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Condition: Anaphylactic Shock
Drug: Erbitux

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Total 24 results found since Jan 2013.

Perioperative Considerations for the Emerging Alpha-gal Allergy
Alpha-gal syndrome is a constellation of symptoms resultant to an immune-mediated hypersensitivity reaction to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). This type 1 allergic reaction has been diagnosed in an increasing number of patients worldwide, including patients in the United States, Australia, Spain, Sweden, France, and Japan.1,2 It was first identified during clinical trials of the monoclonal antibody, cetuximab, where a disproportionate number of study participants in the southeastern United States experienced anaphylactic reactions compared to other regions of the US (22% vs 1.2%).
Source: Journal of PeriAnesthesia Nursing - August 1, 2021 Category: Nursing Authors: Rachel C. Wolfe, Jeffrey Blunt Tags: Pharmacology Facts Source Type: research

Red Meat Allergies after Lone Star Tick (Amblyomma americanum) Bites.
Authors: Diaz JH Abstract Red meat allergies have followed tick bites on every continent except Antarctica. The sensitizing antigen is galactose-α-1,3-galactose (α-gal), an oligosaccharide constituent of nonprimate blood and meat, acquired by ticks during animal bloodfeeding. Because red meat allergy after tick bites is a worldwide phenomenon, the objectives of this review were to describe the global epidemiology of red meat allergy after tick bites and its immunological mechanisms; to identify the human risk factors for red meat allergy after tick bites; to identify the most common tick vectors of red meat aller...
Source: Southern Medical Journal - June 4, 2020 Category: General Medicine Tags: South Med J Source Type: research

Global Trends in Anaphylaxis Epidemiology and Clinical Implications
Publication date: Available online 28 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Paul J. Turner, Dianne E. Campbell, Megan S. Motosue, Ronna L. CampbellAbstractThe true global scale of anaphylaxis remains elusive, because many episodes occur in the community without presentation to healthcare facilities, and most regions have not yet developed reliable systems with which to monitor severe allergic events. The most robust datasets currently available are based largely on hospital admissions, which are limited by inherent issues of misdiagnosis, misclassification and generaliza...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 29, 2019 Category: Allergy & Immunology Source Type: research

Galactose- α-1,3-galactose (alpha-gal) allergy: first pediatric case in a series of patients in Spain.
CONCLUSIONS: A review is also made of the disorder which, due to its variable clinical expression, is referred to as alpha-gal syndrome. The study concludes that a diagnosis of alpha-gal allergy should be considered in patients with urticaria-anaphylaxis of uncertain origin or manifesting after the administration of vaccines or products of bovine/porcine origin. PMID: 31718865 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - November 8, 2019 Category: Allergy & Immunology Authors: Martín-Lázaro J, Núñez-Orjales R, González-Guzmán LA, González MT, Boquete M, Carballada F Tags: Allergol Immunopathol (Madr) Source Type: research

175 Prevalence and regional differences of sensitization to galactose- α-1,3-galactose and/or cetuximab in Japan
Research has shown that the principal cause of cetuximab-induced anaphylaxis is anti-oligosaccharide IgE antibodies specific for galactose- α-1,3-galactose (α-Gal) present on the mouse-derived Fab portion of the cetuximab heavy chain. Furthermore, it has been revealed that patients who are allergic to cetuximab also develop an allergic reaction to mammalian meat containing the α-Gal owing to cross-reactivity, and the presumed cause o f sensitization is tick bites. The prevalence of red meat allergy is high in Shimane Prefecture located at the western mountainous area of Japan, as is tick-transmitted Japanese spotted fever.
Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: Y. Nakagawa, Y. Chinuki, K. Ueda, O. Tsedendorj, T. Ugajin, H. Yokozeki, E. Morita Tags: Clinical Research and Epidemiology Source Type: research

