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Specialty: Chemistry
Condition: Depression

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Total 32 results found since Jan 2013.

Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols?
Abstract Post-stroke depression is a common neuropsychiatric affective disorder that may develop after a stroke event. In addition to abnormalities in the biogenic amine neurotransmitters and cytokine expression induced by stroke we will focus on the role of oxidative stress and hypothesize that polyphenols may be useful as therapeutics targets for the treatment of post-stroke depression. In this paper, we discuss the hypothesis that increased oxidative stress in cerebral tissues during ischemia is implicated in the pathogenesis of depressive-like symptoms following stroke. There is substantive evidence regarding ...
Source: Current Medicinal Chemistry - November 12, 2014 Category: Chemistry Authors: Nabavi SF, Dean OM, Turner A, Sureda A, Daglia M, Nabavi SM Tags: Curr Med Chem Source Type: research

Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke.
CONCLUSIONS: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors. PMID: 29325799 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - January 8, 2018 Category: Chemistry Authors: Yin J, Zhong C, Zhu Z, Bu X, Xu T, Guo L, Wang X, Zhang J, Cui Y, Li D, Zhang J, Ju Z, Chen CS, Chen J, Zhang Y, He J Tags: Clin Chim Acta Source Type: research

Behavioral Effects Of 2,3-Dihydro- And Oxoisoaporphine Derivatives In Post Stroke-Depressive Like Behavior In Male Balb/C Mice.
In this study antidepressant-like effects of intra-cerebroventricularly administration of oxoisoaporphine derivatives in post stroke-depressive like behavior were examined through despair swimming and tail suspension models. For this aim, acute ischemic stroke was induced by bilateral common carotid arteries occlusion which significantly changed the normal behaviors of male balb/c mice. We performed stroke-induced anhedonia test as a key result of post stroke-depressive like behavior by determination of sucrose consumption. Results show that some 2,3-dihydro- and oxoisoaporphine derivatives modified the abnormality in the ...
Source: Current Topics in Medicinal Chemistry - August 26, 2013 Category: Chemistry Authors: Nabavi SF, Sobarzo-Sánchez E, Nabavi SM, Daglia M, Moghaddam AH, Silva AG Tags: Curr Top Med Chem Source Type: research

The association between neutrophil-to-lymphocyte ratio and post-stroke depression.
CONCLUSIONS: Increased NLRs at admission are found to be correlated with PSD and may add prognostic information for the early discovery of PSD. PMID: 30130533 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - August 18, 2018 Category: Chemistry Authors: Chen H, Luan X, Zhao K, Qiu H, Liu Y, Tu X, Tang W, He J Tags: Clin Chim Acta Source Type: research

Serum ceramide concentrations are associated with depression in patients after ischemic stroke-A two-center case-controlled Study
CONCLUSION: There was a stage-specific association between serum ceramides and PSD, and the potential pathophysiological mechanism has to be investigated in future research.PMID:33775701 | DOI:10.1016/j.cca.2021.03.014
Source: International Journal of Clinical Chemistry - March 29, 2021 Category: Chemistry Authors: Lv Hong Wang Hongmei Xie Leijie Zou Dandan Liu Peng Hu Zhifei Ma Ruimin Shi Yijun Zheng Guanghui Zhang Guojun Source Type: research

Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin.
Abstract Synchronous measurement of brain neurotransmitters and blood drug metabolism by dual sites in vivo microdialysis can provide very important information for several neurological disorders such as post-stroke depression (PSD). In this work, d0/d3-6-N-methyl-rhodamine 6G-N-hydroxysuccinimidyl formate (d0/d3-MRSF) were firstly designed, synthesized and used as stable isotope labeling derivatization reagents for the determination of multiple neurotransmitters by ultra-high performance liquid chromatography-tandem mass spectrometry. The light d0-MRSF was used to label neurotransmitters in real samples and the ...
Source: Analytica Chimica Acta - January 23, 2019 Category: Chemistry Authors: Zhao XE, He Y, Zhu S, Xu Y, You J, Bai Y, Liu H Tags: Anal Chim Acta Source Type: research

Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: The SABPA study
Conclusions Chronic depression symptoms may alter NO regulation and facilitate VD. NO-mediated vasoconstriction presumably impeded perfusion, retinal hemodynamics and –remodelling; potentiating stroke risk in Blacks. Graphical abstract
Source: Nitric Oxide - March 3, 2016 Category: Chemistry Source Type: research

Molecules, Vol. 27, Pages 2484: Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
k Capsaicin is a natural compound found in chili peppers and is used in the diet of many countries. The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons. Furthermore, the beneficial effects of capsaicin in cardiovascular and oncological disorders have been described. Many recent publications show the positive effects of capsaicin in animal models of brain disorders. In Alzheimer’s disease, capsaicin reduces neurodegeneration and memory impairment. The beneficial effects of capsaicin in Parkinson’s disease and depression have also be...
Source: Molecules - April 12, 2022 Category: Chemistry Authors: Micha ł Pasierski Bart łomiej Szulczyk Tags: Review Source Type: research

Mechanistic insights into mode of action of a potent natural antagonist of orexin receptor-1 by means of high throughput screening and molecular dynamics simulations.
Abstract Insomnia is one of the most common clinical problems being faced by people all over the world. It adversely affects the routine life of these patients giving rise to even other health issues like hypertension, diabetes, obesity, depression, heart attack, and stroke. Orexin receptor-1 (OX1R), a noteworthy drug target, when inhibited can promote sleepiness in people suffering from such conditions. OX1R is a G-protein coupled receptor which is conserved throughout the mammalian species and is located primarily in hypothalamus and locus coeruleus. The present study aims at identifying potent natural-origin in...
Source: Combinatorial Chemistry and High Throughput Screening - October 3, 2013 Category: Chemistry Authors: Dhanjal JK, Grover S, Paruthi P, Sharma S, Grover A Tags: Comb Chem High Throughput Screen Source Type: research

Employment of Molecularly Imprinted Polymers to High-throughput Screen nNOS-PSD-95 Interruptions: Structure and Dynamics Investigations on Monomer-Template Complexation.
Abstract We here employ the molecularly imprinted polymers (MIPs) to screen nNOS-PSD-95 interruptions. 5-(3,5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid (ZL006, a potential drug candidates for the treatment of stroke, depression and pain) was employed as template. Four kinds of functional monomers (2-VP: 2-vinylpyridine; 4-VP: 4-vinylpyridine; MMA: methyl methacrylate; MAAM: methacrylamide) were designed, and their complexation with ZL006 in various solvents (methanol, acetonitrile, toluene, chloroform) were investigated by molecular dynamics (MD) simulations and quantum mechanics (QM) calculations. Both...
Source: Chemphyschem - January 5, 2016 Category: Chemistry Authors: Jiang N, Wang Y, Zhao T, Dai P, Li F Tags: Chemphyschem Source Type: research

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders.
Abstract The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to play crucial roles in the central and peripheral nervous systems. The activation of PAC1R initiates diverse downstream signal transduction pathways, including adenylyl cyclase, phospholipase C, MEK/ERK and Akt pathways that regulate a number of physiological systems to maintain functional homeostasis. Accordingly, at times of tissue injury or insult, PACAP/PAC...
Source: Current Topics in Medicinal Chemistry - July 7, 2019 Category: Chemistry Authors: Liao C, de Molliens MP, Schneebeli ST, Brewer M, Song G, Chatenet D, Braas KM, May V, Li J Tags: Curr Top Med Chem Source Type: research

Molecules, Vol. 25, Pages 4749: A Review of Molecular Imaging of Glutamate Receptors
umming Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) is a well-established and important in vivo technique to evaluate fundamental biological processes and unravel the role of neurotransmitter receptors in various neuropsychiatric disorders. Specific ligands are available for PET/SPECT studies of dopamine, serotonin, and opiate receptors, but corresponding development of radiotracers for receptors of glutamate, the main excitatory neurotransmitter in mammalian brain, has lagged behind. This state of affairs has persisted despite the central importance o...
Source: Molecules - October 16, 2020 Category: Chemistry Authors: Jong-Hoon Kim J ános Marton Simon Mensah Ametamey Paul Cumming Tags: Review Source Type: research