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Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy
CONCLUSIONS: The results from this study suggest that PTSD and CVD may share genetic risk. Further, these results implicate PTSD as a risk factor leading to the development of hypertension and coronary artery disease. Additional research is needed to determine the clinical utility of these findings.PMID:36069022 | DOI:10.1176/appi.ajp.21111113
Source: The American Journal of Psychiatry - September 7, 2022 Category: Psychiatry Authors: Antonia V Seligowski Burook Misganaw Lucie A Duffy Kerry J Ressler Guia Guffanti Source Type: research

COVID-19 Can Increase Risk of Psychiatric Disorders for Up to Two Years
The increased risk of depression and anxiety that patients experience after developing COVID-19 typically subsides within two months, according to astudy published yesterday inThe Lancet Psychiatry. However, patients may have an elevated risk for developing other psychiatric and neurological conditions, such as psychosis, brain fog, and seizures, for up to two years after their infections.“The results have important implications for patients and health services as it suggests new cases of neurological conditions linked to COVID-19 infection are likely to occur for a considerable time after the pandemic has subsided,” s...
Source: Psychiatr News - August 18, 2022 Category: Psychiatry Tags: adults anxiety brain fog children COVID-19 delta dementia depression older adults omicron psychotic disorder seizures The Lancet Psychiatry Source Type: research

More Research Is Needed on Lifestyle Behaviors That Influence Progression of Parkinson's Disease
This article highlights some of these challenges in the design of lifestyle studies in PD, and suggests a more coordinated international effort is required, including ongoing longitudinal observational studies. In combination with pharmaceutical treatments, healthy lifestyle behaviors may slow the progression of PD, empower patients, and reduce disease burden. For optimal care of people with PD, it is important to close this gap in current knowledge and discover whether such associations exist. Introduction Parkinson's disease (PD) is an age-related complex progressive neurodegenerative disorder, with key p...
Source: Frontiers in Neurology - April 29, 2019 Category: Neurology Source Type: research

Patterns and temporal trends of comorbidity among adult patients with incident cardiovascular disease in the UK between 2000 and 2014: A population-based cohort study
ConclusionsThe burden of multimorbidity and comorbidity in patients with incident non-fatal CVD increased between 2000 and 2014. On average, older patients, women, and socioeconomically deprived groups had higher numbers of comorbidities, but the type of comorbidities varied by age and sex. Cardiometabolic conditions contributed substantially to the burden, but 4 out of the 10 top comorbidities were non-cardiometabolic. The current single-disease paradigm in CVD management needs to broaden and incorporate the large and increasing burden of comorbidities.
Source: PLoS Medicine - March 6, 2018 Category: Internal Medicine Authors: Jenny Tran Source Type: research

Are healthcare costs from obesity associated with body mass index, comorbidity or depression? Cohort study using electronic health records
The objective of this study was to evaluate the association between body mass index (BMI) and healthcare costs in relation to obesity‐related comorbidity and depression. A population‐based cohort study was undertaken in the UK Clinical Practice Research Datalink (CPRD). A stratified random sample was taken of participants registered with general practices in England in 2008 and 2013. Person time was classified by BMI category and morbidity status using first diagnosis of diabetes (T2DM), coronary heart disease (CHD), stroke or malignant neoplasms. Participants were classified annually as depressed or not depressed. Cos...
Source: Clinical Obesity - March 31, 2016 Category: Eating Disorders and Weight Management Authors: C. Rudisill, J. Charlton, H. P. Booth, M. C. Gulliford Tags: Original Article Source Type: research

In Depth Neandertal genes linked to modern diseases
When modern humans met and mated with Neandertals about 50,000 years ago, they picked up genes that are shaping health and well-being today. In a new study on p. 737, researchers use a powerful new method for scanning the electronic health records of 28,000 Americans to show that some Neandertal gene variants today may boost the risk of depression, skin lesions, blood clots, and other disorders. The work reveals a dozen Neandertal genes likely to cause significant risk of disease today. Neandertal genes aren't all bad. Two other new studies identified three archaic genes that boost immune response. And most archaic genes t...
Source: ScienceNOW - February 12, 2016 Category: Science Authors: Ann Gibbons Tags: Human Evolution Source Type: news

Conformance to Depression Process Measures of Medicare Part B Beneficiaries in Primary Care Settings
ConclusionOnly a small proportion of Medicare beneficiaries received the recommended screening and follow‐up care needed to conform to the quality measures for depression in the primary care setting. Further evaluation of measures of depression care should be conducted before these measures are implemented widely.
Source: Journal of the American Geriatrics Society - June 26, 2015 Category: Geriatrics Authors: Elizabeth R. Pfoh, Ramin Mojtabai, Jennifer Bailey, Jonathan P. Weiner, Sydney M. Dy Tags: Clinical Investigations Source Type: research