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Condition: Psoriasis

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Total 185 results found since Jan 2013.

Association of psoriasis and stroke in end-stage renal disease patients
CONCLUSIONS: Contrary to prior research in the general population, psoriasis in ESRD patients was not associated with the risk of stroke after controlling for various demographic and clinical parameters. Our finding emphasizes the importance of controlling for a variety of factors in population studies examining associations of diseases and risk factors.PMID:37716600 | DOI:10.1016/j.amjms.2023.09.014
Source: The American Journal of the Medical Sciences - September 16, 2023 Category: General Medicine Authors: Naomi Siddiquee Jennifer L Waller Stephanie L Baer Azeem Mohammed Sarah Tran Sandeep Padala Lufei Young Mufaddal Kheda Wendy B Bollag Source Type: research

Cardiovascular events risk in patients with systemic autoimmune diseases: a prognostic systematic review and meta-analysis
CONCLUSION: Patients with SAD present an increased risk of CV morbidity and mortality, which should be considered when establishing therapeutic strategies. These findings support the role of systemic inflammation in the development of atherosclerosis-driven disease.PMID:37650912 | DOI:10.1007/s00392-023-02291-4
Source: Atherosclerosis - August 31, 2023 Category: Cardiology Authors: Claudia Asenjo-Lobos Leticia Gonz ález Juan Francisco Bulnes Marta Roque Paula Mu ñoz Venturelli Gonzalo Mart ínez Rodríguez Source Type: research

Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist
AbstractClimate change has a pervasive impact on health and is of clinical relevance to every organ system. Climate change-related factors impact the skin ’s capacity to maintain homeostasis, leading to a variety of cutaneous diseases. Stratospheric ozone depletion has led to increased risk of melanoma and keratinocyte carcinomas due to ultraviolet radiation exposure. Atopic dermatitis, psoriasis, pemphigus, acne vulgaris, melasma, and photoaging ar e all associated with rising levels of air pollution. Elevated temperatures due to global warming induce disruption of the skin microbiome, thereby impacting atopic dermatiti...
Source: American Journal of Clinical Dermatology - June 20, 2023 Category: Dermatology Source Type: research

469 Evidence of a causal relationship between stroke and psoriasis
Comorbid cardiovascular disease (including coronary artery disease [CAD] and stroke) is a major source of morbidity and mortality in people with psoriasis. A recent Mendelian randomization (MR) study has provided supportive evidence that lifetime risk of CAD is causally implicated in psoriasis development, independent of adiposity (Patricket al Nat Commun. 2022). However, it is currently unclear whether lifetime risk of stroke influences psoriasis risk. A two-sample MR approach was undertaken to evaluate the putative causal effect of stroke on psoriasis risk.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: R. Ramessur, J. Saklatvala, J. Barker, N. Dand, M. Simpson, C. Smith Source Type: research

Exploring the molecular underpinning of psoriasis and its associated comorbidities through network approach: cross talks of genes and pathways
3 Biotech. 2023 May;13(5):130. doi: 10.1007/s13205-023-03533-y. Epub 2023 Apr 13.ABSTRACTPatients with psoriasis often complain of several linked disorders including autoimmune and cardiometabolic diseases. Understanding of molecular link between psoriasis and associated comorbidities would be of great interest at the point of patient care management. Integrative unbiased network approach, indicates significant unidirectional gene overlap between psoriasis and its associated comorbid condition including obesity (31 upregulated and 26 downregulated), ischemic stroke (14 upregulated and 2 downregulated), dyslipidaemia (5 upr...
Source: Atherosclerosis - April 17, 2023 Category: Cardiology Authors: Saumya Choudhary Noor Saba Khan Rashi Verma Pallavi Saxena Harpreet Singh Arun Kumar Jain George Thomas Dibyabhaba Pradhan Neeraj Kumar Source Type: research

New paradigms in purinergic receptor ligand discovery
Neuropharmacology. 2023 Mar 13:109503. doi: 10.1016/j.neuropharm.2023.109503. Online ahead of print.ABSTRACTThe discovery and clinical implementation of modulators of adenosine, P2Y and P2X receptors have progressed dramatically in ∼50 years since Burnstock's definition of purinergic signaling. Although most clinical trials of selective ligands (agonists and antagonists) of these nineteen receptors failed, there is a renewed impetus to redirect efforts to new disease conditions and the discovery of more selective or targeted compounds with potentially reduced side effects, such as biased GPCR agonists. The elucidation of...
Source: Neuropharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Kenneth A Jacobson Balaram Pradhan Zhiwei Wen Asmita Pramanik Source Type: research

Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib
CONCLUSION: In tofacitinib-treated patients with PsA/PsO, increased ASCVD risk and baseline MetS were associated with higher IRs for MACE and malignancies. Our results support assessing CV risk in patients with PsA/PsO and suggest enhanced cancer monitoring in those with increased ASCVD risk.REGISTRATION CLINICALTRIALSGOV: NCT01877668/NCT01882439/NCT01976364/NCT00678210/NCT01710046/NCT01241591/NCT01186744/NCT01276639/NCT01309737/NCT01163253.PLAIN LANGUAGE SUMMARY: People who have psoriatic arthritis or psoriasis may have more heart-related problems and cancer if they have a higher risk of cardiovascular disease: A study in...
Source: Adv Data - February 13, 2023 Category: Epidemiology Authors: Lars E Kristensen Bruce Strober Denis Poddubnyy Ying-Ying Leung Hyejin Jo Kenneth Kwok Ivana Vranic Dona L Fleishaker Lara Fallon Arne Yndestad Dafna D Gladman Source Type: research

Impact of targeted therapies on the risk of cardiovascular events in patients with psoriasis and psoriatic arthritis: A  systematic review and aggregate data meta‐analysis of randomized controlled trials
ConclusionCurrent targeted therapies are not associated with the risk of CVEs. Based on the existing evidence, we reported here that a dosage reduction of targeted therapies was not recommended.
Source: International Journal of Rheumatic Diseases - February 10, 2023 Category: Rheumatology Authors: Ruyi Cai, Yinji Jin, Beidi Chen, Jinxia Zhao, Jiayu Zhai, Lin Zeng, Rong Mu Tags: REVIEW Source Type: research