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Specialty: Neurology
Condition: Epilepsy
Education: Study

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Total 662 results found since Jan 2013.

Epilepsy Surgery in Adult Stroke Survivors with New-Onset Drug-Resistant Epilepsy
CONCLUSIONS: Patients with stroke-related drug-resistant epilepsy are infrequently considered for epilepsy surgery that could reduce morbidity and mortality.PMID:36373342 | DOI:10.1017/cjn.2022.300
Source: The Canadian Journal of Neurological Sciences - November 14, 2022 Category: Neurology Authors: Tresah C Antaya Britney N Le Lucie Richard Amna Qureshi Salimah Z Shariff Luciano A Sposato Jorge G Burneo Source Type: research

One-year recurrence of stroke and death in Lebanese survivors of first-ever stroke: Time-to-Event analysis
ConclusionHigher rates of stroke recurrence and death were observed in the first year following a stroke in Lebanon. Various factors were identified as significant determinants. Thus, health care providers and officials in Lebanon can use these findings to implement effective preventive strategies to best address the management of these factors to reduce the stroke burden and improve the short and long-term prognosis of stroke survivors.
Source: Frontiers in Neurology - November 14, 2022 Category: Neurology Source Type: research

Monogenic Stroke —Can We Overcome Nature With Nurture?
Although genetic underpinnings of several neurological disorders like epilepsy have been described as early as fourth century bce in the Corpus Hippocraticum, discoveries in stroke have been more recent. One of the first reports demonstrating the importance of heredity in stroke pathogenesis occurred in 1974 with the generation of the stroke-prone spontaneously hypertensive rat. This strain was created using selective breeding and has endured as a valuable asset in contemporary stroke research. Nonetheless, half a century later, the precise genetic determinants even in this single, highly specific rodent stroke phenotype h...
Source: JAMA Neurology - October 27, 2022 Category: Neurology Source Type: research

Low-dose 7,8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy Development
AbstractTemporal lobe epilepsy often manifests months or even years after an initial epileptogenic insult (e.g., stroke, trauma, status epilepticus) and, therefore, may be preventable. However, no such preventive treatment is currently available. Aim of this study was to test an antioxidant agent, 7,8-dihydroxyflavone (7,8-DHF), that is well tolerated and effective in preclinical models of many neurological disorders, as an anti-epileptogenic drug. However, 7,8-DHF also acts as a TrkB receptor agonist and, based on the literature, this effect may imply an anti- or a pro-epileptogenic effect. We found that low- (5  mg/kg),...
Source: Neurotherapeutics - September 30, 2022 Category: Neurology Source Type: research

Acute symptomatic seizures and status epilepticus in older adults: A narrative review focusing on management and outcomes
A clear narrative of acute symptomatic seizures (ASyS) in older adults is lacking. Older adults (≥60 years) have the highest incidence of seizures of all age groups and necessitate a tailored approach. ASyS has a bimodal peak in infancy and old age (82.3–123.2/100,000/year after 65 years of age). ASyS can represent half of the new-onset seizures in older adults and can progress to acute symptomatic status epilepticus (ASySE) in 52–72% of the patients. Common etiologies for ASyS in older adults include acute stroke and metabolic disturbances. For ASySE, common etiologies are acute stroke and anoxic brain injury (ABI)....
Source: Frontiers in Neurology - August 26, 2022 Category: Neurology Source Type: research

Late-onset seizures and epilepsy: Electroclinical features suggestive of autoimmune etiology
ConclusionOur study shows that high-frequency focal seizures with autonomic manifestations should raise the suspicion of AE in the elderly with new-onset seizures. It also highlights the relevant contribution of AEEG, which might reduce the diagnostic delay and provide useful clues to recognize AE.
Source: Frontiers in Neurology - August 12, 2022 Category: Neurology Source Type: research

Efficacy and Safety of the Ketogenic Diet for Mitochondrial Disease With Epilepsy: A Prospective, Open-labeled, Controlled Study
ConclusionThe KD is a safe and effective therapy for seizure control in mitochondrial diseases, especially MELAS and pathogenic variants of mtDNA. KD intervention can be considered in the management of these patients.
Source: Frontiers in Neurology - August 1, 2022 Category: Neurology Source Type: research

Epilepsy in patients with congenital heart disease: A nationwide cohort study
ConclusionsIn this nationwide, register-based cohort study, we found an almost fourfold increased risk of epilepsy in patients with CHD compared to controls; however, the absolute risk was low. Among the identified risk factors, stroke may be potentially preventable.
Source: Brain and Behavior - July 9, 2022 Category: Neurology Authors: Johan Zelano, Mikael Dellborg, Peter Eriksson, Zacharias Mandalenakis Tags: ORIGINAL ARTICLE Source Type: research

Efficacy and safety of antiseizure medication in post-stroke epilepsy
Specific antiseizure medications (ASM) would improve the outcome in post-stroke epilepsy (PSE). The aim of this multicenter observational study was to compare different antiseizure monotherapies in PSE.
Source: Seizure: European Journal of Epilepsy - July 8, 2022 Category: Neurology Authors: Yaroslav Winter, Timo Uphaus, Katharina Sandner, Sven Klimpe, Sebastian von Stuckrad-Barre, Sergiu Groppa Source Type: research

Epilepsy in Cerebrovascular Diseases: A Narrative Review
CONCLUSION: Some aspects of ES and PSE have been well explored, particularly epidemiology and risk factors. On the contrary, few data exist on physiopathology, and existing evidence is mainly based on studies on animal models. Little is also known on seizure semiology, which may also be difficult to interpret by non-epileptologists. Moreover, the therapeutic approach needs standardization as regards indications and the choice of specific ASMs. Future research may help to better elucidate these aspects.PMID:35794769 | DOI:10.2174/1570159X20666220706113925
Source: Epilepsy Curr - July 7, 2022 Category: Neurology Authors: S Neri S Gasparini A Pascarella D Santangelo V Cianci A Mamm ì M Lo Giudice E Ferlazzo U Aguglia Source Type: research

Acute symptomatic seizures and hippocampal sclerosis: the major contributor for post-stroke epilepsy?
AbstractObjectiveHippocampal sclerosis (HS) is a prominent biomarker of epilepsy. If acquired later in life, it usually occurs in the context of degenerative or acute inflammatory-infectious disease. Conversely, acute symptomatic seizures (ASS) are considered a risk factor for developing post-stroke epilepsy, but other factors remain unrecognized. Here, we hypothesize that silent hippocampal injury contributes to the development of post-stroke epilepsy.MethodsWe performed a retrospective observational study of patients hospitalized between 1/2007 and 12/2018 with an acute stroke in the Stroke Center of the Geneva Universit...
Source: Journal of Neurology - July 7, 2022 Category: Neurology Source Type: research