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Condition: Dermatitis

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Implementation science into the public - pregnant women need to prenatal visit for allergy prevention?
Allergic diseases such as atopic dermatitis (AD), food allergy (FA), asthma and allergic rhinitis (AR) are common; according to a national birth cohort study in Japan, almost half of pregnant women reported a history of allergic disease.1 Given that genetic factors, including family history, are predictors of allergic diseases in offspring, we expect the birth of many infants who carry a high risk of developing allergies. Among allergy prevention strategies, the effectiveness of primary prevention of eczema in high-risk infants by the topical application of emollient during the neonatal period has been demonstrated in two ...
Source: Annals of Allergy, Asthma and Immunology - November 21, 2019 Category: Allergy & Immunology Authors: Kiwako Yamamoto-Hanada, John Ichiro Takayama, Mayako Saito-Abe, Masaki Futamura, Yukihiro Ohya Tags: Letters Source Type: research

Prenatal visits for allergy prevention
Allergic diseases, such as atopic dermatitis, food allergy, asthma, and allergic rhinitis, are common; according to a national birth cohort study in Japan, almost half of pregnant women reported a history of allergic disease.1 Given that genetic factors, including family history, are predictors of allergic diseases in offspring, we expect the birth of many infants with a high risk of developing allergies. Among allergy prevention strategies, the effectiveness of primary prevention of eczema in high-risk infants by the topical application of emollient during the neonatal period has been demonstrated in 2 randomized controlled trials (RCTs).
Source: Annals of Allergy, Asthma and Immunology - November 21, 2019 Category: Allergy & Immunology Authors: Kiwako Yamamoto-Hanada, John Ichiro Takayama, Mayako Saito-Abe, Masaki Futamura, Yukihiro Ohya Tags: Letters Source Type: research

Occupational Exposure to Metals and Solvents: Allergy and Airway Diseases
AbstractPurpose of ReviewOccupational allergic diseases (OAD) such as occupational contact dermatitis (OCD), occupational asthma (OA), and occupational rhinitis (OR) are the most prevalent occupational diseases in industrialized countries. The purpose of this review is to provide an update about the main occupational metal and solvent exposures related to allergy and airway diseases and to discuss newly defined causative agents and industries in this field.Recent FindingsCurrently for over 400 causative agents for OA and OCD, several hundreds of agents for OR have been identified. Although many studies have reported an ove...
Source: Current Allergy and Asthma Reports - June 5, 2020 Category: Allergy & Immunology Source Type: research

Allergy clinics in times of the SARS-CoV-2 pandemic: an integrated model
ConclusionDuring COVID-19 pandemic, allergists have the responsibility of balancing individual patients ’ needs with public health issues, and innovative tools, such as telemedicine and digital medicine services, can be helpful to reduce the risk of viral spreading while delivering up-to-date personalized care.
Source: Clinical and Translational Allergy - June 17, 2020 Category: Allergy & Immunology Source Type: research

Management of Allergic Patients During the COVID-19 Pandemic in Asia.
We report this consensus to support allergists and clinical immunologists to make optimal decisions under the urgent situation in Asia. PMID: 32638559 [PubMed]
Source: Allergy, Asthma and Immunology Research - July 10, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

The Origins of Allergy from a Systems Approach
The origin of allergic disease has traditionally been explained by IgEmediated immune responses to account for asthma, atopic dermatitis, atopic rhinitis, and food allergy. Research insights into disease origins support broader array of factors that predispose, initiate, or exacerbate altered immunity in allergic diseases: inherent epithelial barrier dysfunction, loss of immune tolerance, disturbances in gut and organ-specific microbiomes, diet, and age. Here, we discuss these influences that together form a better understanding of allergy as a systems disease.
Source: Annals of Allergy, Asthma and Immunology - July 19, 2020 Category: Allergy & Immunology Authors: James Walter Krempski, Christopher Dant, Kari C. Nadeau Tags: CME Reviews Source Type: research

