469 Evidence of a causal relationship between stroke and psoriasis

Comorbid cardiovascular disease (including coronary artery disease [CAD] and stroke) is a major source of morbidity and mortality in people with psoriasis. A recent Mendelian randomization (MR) study has provided supportive evidence that lifetime risk of CAD is causally implicated in psoriasis development, independent of adiposity (Patricket al Nat Commun. 2022). However, it is currently unclear whether lifetime risk of stroke influences psoriasis risk. A two-sample MR approach was undertaken to evaluate the putative causal effect of stroke on psoriasis risk.

Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: R. Ramessur, J. Saklatvala, J. Barker, N. Dand, M. Simpson, C. Smith Source Type: research