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Condition: Diabetes
Therapy: Statin Therapy

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Total 723 results found since Jan 2013.

Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients with Acute Coronary Syndrome in IMPROVE-IT.
Conclusions -The addition of ezetimibe to simvastatin in patients stabilized after ACS reduces the frequency of ischemic stroke, with a particularly large effect seen in patients with a prior stroke. Clinical Trial Registration -URL: http://www.clinicaltrials.gov Unique Identifier: NCT00202878. PMID: 28972004 [PubMed - as supplied by publisher]
Source: Circulation - September 30, 2017 Category: Cardiology Authors: Bohula EA, Wiviott SD, Giugliano RP, Blazing MA, Park JG, Murphy SA, White JA, Mach F, Van de Werf FJ, Dalby AJ, White HD, Tershakovec AM, Cannon CP, Braunwald E Tags: Circulation Source Type: research

Survivability of patients admitted for stroke in a primary stroke center, Penang, Malaysia: a retrospective 5-year study
CONCLUSION: The findings of the study are intended to encourage more non-stroke hospitals in Malaysia to increase their efforts in treating stroke patients, as early treatment can help reduce the severity of the stroke. With the incorporation of evidence-based data, this study also contributes to local data for comparison and improves the implementation of regularly prescribed stroke medication.PMID:37131240 | DOI:10.1186/s40360-023-00669-8
Source: BMC Pharmacology and Toxicology - May 2, 2023 Category: Drugs & Pharmacology Authors: Monica Danial Nurul Shahira Izwani Mohdradzi Amer Hayat Khan Alan Swee Hock Ch'ng Looi Irene Source Type: research

The effect of statins on National Institutes of Health Stroke Scale (NiHSS) in Ischemic stroke.
Conclusion. According to the findings of this research, taking statins before the onset of stroke and immediately after it showed no significant difference in the level of following dysfunction, measured with NIHSS, and further studies are necessary. PMID: 28316706 [PubMed]
Source: Journal of Medicine and Life - March 23, 2017 Category: Journals (General) Tags: J Med Life Source Type: research

Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study
ConclusionsNight-onset strokes, compared with day-onset strokes, are associated with higher presenting neurologic severity, more frequent END, and worse 3-month functional outcome. These findings suggest that circadian time of onset is an important additional variable for inclusion in epidemiologic natural history studies and in treatment trials of neuroprotective and reperfusion agents for acute ischemic stroke.
Source: PLoS Medicine - February 4, 2022 Category: Internal Medicine Authors: Wi-Sun Ryu Source Type: research

The effect of a locally adapted, secondary stroke risk factor self-management program on medication adherence among veterans with stroke/TIA
Abstract We targeted stroke/transient ischemic attack (TIA) survivors to engage in self-management practices to manage secondary stroke risk factors. We conducted a randomized, regional pilot trial of a locally adapted, secondary stroke prevention program. We implemented the program at two Veterans Administration Medical Centers. Program sessions targeted stroke risk factor self-management. Specifically, we evaluated the effect of the program on the reach, implementation, and effectiveness on patient self-efficacy; stroke-specific, health-related quality of life; and medication adherence for the prevalent stroke r...
Source: Translational Behavioral Medicine - October 26, 2015 Category: Global & Universal Source Type: research

Reduction in Early Stroke Risk in Carotid Stenosis With Transient Ischemic Attack Associated With Statin Treatment
In patients with acute symptomatic carotid stenosis, statin pretreatment is associated with reduced stroke risk. Carotid endarterectomy (CEA) in patients with associated symptoms is highly effective for secondary stroke prevention. Maximum benefit appears to be in those who undergo surgery ≤2 weeks of symptom onset; however, the safety of very early CEA has been questioned. Data from the Swedish Vascular Registry indicated an 11.5% stroke and death rate in patients undergoing CEA ≤48 hours of symptom onset. This is a fourfold increase in the odds of a poor outcome compared with those undergoing CEA from 3 to 7 days (S...
Source: Journal of Vascular Surgery - January 24, 2014 Category: Surgery Authors: Á. Merwick, G.W. Albers, E.M. Arsava Tags: Abstracts Source Type: research

Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study
ConclusionsThese findings suggest that patients (both men and women) with atherothrombotic infarction who have low TC levels would not benefit from receiving statin treatment. Therefore, it is crucial to explore the impact of statin treatment on outcomes in Asian patients, especially Chinese patients with atherothrombotic and low TC levels, in order to improve outcomes after stroke and reduce the disease burden.
Source: Biology of Sex Differences - November 23, 2016 Category: Biology Source Type: research

Transient ischemic attack and ischemic stroke patients with or without prior stroke
ConclusionsBoth in TIA and IS, vascular risk factors were more common in patients with a history of stroke compared with those without. In contrast to other secondary preventive medications, OAC treatment in the presence of AF was underutilized in patients with a history of stroke.
Source: Acta Neurologica Scandinavica - June 1, 2017 Category: Neurology Authors: F. Buchwald, B. Norrving, J. Petersson Tags: ORIGINAL ARTICLE Source Type: research

Suboptimal lipid management before and after ischaemic stroke and TIA —the North Dublin Population Stroke Study
ConclusionsIn this population-based study, LLT recommended by international guidelines was under-used, before and after index stroke/TIA. Strategies to improve adherence are needed.
Source: Irish Journal of Medical Science - January 24, 2018 Category: General Medicine Source Type: research