) versus conventional transfemoral access (TFA).
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2023 Category: Neurology Authors: Leonard H. Verhey, Andres Restrepo Orozco, Marion Oliver, Leah Lyons, Andrea P. Sewell, Jenny P-C Tsai, Paul Mazaris, Muhib Khan, Justin A. Singer Source Type: research

Prediction models for post-thrombectomy brain edema in patients with acute ischemic stroke: a systematic review and meta-analysis
ConclusionDespite the promising discriminative ability shown by studies on prediction models for post-thrombectomy brain edema in AIS patients, concerns related to a high risk of bias and limited external validation remain. Future research should prioritize the external validation and optimization of these models. There is an urgent need for large-scale, multicenter studies to develop robust, user-friendly models for real-world clinical application.Systematic review registrationhttps://www.crd.york.ac.uk, unique Identifier: CRD42022382790.
Source: Frontiers in Neurology - August 31, 2023 Category: Neurology Source Type: research

Comparison of three measures for insomnia in ischemic stroke patients: Pittsburgh sleep quality index, insomnia severity index, and Athens insomnia scale
ConclusionEach of the three questionnaires has advantages and disadvantages when assessing insomnia. In the evaluation of insomnia in IS patients, the best questionnaire selection should be made according to the purpose of clinical evaluation and considering the sensitivity and specificity.
Source: Frontiers in Neurology - August 30, 2023 Category: Neurology Source Type: research

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