128 Measurement of galactose-alpha-1,3-galactose-related specific IgE before the first administration of cetuximab can reduce the incidence of cetuximab-induced anaphylactic shock
It is known that the main causative antigenic epitope of cetuximab allergy is galactose-alpha-1,3-galactose (alpha-Gal). In 2013, 13 patients with head and neck cancer received the first administration of cetuximab at Matsue Red Cross Hospital in the western part of Japan, and fourof them developed anaphylactic shock (Incidence rate was 31%). In the sera of these patients, both alpha-Gal specific IgE by CAP-FEIA and cetuximab specific IgE by western blotting were detected. Both sensitivity and specificity in 13 patients of these tests were 100%.
Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: Y. Chinuki, K. Ito, E. Morita Tags: Clinical Research and Epidemiology Source Type: research

The incidence of infusion reactions associated with monoclonal antibody drugs targeting the epidermal growth factor receptor in metastatic colorectal cancer patients: A systematic literature review and meta ‐analysis of patient and study characteristics
ConclusionsIRs occur in approximately 5% of mCRC patients treated with anti ‐EGFR therapies, and the incidence varies significantly by grade of severity and therapy type. Studies evaluating these outcomes should consider investigating survival outcomes by IR status to determine its prognostic relevance.
Source: Cancer Medicine - August 2, 2019 Category: Cancer & Oncology Authors: Lauren C. Bylsma, Rebecca Dean, Kimberly Lowe, Laura Sangar é, Dominik D. Alexander, Jon P. Fryzek Tags: ORIGINAL RESEARCH Source Type: research

Incidence of Hypersensitivity to Cetuximab
Cetuximab is a monoclonal antibody to epidermal growth factor receptor primarily used as adjunctive treatment of metastatic cancers. Hypersensitivity reactions, including anaphylaxis, and especially in the southeastern part of the United States, are one of the most well-known adverse effects of cetuximab. The aim of this meta-analysis is to gain better insight into the overall incidence of cetuximab-induced hypersensitivity reactions.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Saira Q. Zafar, Kirk E. Sperber Source Type: research

249 Different prevalence of sensitization against galactose--1,3-galactose between Shimane and Miyagi in Japan
The red meat allergy caused by tick bites are increasing worldwide. It is known that IgE epitope of major red meat allergens is galactose--1,3-galactose ( α-Gal). Thus, the patients with red meat allergy have a high risk to develop anaphylaxis to taking cetuximab that chimera-type monoclonal antineoplastic drug, because it also contains α-Gal, and its cross-reaction. The α-Gal specific IgE (sIgE) test by CAP-fluoro-enzyme immunoassay (FEIA) is one of the most sensitive examination to identify the patients with red meat allergy.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: O. Tsedendorj, Y. Chinuki, K. Ueda, K. Yamasaki, K. Kikuchi, Y. Ito, S. Aiba, E. Morita Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research

558 Incidence of an anaphylaxis significantly decreased by avoiding cetuximab administration for the subjects sensitized against galactose-alpha-1,3-galactose (alpha-Gal)
Background: A high prevalence of hypersensitivity to cetuximab has been reported in Southeast areas of the United States. IgE antibodies against cetuximab were present in the patients with cetuximab hypersensitivity and the antibodies were specific for galactose-alpha-1,3-galactose (alpha-Gal) in cetuximab heavy-chain. We have also determined that patients with red meat allergy have IgE antibodies against alpha-Gal in Japan. In 2013, 13 patients with SCC of the head and neck were treated with cetuximab in Matsue Red Cross Hospital, and four of the 13 patients (30.8%) had anaphylactic shock during first infusion of cetuximab.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: Y. Chinuki, K. Ito, K. Ueda, E. Morita Tags: Clinical Research: Patient Outcomes Research Source Type: research

249 Different prevalence of sensitization against galactose--1,3-galactose between Shimane and Miyagi in Japan
The red meat allergy caused by tick bites are increasing worldwide. It is known that IgE epitope of major red meat allergens is galactose--1,3-galactose ( α-Gal). Thus, the patients with red meat allergy have a high risk to develop anaphylaxis to taking cetuximab that chimera-type monoclonal antineoplastic drug, because it also contains α-Gal, and its cross-reaction. The α-Gal specific IgE (sIgE) test by CAP-fluoro-enzyme immunoassay (FEIA) is one of the most sensitive examination to identify the patients with red meat allergy.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: O. Tsedendorj, Y. Chinuki, K. Ueda, K. Yamasaki, K. Kikuchi, Y. Ito, S. Aiba, E. Morita Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research

