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Condition: Diabetes
Therapy: Dialysis

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Total 274 results found since Jan 2013.

High Thoracic Epidural Analgesia as an Adjunct to General Anesthesia is Associated With Better Outcome in Low-to-Moderate Risk Cardiac Surgery Patients
Conclusion: This large, uniquely matched single-center cohort was generated, and, subject to the listed limitations the authors concluded that supplemental HTEA to general anesthesia had a better outcome in low-risk cardiac surgery patients, with a significantly lower 6-month mortality rate compared with the control group. However, regression analysis revealed that HTEA only had an independently positive effect on the frequency of postoperative dialysis.
Source: Journal of Cardiothoracic and Vascular Anesthesia - July 31, 2013 Category: Anesthesiology Authors: Michael Stenger, Anja Fabrin, Henrik Schmidt, Jacob Greisen, Poul Erik Mortensen, Carl-Johan Jakobsen Tags: Original Article Source Type: research

Decline in renal functioning is associated with longitudinal decline in global cognitive functioning, abstract reasoning and verbal memory
Conclusions Early detection of mild to moderate kidney disease is an important public health concern with regard to cognitive decline.
Source: Nephrology Dialysis Transplantation - July 10, 2013 Category: Transplant Surgery Authors: Davey, A., Elias, M. F., Robbins, M. A., Seliger, S. L., Dore, G. A. Tags: Chronic Kidney Disease Source Type: research

Evaluation of cardiovascular disease burden and therapeutic goal attainment in US adults with chronic kidney disease: an analysis of national health and nutritional examination survey data, 2001--2010
Conclusions: Individuals with CKD have a high prevalence of CV-related comorbidities. However, attainment of LDL-C or BP goals was low regardless of disease stage. These findings highlight the potential for intensive risk factor modification to maximize CV event reduction in CKD patients at high risk for CHD.
Source: BMC Nephrology - June 27, 2013 Category: Urology & Nephrology Authors: Andreas KuznikJack MardekianLisa Tarasenko Source Type: research

If you could propose one idea to help improve health care delivery in the United States, what would it be?
Thumbnail: Tags: conversationsphrma conversationslarry hausnermyrl weinbergchris hansennancy brownContributors: 11621161115911631173Contributions: Read Larry Hausner's bio Despite the rapid development of innovative technologies in the health care field, we have yet to discover a panacea that will easily transform our health care system into one that provides high-quality and cost-effective care.  What we have discovered and come to agree on over the last decade is that our sick care system must be reconfigured to a health care system that emphasizes wellness and prevention.  For that reason, I offer ...
Source: PHRMA - June 24, 2013 Category: Pharmaceuticals Authors: rlowe Source Type: news

Cerebrorenal interaction and stroke.
Abstract Beyond the original meaning of chronic kidney disease (CKD) as high-risk state for future dialysis, CKD is now known as an established risk factor for cardiovascular diseases. Stroke is a major player of cardiovascular disease and has deep two-way relationships with CKD. CKD is an evident risk factor for stroke. Meta-analyses of cohort studies and trials indicate that proteinuria/albuminuria increases the risk of stroke by 71-92%, and reduced glomerular filtration rate increases the risk by 43%. In addition, CKD has a strong relationship with subclinical brain damage including white matter changes, microb...
Source: Contributions to Nephrology - May 26, 2013 Category: Urology & Nephrology Authors: Toyoda K Tags: Contrib Nephrol Source Type: research

Stroke feature and management in dialysis patients.
Abstract Strokes remain the major complication among dialysis population as the number of diabetes and elderly is increasing. In chronic hemodialysis patients, prevalence and incidence of stroke is higher than that of the general population. According to the annual registry data of the Japanese Society for Dialysis Therapy, prevalence of stroke death has been declining, yet the incidence of nonfatal incidence of stroke is not known. Underlying mechanisms of stroke are multiple. Among them, control of hypertension is important for the primary prevention; however, the ideal target level of blood pressure is not dete...
Source: Contributions to Nephrology - May 26, 2013 Category: Urology & Nephrology Authors: Iseki K Tags: Contrib Nephrol Source Type: research

Kidney disease and cognitive function.
Abstract We provide a brief review of research on chronic kidney disease and cognitive performance, including dementia. We touch briefly on the literature relating end-stage-renal disease to cognitive function, but focus on studies of modest and moderate forms of chronic kidney disease (CKD) that precede dialysis and transplantation. We summarize previous reviews dealing with case control studies of patients but more fully examine community-based studies with large samples and necessary controls for demographic risk factors, cardiovascular variables, and other confounds such as depression. In addition we suggest p...
Source: Contributions to Nephrology - May 26, 2013 Category: Urology & Nephrology Authors: Elias MF, Dore GA, Davey A Tags: Contrib Nephrol Source Type: research

Renal physiology and kidney stones
Conclusions: The occurrence of a kidney stone is associated with an increased risk of cardiovascular events including AMI, death due to CHD,PTCA/CABG and stroke. These data suggest that people with a clinically recognized kidney stone should be followed more closely to evaluate for the possibility of subsequent cardiovascular events -- younger people and women.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Alexander, R. T., Samuel, S., Wiebe, N., Bello, A., Klarenbach, S., Curhan, G. C., Tonelli, M., Hemmelgarn, B., Mingione, A., Terranegra, A., Aloia, A., Arcidiacono, T., Brasacchio, C., Hou, J., Dell'Antonio, G., Vezzoli, G., Soldati, L., Shimizu, T., Has Tags: Abstracts Source Type: research

