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Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes
CONCLUSION: Although surgery was associated with a clinically and statistically significant improvement in sinonasal scores in cystic fibrosis patients, patients with pseudomonas may experience less benefit. Revision surgery and older age may be associated with less favorable pulmonary outcomes. Awareness of such variables may help when deciding which cystic fibrosis patients should undergo surgery.PMID:34806427 | DOI:10.1177/19458924211059606
Source: American Journal of Rhinology and Allergy - November 22, 2021 Category: ENT & OMF Authors: Keven S Y Ji Dennis Frank-Ito Ralph Abi Hachem Khalil Issa Carrie Johnson Omar Mohamedaly Bradley J Goldstein David W Jang Source Type: research

Effect of highly effective modulator therapy on quality of life in adults with cystic fibrosis
ConclusionCF patients taking elexacaftor/tezacaftor/ivacaftor experience a significant improvement in both sinonasal and health ‐related quality of life.
Source: International Forum of Allergy and Rhinology - September 28, 2020 Category: Allergy & Immunology Authors: Emily DiMango, Daniel B. Spielman, Jonathan Overdevest, Claire Keating, Sarah Fracasso Francis, David Dansky, David A. Gudis Tags: RESEARCH NOTE Source Type: research

Sinonasal quality ‐of‐life declines in cystic fibrosis patients with pulmonary exacerbations
ConclusionCF patients with pulmonary exacerbations have worse SNOT ‐22 and CFQ‐R 14+ scores than CF patients at their baseline health. This finding suggests a temporal relationship between sinonasal and pulmonary quality of life, and that worsening of both is associated with reduced pulmonary function.
Source: International Forum of Allergy and Rhinology - December 12, 2019 Category: Allergy & Immunology Authors: Chetan Safi, Emily DiMango, Claire Keating, Zian Zhou, David A. Gudis Tags: ORIGINAL ARTICLE Source Type: research

The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC –MS Based Metabolomics
Conclusion In this study, serum and urine metabolites identified by GC–MS and general pharmacodynamic evaluation (morphological observation, histopathology, inflammatory factors, and visceral indices) were used to compare the effects of GJ and LGWWJX decoctions on cold asthma. Significant metabolic abnormalities were observed for 37 metabolites (15 in serum, 22 in urine) in rats with cold asthma. These altered metabolites might be potential biomarkers or therapeutic targets during development of cold asthma. Furthermore, pathway analysis demonstrated that pathways associated with energy metabolism and oxidative str...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Ivacaftor improves rhinologic, psychologic, and sleep ‐related quality of life in G551D cystic fibrosis patients
ConclusionIvacaftor improves QOL in the R, P, and S domains in G551D CF patients, although QOL instruments validated for CRS may not translate well to CF CRS patients because symptom burden was surprisingly low.
Source: International Forum of Allergy and Rhinology - November 24, 2018 Category: Allergy & Immunology Authors: Justin McCormick, Do ‐Yeon Cho, Brooks Lampkin, Joshua Richman, Heather Hathorne, Steven M. Rowe, Bradford A. Woodworth Tags: ORIGINAL ARTICLE Source Type: research

Effect of Endoscopic Sinus Surgery on Bronchiectasis Patients With Chronic Rhinosinusitis.
Conclusion ESS is effective in improving long-term sinonasal outcomes in bronchiectasis patients with CRS. However, ESS does not appear to improve the pulmonary function. PMID: 30112923 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - August 16, 2018 Category: ENT & OMF Authors: Kanjanaumporn J, Hwang PH Tags: Am J Rhinol Allergy Source Type: research

F508del genotype in endoscopic sinus surgery: do differences in outcomes exist between genotypic subgroups?
ConclusionPrior studies investigating the impact of ESS on pulmonary function in CF patients have shown conflicting results. To our knowledge, those earlier udies did not separate and compare different genotypes, which may have introduced heterogeneity in their patient populations. Our study suggests that grouping CF patients more strictly according to genotype or disease severity when investigating outcomes may reveal differences among various subgroups.
Source: International Forum of Allergy and Rhinology - February 8, 2017 Category: Allergy & Immunology Authors: Ashleigh A. Halderman, Natalie West, James Benke, Christopher R. Roxbury, Sandra Y. Lin Tags: ORIGINAL ARTICLE Source Type: research

Determinants and outcomes of upfront surgery versus medical therapy for chronic rhinosinusitis in cystic fibrosis
ConclusionsSurgery effectively reduces CRS‐related symptoms in CF patients but may not improve pulmonary function. In patients who first pursue medical therapy, symptomatic decline may prompt eventual conversion to surgery. Patients who delay surgery may achieve similar outcomes as those who pursue surgery upfront.
Source: International Forum of Allergy and Rhinology - January 31, 2017 Category: Allergy & Immunology Authors: Noel Ayoub, Andrew Thamboo, Al ‐Rahim Habib, Jayakar V. Nayak, Peter H. Hwang Tags: ORIGINAL ARTICLE Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

Quantitative sinonasal symptom assessment in an unselected pediatric population with cystic fibrosis.
CONCLUSIONS: The SN-5 tool provides a quick, safe, and reliable qualitative metric for monitoring sinonasal symptoms in young children with CF. PMID: 26358346 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - September 1, 2015 Category: ENT & OMF Authors: Wentzel JL, Virella-Lowell I, Schlosser RJ, Soler ZM Tags: Am J Rhinol Allergy Source Type: research