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Specialty: Molecular Biology
Condition: Epilepsy

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Total 31 results found since Jan 2013.

Mental depression: Relation to different disease status, newer treatments and its association with COVID-19 pandemic (Review)
Mol Med Rep. 2021 Dec;24(6):839. doi: 10.3892/mmr.2021.12479. Epub 2021 Oct 11.ABSTRACTThe present study aimed to review major depression, including its types, epidemiology, association with different diseases status and treatments, as well as its correlation with the current COVID-19 pandemic. Mental depression is a common disorder that affects most individuals at one time or another. During depression, there are changes in mood and behavior, accompanied by feelings of defeat, hopelessness, or even suicidal thoughts. Depression has a direct or indirect relation with a number of other diseases including Alzheimer's disease...
Source: Molecular Medicine Reports - October 11, 2021 Category: Molecular Biology Authors: Mohamed S Abdel-Bakky Elham Amin Tarek M Faris Ahmed A H Abdellatif Source Type: research

A Study to Decipher the Potential Effects of Butylphthalide against Central Nervous System Diseases Based on Network Pharmacology and Molecular Docking Integration Strategy
CONCLUSIONS: Our study proposed a drug-target-disease integrated method to predict the drug repurposing potentials to associated diseases by application of NP and MD, which could be an attractive alternative to facilitate the development of CNS disease therapies. NBP may be promising and showed potentials to be repurposed for treatments for AD, epilepsy, ALS, and depression, and further investigations are warranted to be carefully designed and conducted.PMID:34035826 | PMC:PMC8116153 | DOI:10.1155/2021/6694698
Source: Molecular Medicine - May 26, 2021 Category: Molecular Biology Authors: Qinqin Zhao Bei Zheng Pinpin Feng Xiang Li Source Type: research

The emerging potential of SIRT-3 in oxidative stress-inflammatory axis associated increased neuroinflammatory component for metabolically impaired neural cell.
Abstract People suffering from conditions like epilepsy, where there is an excess of neuron excitement, stroke, and cardiac arrest, where there are oxygen and glucose deprivation, Alzheimer, Parkinson, and Huntington's disease that causes metabolic and also oxidative stress-inflammatory axis; are known to be more vulnerable to disturbances in the metabolism, and there is a lot of inadequacy in defining the inflammation's mechanistic connections, as well as neurodegeneration and the bioenergetic deficiencies in the CNS. We retrieved relevant studies from PubMed/ScienceDirect/Medline/Public library of science/Mendel...
Source: Chemico-Biological Interactions - November 24, 2020 Category: Molecular Biology Authors: Almaliki WH, Alzahrani A, Mahmoud El-Daly ME, Fadel Ahmed AHF Tags: Chem Biol Interact Source Type: research

Expanding and validating the biomarkers for mitochondrial diseases
In this study, we investigated a panel of blood biomarkers in a cohort of 123 mitochondrial patients, with prominent neurological and muscular manifestations. These biomarkers included creatine, fibroblast growth factor 21 (FGF21) and growth/differentiation factor 15 (GDF-15), and the novel cell free circulating-mtDNA (ccf-mtDNA). All biomarkers were significantly increased in the patient group. After stratification by the specific phenotypes, ccf-mtDNA  was significantly increased in the Mitochondrial Encephalomyopathy Lactic Acidosis Stroke-like episodes syndrome (MELAS) group, and FGF21 and GDF-15 were significantly el...
Source: Journal of Molecular Medicine - August 25, 2020 Category: Molecular Biology Source Type: research

Introduction to Purinergic Signaling.
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - October 27, 2019 Category: Molecular Biology Authors: Burnstock G Tags: Methods Mol Biol Source Type: research

mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia.
Authors: Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D Abstract Stroke is considered an underlying etiology of the development of seizures. Stroke leads to glucose and oxygen deficiency in neurons, resulting in brain dysfunction and injury. Mild hypothermia is a therapeutic strategy to inhibit stroke‑induced seizures, which may be associated with the regulation of energy metabolism of the brain. Mammalian target of rapamycin (mTOR) signaling and solute carrier family 2, facilitated glucose transporter member (GLUT)‑1 are critical for energy metabolism. Furthermore, mTOR overactivation and GLUT‑1 deficiency...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Cerebral Cavernous Malformations: An Update on Prevalence, Molecular Genetic Analyses, and Genetic Counselling
Based on the latest gnomAD dataset, the prevalence of symptomatic hereditary cerebral cavernous malformations (CCMs) prone to cause epileptic seizures and stroke-like symptoms was re-evaluated in this review and calculated to be 1:5,400-1:6,200. Furthermore, state-of-the-art molecular genetic analyses of the knownCCM loci are described which reach an almost 100% mutation detection rate for familial CCMs if whole genome sequencing is performed for seemingly mutation-negative families. An update on the spectrum ofCCM1,CCM2, andCCM3mutations demonstrates that deep-intronic mutations and submicroscopic copy-number neutral geno...
Source: Molecular Syndromology - January 24, 2018 Category: Molecular Biology Source Type: research