558 Incidence of an anaphylaxis significantly decreased by avoiding cetuximab administration for the subjects sensitized against galactose-alpha-1,3-galactose (alpha-Gal)
Background: A high prevalence of hypersensitivity to cetuximab has been reported in Southeast areas of the United States. IgE antibodies against cetuximab were present in the patients with cetuximab hypersensitivity and the antibodies were specific for galactose-alpha-1,3-galactose (alpha-Gal) in cetuximab heavy-chain. We have also determined that patients with red meat allergy have IgE antibodies against alpha-Gal in Japan. In 2013, 13 patients with SCC of the head and neck were treated with cetuximab in Matsue Red Cross Hospital, and four of the 13 patients (30.8%) had anaphylactic shock during first infusion of cetuximab.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: Y. Chinuki, K. Ito, K. Ueda, E. Morita Tags: Clinical Research: Patient Outcomes Research Source Type: research

Meat allergy associated with galactosyl ‐α‐(1,3)‐galactose (α‐Gal)—Closing diagnostic gaps by anti‐α‐Gal IgE immune profiling
ConclusionsDetection of individual sensitization patterns with different α‐Gal‐containing analytes provides the basis for an individual allergy diagnosis for α‐Gal‐sensitized patients. Higher amounts of α‐Gal in pork and beef innards compared to muscle meat as indicated by a higher staining intensity are a plausible explanation for the difference in allergic symptom severity.
Source: Allergy - August 15, 2017 Category: Allergy & Immunology Authors: U. Jappe, S. Minge, B. Kreft, A. Ludwig, B. Przybilla, A. Walker, R. Varga, P. Seidel, T. Biedermann, W. Anem üller, A. Kromminga, F. Ruëff, H. Merk, N. Wagner, R. Treudler, M. Worm, I. Waldmann, J. Saloga, W. M. Becker, T. Goldmann, T. A. Platts‐Mill Tags: ORIGINAL ARTICLE Source Type: research

Meat allergy associated with α‐Gal – Closing diagnostic gaps by anti‐α‐Gal IgE immune profiling
ConclusionsDetection of individual sensitization patterns with different α‐Gal‐containing analytes provides the basis for an individual allergy diagnosis for α‐Gal sensitized patients. Higher amounts of α‐Gal in pork and beef innards compared to muscle meat as indicated by a higher staining intensity are a plausible explanation for the difference in allergic symptom severity.This article is protected by copyright. All rights reserved.
Source: Allergy - July 3, 2017 Category: Allergy & Immunology Authors: U. Jappe, S. Minge, B. Kreft, A. Ludwig, B. Przybilla, A. Walker, R. Varga, P. Seidel, T. Biedermann, W. Anem üller, A. Kromminga, F. Ruëff, H. Merk, N. Wagner, R. Treudler, M. Worm, I. Waldmann, J. Saloga, W. M. Becker, T. Goldmann, T. A. Platts‐Mill Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Food allergy to the carbohydrate galactose-alpha-1,3-galactose (alpha-gal): four case reports and a review
AbstractUntil recently, food allergies to mammalian meats have been considered to be very rare. The observation that patients not previously exposed to the monoclonal chimeric antibody cetuximab suffered from severe anaphylaxis upon first exposure, led to the identification of galactosealpha- 1,3-galactose as a new relevant carbohydrate allergen. These patients later often suffered from anaphylactic reactions to red meat. Epidemiological data indicated that bites by the tickAmblyomma americanum in the USA, later also byIxodes species in other continents, resulted in sensitisation to alpha-gal. On the other hand, in African...
Source: European Journal of Dermatology - December 31, 2016 Category: Dermatology Source Type: research