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Association Between Ischemic Stroke and Tumor Necrosis Factor Inhibitor Therapy in Patients With Rheumatoid Arthritis
ConclusionExposure to TNFi does not appear to influence the occurrence of ischemic stroke in the medium term in patients with RA. The impact on mortality after ischemic stroke remains inconclusive.
Source: Arthritis and Rheumatism - May 25, 2016 Category: Rheumatology Authors: Audrey S. L. Low, Mark Lunt, Louise K. Mercer, Kath D. Watson, William G. Dixon, Deborah P. M. Symmons, Kimme L. Hyrich Tags: Rheumatoid Arthritis Source Type: research

Artificial intelligence-based preventive, personalized and precision medicine for cardiovascular disease/stroke risk assessment in rheumatoid arthritis patients: a narrative review
AbstractThe challenges associated with diagnosing and treating cardiovascular disease (CVD)/Stroke in Rheumatoid arthritis (RA) arise from the delayed onset of symptoms. Existing clinical risk scores are inadequate in predicting cardiac events, and conventional risk factors alone do not accurately classify many individuals at risk. Several CVD biomarkers consider the multiple pathways involved in the development of atherosclerosis, which is the primary cause of CVD/Stroke in RA. To enhance the accuracy of CVD/Stroke risk assessment in the RA framework, a proposed approach involves combining genomic-based biomarkers (GBBM) ...
Source: Rheumatology International - September 11, 2023 Category: Rheumatology Source Type: research

Occurrence and relative risk of stroke in incident and prevalent contemporary rheumatoid arthritis
Conclusion The magnitude of stroke risk is lower than for ischaemic heart disease in RA, and the evolvement of this risk from RA diagnosis may be slower. This suggests different driving forces behind these two RA co-morbidities and has implications for the clinical follow-up of patients with RA.
Source: Annals of the Rheumatic Diseases - February 25, 2013 Category: Rheumatology Authors: Holmqvist, M., Gransmark, E., Mantel, A., Alfredsson, L., Jacobsson, L. T. H., Wallberg-Jonsson, S., Askling, J. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis patients developing stroke disease: a case-control study using electronic medical record data in northern China
ConclusionsA close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors.
Source: Clinical Rheumatology - February 7, 2019 Category: Rheumatology Source Type: research

Methotrexate might reduce ischemic stroke in patients with rheumatoid arthritis: a population ‐based retrospective cohort study
ConclusionsAt a dosage of > 0.5 defined daily dose, short‐term methotrexate might decrease ischemic stroke risk in RA patients, while hydroxychloroquine and sulfasalazine were neutral.
Source: APLAR Journal of Rheumatology - January 1, 2018 Category: Rheumatology Authors: Hong ‐Wei Tam, Chyong‐Mei Chen, Pui‐Ying Leong, Chao‐Hsi Chen, Yuan‐Chao Li, Yu‐Hsun Wang, Li‐Chi Lin, Jeng‐Yuan Chiou, James Cheng‐Chung Wei Tags: Original Article Source Type: research

Genetic Variants of the NLRP3 Inflammasome Are Associated with Stroke in Patients with Rheumatoid Arthritis.
CONCLUSION: Genetic variants of the NLRP3 inflammasome influence the risk of stroke/TIA, but not of MI/angina pectoris in Swedish patients with established RA. PMID: 26178285 [PubMed - as supplied by publisher]
Source: J Rheumatol - July 15, 2015 Category: Rheumatology Authors: Kastbom A, Ärlestig L, Rantapää-Dahlqvist S Tags: J Rheumatol Source Type: research

Potential benefits of biologics on stroke and mortality in patients with rheumatoid arthritis: A nationwide population ‐based cohort study in Taiwan
ConclusionBiologics used in RA patients have been shown to have a beneficial impact on improving clinical outcomes, including decreased risks of death and stroke. The economic burden from costs of biologics may be alleviated by improving outcomes.
Source: International Journal of Rheumatic Diseases - June 24, 2019 Category: Rheumatology Authors: Chao ‐Hsiun Tang, Fun Yu, Ching‐Ya Huang, Der‐Yuan Chen Tags: ORIGINAL ARTICLE Source Type: research

