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Condition: Diabetes
Countries: Japan Health
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Total 1590 results found since Jan 2013.
Tirzepatide immunogenicity on pharmacokinetics, efficacy, and safety: analysis of data from Phase 3 studies
CONCLUSIONS: Immunogenicity did not impact tirzepatide pharmacokinetics or efficacy. Majority hypersensitivity or injection site reactions experienced by TE ADA+ patients were mild to moderate in severity.PMID:37700637 | DOI:10.1210/clinem/dgad532
Source: The Journal of Clinical Endocrinology and Metabolism - September 13, 2023 Category: Endocrinology Authors: Garrett Mullins Michael E Hodsdon Ying Grace Li Greg Anglin Shweta Urva Karen Schneck Jennifer N Bardos Ricardo Fonseca Martins Katelyn Brown Boris Calderon Source Type: research
Her work paved the way for blockbuster obesity drugs. Now, she ’s fighting for recognition
When Svetlana Mojsov heard the spring 2021 announcement, she was startled. The Canada Gairdner International Award, a prestigious biomedical research prize, would be bestowed on three scientists for work underpinning the diabetes and obesity drugs that have exploded in popularity in recent years. “I was really upset,” recalls Mojsov, a chemist at Rockefeller University.
The Gairdner award marked the third time in 4 years that the same trio of scientists—Joel Habener at Massachusetts General Hospital (MGH), Daniel Drucker at the University of Toronto, and Jens Juul Holst at the University of Copenhagen—were hon...
Source: Science of Aging Knowledge Environment - September 8, 2023 Category: Geriatrics Source Type: research
Utility of growth differentiation factor-15 as a predictor of cardiovascular surgery outcomes: Current research and future directions
This study acknowledges that the relationship between patient outcomes and elevated GDF-15 levels is not limited to CVDs or cardiac surgery but can be associated with variable diseases, including diabetes and cancer. Moreover, the normal range of GDF-15 is not well defined. Given its promise for improving patient care and outcomes in cardiovascular surgery, future research should explore the potential of GDF-15 as a biomarker for postoperative outcomes and target therapeutic intervention.PMID:37648079 | DOI:10.1016/j.jjcc.2023.08.013
Source: Journal of Cardiology - August 30, 2023 Category: Cardiology Authors: Ikuko Shibasaki Naoyuki Otani Motoshi Ouchi Taira Fukuda Taiki Matsuoka Shotaro Hirota Shohei Yokoyama Yuta Kanazawa Takashi Kato Riha Shimizu Masahiro Tezuka Yusuke Takei Go Tsuchiya Shunsuke Saito Taisuke Konishi Koji Ogata Shigeru Toyoda Hirotsugu Fuku Source Type: research
Association between sodium-glucose cotransporter 2 inhibitors and pancreatic cancer in the Japanese working-age population
CONCLUSION: SGLT2 inhibitors may reduce the risk of developing pancreatic cancer in T2DM patients. The number of patients over 65 years of age was small in this study due to the nature of the data source. Further studies with larger sample sizes including older patients are needed.PMID:37644877 | DOI:10.5414/CP204465
Source: Clinical Pharmacology and Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Yuki Tanaka Satoshi Yokoyama Chihiro Nakagawa Takaya Uno Kouichi Hosomi Source Type: research
Utility of growth differentiation factor-15 as a predictor of cardiovascular surgery outcomes: Current research and future directions
This study acknowledges that the relationship between patient outcomes and elevated GDF-15 levels is not limited to CVDs or cardiac surgery but can be associated with variable diseases, including diabetes and cancer. Moreover, the normal range of GDF-15 is not well defined. Given its promise for improving patient care and outcomes in cardiovascular surgery, future research should explore the potential of GDF-15 as a biomarker for postoperative outcomes and target therapeutic intervention.PMID:37648079 | DOI:10.1016/j.jjcc.2023.08.013
