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Psychological and social factors affecting internet searches on suicide in Korea: a big data analysis of google search trends.
Conclusion: A positive relationship between stress- and suicide-related searches further confirmed that stress affects suicide. Taken together and viewed in context of the big data analysis, our results point to the need for a tailored prevention program. Real-time big data can be of use in indicating increases in suicidality when search words such as stress and suicide generate greater numbers of hits on portals and social network sites.
PMID: 24339315 [PubMed - in process]
Source: Yonsei Medical Journal - December 19, 2013 Category: Universities & Medical Training Authors: Song TM, Song J, An JY, Hayman LL, Woo JM Tags: Yonsei Med J Source Type: research
Effects of sialidase NEU1 siRNA on proliferation, apoptosis, and invasion in human ovarian cancer.
In conclusion, NEU1 siRNA can effectively inhibit proliferation, apoptosis, and invasion of human ovarian cancer cells by targeting lysosome and oxidative phosphorylation signaling, which can serve as a new target ovarian cancer treatment.
PMID: 26463994 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - October 13, 2015 Category: Biochemistry Authors: Ren LR, Zhang LP, Huang SY, Zhu YF, Li WJ, Fang SY, Shen L, Gao YL Tags: Mol Cell Biochem Source Type: research
SiRNA-mediated silencing of Snail-1 induces apoptosis and alters micro RNA expression in human urinary bladder cancer cell line.
Authors: Musavi Shenas SM, Mansoori B, Mohammadi A, Salehi S, Kaffash B, Talebi B, Babaloo Z, Shanehbandi D, Baradaran B
Abstract
Snail-1 known as one of the important transcription factor is a mediator of survival and cell migration, and expression is raised in numerous cancer types. Snail-1 gene may show a role in recurrence of several cancers including bladder cancer by down-regulating E-cadherin, inducing an epithelial to mesenchymal transition (EMT) and its related microRNAs (miRNAs). The aim of this study was to investigate the effect of a specific Snail-1 siRNA on apoptosis and alter EMT related miRNAs of EJ...
Source: Artificial Cells, Nanomedicine and Biotechnology - June 22, 2016 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Myosin light chain kinase controls voltage-dependent calcium channels in vascular smooth muscle.
This study was designed to investigate whether MLCK is involved in Ca(2+) regulation in resistance artery smooth muscle cell, which plays a major role in the control of blood pressure. As ML compounds were shown to have off-target effects, MLCK was downregulated by transfection with a small interfering RNA targeting MLCK (MLCK-siRNA) in rat small resistance mesenteric artery (RMA) and in the rat embryonic aortic cell line A7r5. Noradrenaline-induced contraction and Ca(2+) signal were significantly depressed in MLCK-siRNA compared to scramble-siRNA-transfected RMA. Contraction and Ca(2+) signal induced by high KCl and volta...
Source: Pflugers Archiv : European Journal of Physiology - October 27, 2013 Category: Physiology Authors: Martinsen A, Schakman O, Yerna X, Dessy C, Morel N Tags: Pflugers Arch Source Type: research
Trends of Internet Search Volumes for Major Depressive Disorder Symptoms During the COVID-19 Pandemic in Korea: An Interrupted Time-Series Analysis
CONCLUSION: Our results reported the negative effect of COVID-19 preventive measures on public mental health in South Korea, especially for MDD symptoms. Moreover, the findings suggested the utility of Naver Trends as a feasible big data source to assess future mental health crises.PMID:35411728 | DOI:10.3346/jkms.2022.37.e108
Source: J Korean Med Sci - April 12, 2022 Category: General Medicine Authors: Jieun Kim Juhui Han Byung Chul Chun Source Type: research
Comparing the Safety and Effectiveness of Ketamine Versus Benzodiazepine/Opioid Combination for Procedural Sedation in Emergency Medicine: A Comprehensive Review and Meta-Analysis
This study compares the safety and efficacy of ketamine and midazolam/fentanyl. Two search methods were used to identify studies related to our topic, including a database search and a manual search involving screening reference lists of articles retrieved by the database search. A methodological quality appraisal was conducted on the articles suitable for inclusion using Cochrane's risk of bias tool in the Review Manager software (Review Manager (RevMan) (Computer program). Version 5.4, The Cochrane Collaboration, 2020). Moreover, pooled analysis was performed using the Review manager software. The study analyzed 1366 art...
Source: Pain Physician - May 1, 2023 Category: Anesthesiology Authors: Hany A Zaki Tarek Ibrahim Ahmed Osman Wael Abdelrehem Elnabawy Amr Gebril Ahmed H Hamdi Eslam Hussein Mohamed Source Type: research
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Source: Blog, Blah, Blah - December 22, 2013 Category: Nurses Authors: sara Tags: 1 Tv Guide Uk Source Type: blogs
Interventions for Prevention of Intimate Partner Violence Against Women in Humanitarian Settings: A Protocol for a Systematic Review
The objective of the systematic review is to identify existing IPV prevention interventions, strategies and programs among refugee, internally displaced, or conflict-affected female in humanitarian settings; and to assess their effects. It will seek to answer the following questions:
What are the existing types of intervention for primary or secondary prevention of IPV against women in humanitarian settings?
What is the effect of various types of interventions on prevention or reduction of physical, sexual or emotional IPV in humanitarian settings?
How do various types of intervention related to IPV affect he...
Source: PLOS Currents Disasters - July 12, 2017 Category: International Medicine & Public Health Authors: Marjan Delkhosh Source Type: research
