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Condition: Diabetes
Drug: Lithium

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Total 64 results found since Jan 2013.

Accelerated-Onset Diabetes Insipidus Secondary to Lithium Use
Prim Care Companion CNS Disord. 2023 Jun 22;25(3):22cr03427. doi: 10.4088/PCC.22cr03427.NO ABSTRACTPMID:37347676 | DOI:10.4088/PCC.22cr03427
Source: Primary Care - June 22, 2023 Category: Primary Care Authors: Deepti Divya Gopisetty Matthew Gunther Shixie Jiang Source Type: research

Metabolic reprogramming of renal epithelial cells contributes to lithium-induced nephrogenic diabetes insipidus
Biochim Biophys Acta Mol Basis Dis. 2023 May 26:166765. doi: 10.1016/j.bbadis.2023.166765. Online ahead of print.ABSTRACTLithium, mainstay treatment for bipolar disorder, frequently causes nephrogenic diabetes insipidus (NDI) and renal injury. However, the detailed mechanism remains unclear. Here we used the analysis of metabolomics and transcriptomics and metabolic intervention in a lithium-induced NDI model. Mice were treated with lithium chloride (40 mmol/kg chow) and rotenone (ROT, 100 ppm) in diet for 28 days. Transmission electron microscopy showed extensive mitochondrial structural abnormalities in whole nephron. RO...
Source: Biochimica et Biophysica Acta - May 28, 2023 Category: Biochemistry Authors: Mi Liu Mokan Deng Qimei Luo Peng Sun Ailin Liang Xiulin Li Xiaojie Luo Jianyi Pan Wei Zhang Min Mo Xiangdong Guo Xianrui Dou Zhanjun Jia Source Type: research

Lithium treatment mitigates the diabetogenic effects of chronic cortico-therapy
CONCLUSION AND IMPLICATIONS: Collectively, our data provide evidences for the beneficial effects of lithium to mitigate the adverse metabolic effects of chronic cortico-therapy.PMID:37224758 | DOI:10.1016/j.biopha.2023.114895
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2023 Category: Drugs & Pharmacology Authors: Etienne Delangre Ga ëlle Pommier Stefania Tolu Benjamin Uzan Danielle Bailb é Jamileh Movassat Source Type: research

"Aquaporin-omics": Mechanisms of Aquaporin-2 Loss in Polyuric Disorders
This article is protected by copyright. All rights reserved.PMID:37114282 | DOI:10.1113/JP284634
Source: The Journal of Physiology - April 28, 2023 Category: Physiology Authors: Angela Mak Chih-Chien Sung Trairak Pisitkun Sookkasem Khositseth Mark A Knepper Source Type: research

Iatrogenic endocrine complications of lithium therapy
Ann Endocrinol (Paris). 2023 Mar 22:S0003-4266(23)00045-8. doi: 10.1016/j.ando.2023.03.004. Online ahead of print.ABSTRACTLithium is a cation, similar to sodium and potassium, affecting ion transport. It is used in the medical field as a treatment of bipolar disorders. The main endocrine complications of lithium treatment affect thyroid and parathyroid glands, in association with renal complications. Thyroid adverse effects, which are more frequent in women, comprise hypothyroidism, goiter, or sometimes hyperthyroidism, through interference with the iodine symporter. The increase in thyroid volume is early. Prevalence of g...
Source: Annales d'Endocrinologie - March 24, 2023 Category: Endocrinology Authors: M C Vantyghem Source Type: research

Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Diagnostic trap: Lithium neurotoxicity with normal lithemia
We describe here the case of a 54-year-old bipolar woman, followed in psychiatry and treated with lithium and a selective serotonin reuptake inhibitor (escitalopram) and lamotrigine, presenting a lithium poisoning with an altered state of consciousness caused by a supposed mismanagement of her treatment. Lithium poisoning was suggested based on neurological clinical features, but the blood test brought out a lithium concentration within the therapeutic values at 1,2 mmol/L (N: 0,6-1,2 mmol/L). The classic biological complications related to lithium poisoning (hypercalcemia, diabetes insipidus) confirmed the diagnosis. The ...
Source: Nephrologie and Therapeutique - September 26, 2022 Category: Urology & Nephrology Authors: Hugo Tiv Antoine Vandelaer Pierre Delanaye Florence Forte Antoine Bouquegneau Source Type: research

Psychotropic Drugs and Adverse Kidney Effects: A Systematic Review of the Past Decade of Research
ConclusionsDespite the heterogeneity of findings, owing to varying methodologies and research challenges, recent studies strongly suggest that lithium is associated with an increased risk of chronic kidney disease and nephrogenic diabetes insipidus, especially in older adults and long-term lithium users. Clinicians should balance the harms of lithium against its established benefits, and ensure adequate monitoring and management of comorbidities in all patients. Weaker evidence suggests that antiepileptics such as valproate and antipsychotics result in comparatively less harm to the kidney than lithium, but warrant monitor...
Source: CNS Drugs - September 26, 2022 Category: Neurology Source Type: research

Diabetes és a nyomelemek
Orv Hetil. 2022 Aug 14;163(33):1303-1310. doi: 10.1556/650.2022.32550. Print 2022 Aug 14.ABSTRACTIonic or complex compounds of certain trace elements are essential for the proper functioning of the human body in numerous biochemical processes. Their absence or accumulation causes many health problems and diseases. In the past, trace elements have been thought to be a key factor in the treatment of insulin resistance and diabetes, however, the importance and lack of trace elements in the development of diabetes or the assessment of trace element status in the development and treatment of complications are still controversia...
Source: Orvosi Hetilap - August 14, 2022 Category: General Medicine Authors: Kl ára Szentmihályi Szilvia Kl ébert Anik ó Somogyi Source Type: research