Nummular Eczema: An Updated Review.
CONCLUSION: With proper treatment, nummular eczema can be cleared over a few weeks, although the course can be chronic and characterized by relapses and remissions. Moisturizing of the skin and avoidance of identifiable exacerbating factors such as hot water baths and harsh soaps may reduce the frequency of recurrence. Diseases that present with annular lesions may mimic nummular eczema and the differential diagnosis is broad. As such, physicians must be familiar with this condition so that an accurate diagnosis can be made, and appropriate treatment initiated. PMID: 32778043 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - August 13, 2020 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Biologics and Allergy Immunotherapy in the Treatment of Allergic Diseases
Allergic diseases represent some of the most chronic and costly chronic conditions. Medical management may require long-term pharmacotherapy, which is often associated with poor adherence. Although medications provide symptomatic control, they do not modify the allergic disease. Patients may prefer disease-modifying treatments that provide lasting benefits after discontinuation. To date, allergy immunotherapy is the only proved disease modification therapy associated with lasting benefits after discontinuation. However, allergy immunotherapy safety and efficacy has only been established in allergic rhinitis, mild to modera...
Source: Immunology and Allergy Clinics of North America - September 11, 2020 Category: Allergy & Immunology Authors: Linda Cox Source Type: research

Heterogeneity of Childhood Asthma in Korea: Cluster Analysis of the Korean Childhood Asthma Study Cohort.
CONCLUSIONS: The asthma phenotypes among Korean children can be classified into 4 distinct clusters. Long-term follow-up with these phenotypes will be needed to define their prognosis and response to treatment. PMID: 33191676 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Advances in cutaneous allergy
Atopic dermatitis (AD) has now been well documented to be associated with an important impact on quality of life and is a major driver of not only systemic comorbidities including other allergic diseases (such as asthma and food allergy) but also cardiovascular and autoimmune diseases.1 Sleep disturbance and adverse effects on mental health are common in patients with AD. A major contributor for these events is the skin and resultant systemic immune activation associated with AD.2 Recent studies support the importance of skin barrier dysfunction in driving cutaneous allergy.
Source: Annals of Allergy, Asthma and Immunology - December 6, 2020 Category: Allergy & Immunology Authors: Donald Y.M. Leung Tags: Editorial Source Type: research

No difference in omalizumab efficacy in patients with asthma by number of asthma-related/allergic comorbidities.
CONCLUSION: In these analyses of placebo-controlled/single-armed studies, on-study exacerbation rates/FEV1 improvements with omalizumab treatment were similar irrespective of comorbidity burden. PMID: 33465457 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 16, 2021 Category: Allergy & Immunology Authors: Chen M, Choo E, Yoo B, Raut P, Haselkorn T, Pazwash H, Holweg CTJ, Hudes G Tags: Ann Allergy Asthma Immunol Source Type: research

Prevalence of Food Allergy Diagnosis in Moderate-Severe Atopic Dermatitis Pediatric Patients Referred to Allergy and/or Dermatology Subspecialty Clinics
Prevalence of food allergy (FA) and atopic dermatitis (AD) have increased. However, the updated prevalence of FA among AD patients and how they present is not well characterized.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jennifer Li, Lisa Arkin, Anne Marie Singh Source Type: research

From the Pages of Allergy Watch
For this installment of ‘From the Pages of Allergy Watch’ I've selected articles from the July-Aug issue. The first, reviewed by Dr Lee, suggests that pretreatment with H1& H2 antihistamines and montelukast can reduce the risk for reaction to COVID-19 vaccination. The next, reviewed by Dr Hernandez-Trujillo, reports data suggesting that alpha-gal allergy can be a problem even in areas not endemic for the lone star tick. The last article, reviewed by Dr Joshi, presented data suggesting that children with more severe atopic dermatitis are more likely to have learning disabilities.
Source: Annals of Allergy, Asthma and Immunology - September 17, 2021 Category: Allergy & Immunology Authors: Stanley Fineman, Gerald B. Lee, Vivian Hernandez-Trujillo, Shyam Joshi Tags: Special Series Source Type: research

Strategies for choosing a biologic for your patient with allergy or asthma
CONCLUSION: The numerous biologic options have made the selection of the best biologic for each patient a potential conundrum for clinicians. Adequate point of care biomarkers to facilitate personalized medical therapy are generally lacking. Furthermore, although clinically effective and generally safe, none of the biologics discussed in this review have induced long-standing disease remission. Nevertheless, these agents have given us the opportunity to treat the most severe patients and to better understand the biology of respiratory and allergic diseases. As knowledgeable physicians, we should embrace and be educated on ...
Source: Annals of Allergy, Asthma and Immunology - October 13, 2021 Category: Allergy & Immunology Authors: Tara Saco Israel C Ugalde Juan Carlos Cardet Thomas B Casale Source Type: research