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Recanalisation therapies for wake-up stroke.
CONCLUSIONS: There is insufficient evidence from randomised controlled trials for recommendations concerning recanalisation therapies for wake-up stroke. Results from ongoing trials will hopefully establish the efficacy and safety of such therapies. PMID: 30129656 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 21, 2018 Category: General Medicine Authors: Roaldsen MB, Lindekleiv H, Mathiesen EB, Berge E Tags: Cochrane Database Syst Rev Source Type: research

Outcomes in Wake-Up Strokes Receiving Intra-Arterial Therapy (P4.294)
Conclusion: Endovascular therapy can improve outcomes in patients with wake-up stroke having a perfusion mismatch. Efforts should be directed towards considering these potential therapeutic interventions for patients who cannot receive IV thrombolysis.Disclosure: Dr. Naragum has nothing to disclose. Dr. Merchant has nothing to disclose. Dr. Shah has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Naragum, V., Merchant, S. H., Shah, Q. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Ischemic Stroke Treatment Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Cerebral Perfusion and the Risk of Dementia in the General Population (I9.006)
Conclusion: Cerebral hypoperfusion is associated with an increased risk of cognitive decline and dementia in the general population. These findings suggest preservation and restoration of cerebral perfusion may limit cognitive decline.Disclosure: Dr. Wolters has nothing to disclose. Dr. Zonneveld has nothing to disclose. Dr. Koudstaal has nothing to disclose. Dr. Hofman has nothing to disclose. Dr. Vernooij has nothing to disclose. Dr. Ikram has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Wolters, F., Zonneveld, H., Koudstaal, P., Hofman, A., Vernooij, M., Ikram, M. Tags: Sleep, Clocks, and Alzheimer ' s Disease Data Blitz Presentations Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

The effects of CPAP-withdrawal on cerebral vascular reactivity and brain oxygenation in patients with obstructive sleep apnoea: a randomised-controlled trial.
Conclusion: Preliminary data analysis suggests an impaired CVR in grey matter in patients with OSA during CPAP-withdrawal. Implications on cardiovascular risk remains to be clarified.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Thiel, S., Lettau, F., Haile, S. R., Rejmer, P., Schwarz, E. I., Stöberl, A., Sievi, N., Rossi, C., Becker, A., Boss, A., Stradling, J. R., Kohler, M. Tags: Sleep and control of breathing Source Type: research

Impact of hypertension on cerebral microvascular structure in CPAP-treated obstructive sleep apnoea patients: a diffusion magnetic resonance imaging study
ConclusionBased on IVIM analysis, cerebral microvascular structure and function showed no difference between hypertensive and normotensive patients with moderate-to-severe OSA treated with CPAP. Treatment adherence with antihypertensive drug regime and, in turn, controlled hypertension seems not to affect microvascular structure and perfusion of the brain.Trial registrationClinicalTrials.gov Identifier: NCT02493673
Source: Neuroradiology - September 15, 2019 Category: Radiology Source Type: research