Hypertension - human studies
Conclusions:Higher predialysis SBP variability is associated with stroke on HD populations suggesting a potential role for cerebral perfusion instability. We confirm known associations between age, diabetes, pre-existent cerebrovascular disease and hypertension. In contrast to studies in non-dialysis patients we do not find an association between EPO dose and stroke. Interventional trials of blood pressure management on stroke are recommended.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Power, A., Duncan, N., Pusey, C., Usvyat, L., Marcelli, D., Marelli, C., Kotanko, P., MONDO Consortium, Li, Z., Wang, J., Yuan, X., Wang, J., Wang, L., Ozkayar, N., Altun, B., Yildirim, T., Yilmaz, R., Dede, F., Hayran, M., Arici, M., Aki, T., Erdem, Y., Tags: Abstracts Source Type: research

Open repair of intact thoracoabdominal aortic aneurysms in the American College of Surgeons National Surgical Quality Improvement Program
Objective: Open surgical repair of thoracoabdominal aortic aneurysms (TAAAs) is uncommon. Mortality rates of 20% are reported in studies using national data and are 5% to 8% in single-institution studies. Clinical trials are currently evaluating branched and fenestrated endografts. The purpose of this study is to establish a benchmark for future comparisons with endovascular trials using open repair of TAAAs in the National Surgical Quality Improvement Program (NSQIP) database.Methods: We identified all patients undergoing open elective and emergency surgical repair of intact TAAAs in NSQIP (2005 to 2010) using Current Pro...
Source: Journal of Vascular Surgery - May 6, 2013 Category: Surgery Authors: Rodney P. Bensley, Thomas Curran, Rob Hurks, Ruby C. Lo, Mark C. Wyers, Allen D. Hamdan, Elliot L. Chaikof, Marc L. Schermerhorn Tags: Clinical research studies Source Type: research

Major adverse events, six months after endovascular revascularization for critical limb ischemia in diabetic patients.
CONCLUSION: Based on our findings, it seems that along with current usual therapeutic routines which focus on wound healing and limb salvage, more attention should be paid to simultaneous diagnostic assessments and treatment of cardiovascular disease in this group of patients during short-term follow- up. PMID: 23641737 [PubMed - in process]
Source: Archives of Iranian Medicine - May 1, 2013 Category: Middle East Health Authors: Kassaian SE, Mohajeri-Tehrani MR, Dehghan-Nayyeri A, Saroukhani S, Annabestani Z, Alidoosti M, Shirani S, Shojaei-Fard A, Molavi B, Poorhosseini H, Salarifar M, Aboee-Rad M, Pashang M, Larijani B Tags: Arch Iran Med Source Type: research

Cardiovascular Risk Factors and Events in Pancreas-Kidney Transplants
Abstract: Cardiovascular and cerebrovascular disease (CCVD) are major causes of morbidity and mortality among patients with diabetes. Strict control of treatable risk factors that contribute to atherosclerosis is important to reduce the risk of stroke, myocardial infarction, and peripheral arterial disease. Simultaneous pancreas-kidney transplantation (SPKT) may significantly improve these risk factors in patients with type 1 diabetes. We studied 103 SPKT from our center with both organs functioning for metabolic and hypertensive control; body mass index (BMI); immunosuppression; and CCVD events. The 53 females/50 males s...
Source: Transplantation Proceedings - April 1, 2013 Category: Transplant Surgery Authors: L. Martins, I. Fonseca, L. Dias, J. Malheiro, A. Rocha, P. Azevedo, H. Silva, R. Almeida, A.C. Henriques, J. Davide, A. Cabrita Tags: Renal Transplantation Source Type: research

Fabry nephropathy: indications for screening and guidance for diagnosis and treatment by the European Renal Best Practice
Fabry disease (FD) is an X-linked disorder of glycosphingolipid catabolism resulting in the accumulation of glycolipids including globotriaosylceramide in cells of various tissues resulting in end-organ manifestations. Initially, FD is typically characterized by angiokeratoma and recurrent episodes of neuropathic pain in the extremities occurring during childhood or adolescence. Most affected patients also exhibit a decreased ability to sweat. Later in life, FD results in left ventricular hypertrophy, proteinuria, renal failure and stroke. These later disease manifestations are non-specific and also common in diabetes, hyp...
Source: Nephrology Dialysis Transplantation - March 5, 2013 Category: Urology & Nephrology Authors: Terryn, W., Cochat, P., Froissart, R., Ortiz, A., Pirson, Y., Poppe, B., Serra, A., Van Biesen, W., Vanholder, R., Wanner, C. Tags: NDT PERSPECTIVES Source Type: research

Low serum fetuin A levels and incident stroke in patients with maintenance haemodialysis
ConclusionsFetuin A deficiency is associated with a higher risk of incident stroke among prevalent HD patients.
Source: European Journal of Clinical Investigation - February 19, 2013 Category: Journals (General) Authors: Hung‐Yuan Chen, Yen‐Ling Chiu, Shih‐Ping Hsu, Mei‐Fen Pai, Ju‐Yeh Yang, Yu‐Sen Peng Tags: Original Article Source Type: research

Outcomes of Thrombolytic Treatment for Acute Ischemic Stroke in Dialysis Dependant Patients in the United States (S02.003)
CONCLUSIONS: The three fold higher odds of in-hospital mortality associated with administration of IV thrombolytics in dialysis dependant patients who present with acute ischemic stroke warrants a careful assessment of risk benefit ratio in this population.Disclosure: Dr. Adil has nothing to disclose. Dr. Adil has nothing to disclose. Dr. Irfan has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Tariq, N., Adil, M., Irfan, M., Chaudhry, S., Qureshi, A. Tags: S02 Acute Stroke Therapy Source Type: research