Source: Journal of Cardiology - August 30, 2023 Category: Cardiology Authors: Ikuko Shibasaki Naoyuki Otani Motoshi Ouchi Taira Fukuda Taiki Matsuoka Shotaro Hirota Shohei Yokoyama Yuta Kanazawa Takashi Kato Riha Shimizu Masahiro Tezuka Yusuke Takei Go Tsuchiya Shunsuke Saito Taisuke Konishi Koji Ogata Shigeru Toyoda Hirotsugu Fuku Source Type: research
Association between sodium-glucose cotransporter 2 inhibitors and pancreatic cancer in the Japanese working-age population
CONCLUSION: SGLT2 inhibitors may reduce the risk of developing pancreatic cancer in T2DM patients. The number of patients over 65 years of age was small in this study due to the nature of the data source. Further studies with larger sample sizes including older patients are needed.PMID:37644877 | DOI:10.5414/CP204465
Source: Clinical Pharmacology and Therapeutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Yuki Tanaka Satoshi Yokoyama Chihiro Nakagawa Takaya Uno Kouichi Hosomi Source Type: research
Utility of growth differentiation factor-15 as a predictor of cardiovascular surgery outcomes: Current research and future directions
This study acknowledges that the relationship between patient outcomes and elevated GDF-15 levels is not limited to CVDs or cardiac surgery but can be associated with variable diseases, including diabetes and cancer. Moreover, the normal range of GDF-15 is not well defined. Given its promise for improving patient care and outcomes in cardiovascular surgery, future research should explore the potential of GDF-15 as a biomarker for postoperative outcomes and target therapeutic intervention.PMID:37648079 | DOI:10.1016/j.jjcc.2023.08.013
Source: Journal of Cardiology - August 30, 2023 Category: Cardiology Authors: Ikuko Shibasaki Naoyuki Otani Motoshi Ouchi Taira Fukuda Taiki Matsuoka Shotaro Hirota Shohei Yokoyama Yuta Kanazawa Takashi Kato Riha Shimizu Masahiro Tezuka Yusuke Takei Go Tsuchiya Shunsuke Saito Taisuke Konishi Koji Ogata Shigeru Toyoda Hirotsugu Fuku Source Type: research
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Relationship between the cholesterol and triglyceride content of lipoprotein subclasses and carotid intima-media thickness: a cross-sectional population-based study
CONCLUSIONS: Smaller LDL particle cholesterol values are the most atherogenic lipoprotein parameter.PMID:37597644 | DOI:10.1016/j.cca.2023.117521
Source: Atherosclerosis - August 19, 2023 Category: Cardiology Authors: Hiroaki Ikezaki Norihiro Furusyo Masumi Ai Mitsuyo Okazaki Takuji Kohzuma Jun Hayashi Nobuyuki Shimono Ernst J Schaefer Source Type: research
Renal pathology in adult and paediatric population of Japan: review of the Japan renal biopsy registry database from 2007 to 2017
CONCLUSIONS: This study describes the distribution and changes in kidney biopsy diagnoses over 10 years in Japan and paves the way for future research on kidney diseases in adults and children.PMID:37597092 | DOI:10.1007/s40620-023-01687-9
Source: Journal of Nephrology - August 19, 2023 Category: Urology & Nephrology Authors: Kazunori Goto Takahiro Imaizumi Riku Hamada Kenji Ishikura Tomoki Kosugi Ichiei Narita Hitoshi Sugiyama Akira Shimizu Hitoshi Yokoyama Hiroshi Sato Shoichi Mauryama Source Type: research
Relationship between the cholesterol and triglyceride content of lipoprotein subclasses and carotid intima-media thickness: a cross-sectional population-based study
CONCLUSIONS: Smaller LDL particle cholesterol values are the most atherogenic lipoprotein parameter.PMID:37597644 | DOI:10.1016/j.cca.2023.117521
Source: International Journal of Clinical Chemistry - August 19, 2023 Category: Chemistry Authors: Hiroaki Ikezaki Norihiro Furusyo Masumi Ai Mitsuyo Okazaki Takuji Kohzuma Jun Hayashi Nobuyuki Shimono Ernst J Schaefer Source Type: research