Rheumatoid Arthritis Patients Have Better Outcomes Than Non-Rheumatoid Arthritis Patients When Hospitalized for Ischemic Stroke: Analysis of the National Inpatient Sample
Objectives The aims of this study were to compare the outcomes of patients primarily admitted for ischemic stroke with and without a secondary diagnosis of RA. Methods Data were abstracted from the National Inpatient Sample (NIS) 2016 and 2017 database. The NIS was searched for hospitalizations for adult patients with ischemic stroke as principal diagnosis with and without RA as secondary diagnosis using International Classification of Diseases, 10th Revision codes. The primary outcome was inpatient mortality. Hospital length of stay (LOS), total hospital charges, odds of receiving tissue plasminogen activator, ...
Source: JCR: Journal of Clinical Rheumatology - December 31, 2021 Category: Rheumatology Tags: Original Articles Source Type: research

Risk of ischemic stroke in patients with polymyositis and dermatomyositis: a systematic review and meta-analysis
Abstract Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been demonstrated to increase ischemic stroke risk, but the data on polymyositis (PM) and dermatomyositis (DM) remain unclear. We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing ischemic risk in patients with PM/DM versus non-PM/DM participants. Pooled risk ratio and 95 % confidence intervals were calculated using a random-effect, generic inverse variance method of DerSimonian a...
Source: Rheumatology International - April 23, 2015 Category: Rheumatology Source Type: research

Genetic liability to rheumatoid arthritis in relation to coronary artery disease and stroke risk
ConclusionThis study found that genetic liability to RA was associated with increased risk of CAD and intracerebral hemorrhage and that the association for CAD might be mediated by CRP. The heightened cardiovascular risk should be actively monitored and managed in RA patients, and this may include damping systemic inflammation.
Source: Arthritis and Rheumatology - May 18, 2022 Category: Rheumatology Authors: Shuai Yuan, Paul Carter, Amy M. Mason, Fangkun Yang, Stephen Burgess, Susanna C. Larsson Tags: Full Length Source Type: research

Association between ischaemic stroke and tumour necrosis factor inhibitor therapy in patients with rheumatoid arthritis
Conclusions: Exposure to TNFi does not appear to influence the occurrence of IS in the medium term in patients with RA. The impact on post‐IS mortality remains inconclusive. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - January 8, 2016 Category: Rheumatology Authors: Audrey S.L. Low, Mark Lunt, Louise K. Mercer, Kath D. Watson, William G. Dixon, Deborah P.M. Symmons, Kimme L. Hyrich Tags: Full Length Source Type: research

Systemic inflammatory response index as an independent risk factor for ischemic stroke in patients with rheumatoid arthritis: a retrospective study based on propensity score matching
ConclusionSIRI was independently associated with the occurrence of ischemic stroke in patients with RA. Thus, RA patients with elevated SIRI should be closely monitored.Key points•RA patients with IS had fewer traditional risk factors such as hypertension and diabetes, while inflammatory indicators were significantly increased.•The SIRI have drawn attention in recent years as novel non-specific inflammatory markers. However, only a few studies have been conducted to investigate their value in RA.•This study completes the gaps in the research on the relationship between SIRI and the risk of IS occurrence in RA patients.
Source: Clinical Rheumatology - May 9, 2021 Category: Rheumatology Source Type: research

Outcomes of hemorrhagic stroke in patients with autoimmune rheumatic diseases: An analysis of the US Nationwide Inpatient Sample
ConclusionsAmong patients admitted to US hospitals for hemorrhagic stroke, patients with RA had decreased risk for in-hospital mortality and prolonged LOS.
Source: International Journal of Rheumatic Diseases - September 20, 2023 Category: Rheumatology Authors: Mao ‐Yu Chen, Pin‐Yuan Chen, Chen‐Nen Chang, Bo‐An Chen, Wen‐Chun Deng, Jiun‐Lin Yan Tags: ORIGINAL ARTICLE Source Type: research

Association of hyperlipidaemia, inflammation and serological status and coronary heart disease among patients with rheumatoid arthritis: data from the National Veterans Health Administration
Conclusions In this predominantly older male RA cohort, there was no clear association between LDL-C and CHD, whereas higher HDL-C was inversely associated with MI and stroke. CRP and ESR were similarly associated with increase MI risk and stroke, reflecting the prominent role of inflammation in CHD risk in RA.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Navarro-Millan, I., Yang, S., DuVall, S. L., Chen, L., Baddley, J., Cannon, G. W., Delzell, E. S., Zhang, J., Safford, M. M., Patkar, N. M., Mikuls, T. R., Singh, J. A., Curtis, J. R. Tags: Open access, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

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