Potassium channel expression and function in microglia: Plasticity and possible species variations.
Authors: Nguyen HM, Blomster LV, Christophersen P, Wulff H Abstract Potassium channels play important roles in microglia functions and thus constitute potential targets for the treatment of neurodegenerative diseases like Alzheimer's, Parkinson's and stroke. However, uncertainty still prevails as to which potassium channels are expressed and at what levels in different species, how the expression pattern changes upon activation with M1 or M2 polarizing stimuli compared to more complex exposure paradigms, and - most importantly - how these findings relate to the in vivo situation. In this mini-review we discuss the ...
Source: Channels - March 11, 2017 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model
Publication date: Available online 1 November 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Author(s): Samuel Frey, Guillaume Geffroy, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Patrizia Amati-Bonneau, Arnaud Chevrollier, Magalie Barth, Daniel Henrion, Guy Lenaers, Dominique Bonneau, Pascal Reynier, Vincent Procaccio Ketogenic Diet used to treat refractory epilepsy for almost a century may represent a treatment option for mitochondrial disorders for which effective treatments are still lacking. Mitochondrial complex I deficiencies are involved in a broad spectrum of in...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 31, 2016 Category: Molecular Biology Source Type: research

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity
Elevated c-Jun levels result in apoptosis and are evident in neurodegenerative disorders such as Alzheimer's disease and dementia and after global cerebral insults including stroke and epilepsy. NMDA receptor (NMDAR) antagonists block c-Jun upregulation and prevent neuronal cell death following excitotoxic insults. However, the molecular mechanisms regulating c-Jun abundance in neurons are poorly understood. Here, we show that the synaptic component Proline rich 7 (PRR7) accumulates in the nucleus of hippocampal neurons following NMDAR activity. We find that PRR7 inhibits the ubiquitination of c-Jun by E3 ligase SCFFBW7 (F...
Source: EMBO Journal - August 31, 2016 Category: Molecular Biology Authors: Kravchick, D. O., Karpova, A., Hrdinka, M., Lopez-Rojas, J., Iacobas, S., Carbonell, A. U., Iacobas, D. A., Kreutz, M. R., Jordan, B. A. Tags: Neuroscience Articles Source Type: research

Therapeutic Indications and Action Mechanisms of Bilirubin: Suggestions from Natural Calculus Bovis
As a pathological product of bovine gallbladder, natural Calculus Bovis (CB) has a long history in Traditional Chinese Medicine to treat many diseases such as: stroke,coma, delirium, epilepsy, encephalitis B, etc. Experimental studies showed that natural CB had effects on central nervous system, cardiovascular system, inflammation, etc. Recent analyses confirmed that bilirubin composed the main proportion of all CB components. Preclinical researches demonstrated that bilirubin had ischemia protection, antiinflammation, anti-cancer, anti-virus, erythropoiesis, anti-pyretic, immune function protection, and cardiovascular eff...
Source: Current Signal Transduction Therapy - June 21, 2016 Category: Molecular Biology Source Type: research

Fluorescence-Based Automated Screening Assay for the Study of the pH-Sensitive Channel ASIC1a
Acid-sensing ion channel 1a (ASIC1a) is involved in several pathologies, including neurodegenerative and neuroinflammatory disorders, stroke, epilepsy, and inflammatory pain. ASIC1a has been the subject of intense drug discovery programs devoted to the development of new pharmacological tools for its modulation. However, these efforts to generate new compounds have faced the lack of an efficient screening procedure. In the past decades, improvements in screening technologies and fluorescent sensors for the study of ion channels have provided new opportunities in this field. Unfortunately, ASIC1a is mainly a Na+ permeable c...
Source: Journal of Biomolecular Screening - March 18, 2016 Category: Molecular Biology Authors: Mazzocchi, N., De Ceglia, R., Mazza, D., Forti, L., Muzio, L., Menegon, A. Tags: Original Research Source Type: research

Notch receptor expression in human brain arteriovenous malformations
In this study, we performed immunohistochemistry screening on tissue microarrays containing eight surgically resected human brain arteriovenous malformations and 10 control surgical epilepsy samples. The tissue microarrays were evaluated for Notch 1–4 expression. We have found that compared to normal brain vascular tissue Notch‐3 was dramatically increased in brain arteriovenous malformations. Similarly, Notch 4 labelling was also increased in vascular malformations and was confirmed by western blot analysis. Notch 2 was not detectable in any of the human vessels analysed. Using both immunohistochemistry on microarrays...
Source: Journal of Cellular and Molecular Medicine - April 1, 2015 Category: Molecular Biology Authors: Sandra Hill‐Felberg, Hope Hueizhi Wu, Steven A. Toms, Amir R. Dehdashti Tags: Original Article Source Type: research

Acid-sensing ion channels: Trafficking and pathophysiology.
Authors: Zeng WZ, Liu DS, Xu TL Abstract Abstract Acid-sensing ion channels (ASICs) are proton-gated cation channels that are widely expressed in both the peripheral and central nervous systems. ASICs contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke, epileptic seizures and multiple sclerosis. Although much progress has been made in researching the structure-function relationship and pharmacology of ASICs, little is known about the trafficking of ASICs and its contribution to ASIC function. The recent identification of the mechanism of membrane insertion ...
Source: Channels - December 10, 2014 Category: Molecular Biology Tags: Channels (Austin) Source Type: research