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Condition: Obesity
Drug: Insulin

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Total 476 results found since Jan 2013.

Obesity: single house for many evils.
Authors: Kumar A, Nayak BP, Kumar A Abstract World Health Organization (WHO) considers obesity as one of the fastest growing metabolic disorders other than diabetes. It is a complex interplay of lifestyle and associated genes. Obesity has been considered as a disease with multiple targets and very often compared in this sense with its sibling disease type 2 diabetes. The disease is pathology of the adipocytes and develops as a result of hypertrophy and hyperplasia of these cells, former being the major concern but its effects could be seen on various organs in the form of cardio-vascular disease, stroke, cancer, di...
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Cardiovascular events and all-cause mortality with insulin versus glucagon-like peptide-1 analogue in type 2 diabetes
Conclusions In this cohort of obese people with T2DM, intensification of dual oral therapy by adding GLP-1ar analogue is associated with a lower MACE outcome in routine clinical practice, compared with adding insulin therapy as the third glucose-lowering agent.
Source: Heart - September 12, 2016 Category: Cardiology Authors: Anyanwagu, U., Mamza, J., Mehta, R., Donnelly, R., Idris, I. Tags: Drugs: cardiovascular system, Acute coronary syndromes, Epidemiology, Diabetes, Metabolic disorders Healthcare delivery, economics and global health Source Type: research

Cardiovascular Consequences of Childhood Secondhand Tobacco Smoke Exposure: Prevailing Evidence, Burden, and Racial and Socioeconomic Disparities: A Scientific Statement From the American Heart Association.
CONCLUSIONS: The epidemiological, observational, and experimental evidence accumulated to date demonstrates the detrimental cardiovascular consequences of SHS exposure in children. IMPLICATIONS: Increased awareness of the adverse, lifetime cardiovascular consequences of childhood SHS may facilitate the development of innovative individual, family-centered, and community health interventions to reduce and ideally eliminate SHS exposure in the vulnerable pediatric population. This evidence calls for a robust public health policy that embraces zero tolerance of childhood SHS exposure. PMID: 27619923 [PubMed - as supplied by publisher]
Source: Circulation - September 11, 2016 Category: Cardiology Authors: Raghuveer G, White DA, Hayman LL, Woo JG, Villafane J, Celermajer D, Ward KD, de Ferranti SD, Zachariah J, American Heart Association Committee on Atherosclerosis, Hypertension, and Obesity in the Young of the Council on Cardiovascular Disease in the Youn Tags: Circulation Source Type: research

Impact of Intermittent Fasting on Health and Disease Processes.
Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when associated with a sedentary lifestyle. Because animals, including humans, evolved in environments where food was relatively scarce, they developed numerous adaptations that enabled them to function at a high level, both physically and cognitively, when in a food-deprived/fasted state. Intermittent fasting (IF) enco...
Source: Ageing Research Reviews - October 30, 2016 Category: Genetics & Stem Cells Authors: Mattson MP, Longo VD, Harvie M Tags: Ageing Res Rev Source Type: research

Cardiovascular events and all ‐cause mortality associated with sulfonylureas compared to other antihyperglycaemic drugs: A Bayesian meta‐analysis of survival data
ConclusionThis meta‐analysis shows an association between sulfonylurea therapy and a higher risk of major cardiovascular disease‐related events compared to other antihyperglycaemic drugs. Results of ongoing RCTs, which should be available in 2018, will provide definitive results on the risk of cardiovascular events and all‐cause mortality associated with sulfonylureas versus other antihyperglycaemic drugs.
Source: Diabetes, Obesity and Metabolism - October 31, 2016 Category: Endocrinology Authors: Steve Bain, Eric Druyts, Chakrapani Balijepalli, Carl A Baxter, Craig Currie, Romita Das, Richard Donnelly, Kamlesh Khunti, Haya Langerman, Paul Leigh, Gaye Siliman, Kristian Thorlund, Kabirraaj Toor, Jiten Vora, Edward J Mills Tags: Original Article Source Type: research

Expensive New Diabetes Drugs Add Nothing But Cost And Complications
This is the fourth in an ongoing series of blogs exposing the rampant misuse of the medications so aggressively promoted by greedy drug companies. I am very lucky in having the perfect partner in this truth-vs-power effort to contradict Pharma propaganda with evidence based fact. Dick Bijl is President of the International Society of Drug Bulletins (ISDB), an impressive association of 53 national drug bulletins from all around the world, each of which publishes the best available data on the pluses and minuses of different medications. Drug bulletins help patients and doctors see through the misleading misinformation ge...
Source: Science - The Huffington Post - November 17, 2016 Category: Science Source Type: news

Declines In Dementia: Of Hearts And Minds
In this season when we are meant to be thankful, but when so many of us have had so many reasons to be otherwise, we have received a timely, welcome bit of universally good news. Rates of dementia in the United States appear to be declining. This news reaches us courtesy of a study published recently in JAMA Internal Medicine. The investigators used standard, validated measures of cognitive function and dementia in two groups of more than 10,000 people in the U.S. with an average age of roughly 75 in the year 2000, and again in 2012. The overall rate of dementia declined over that span from 11.6% to 8.8%. Taking ...
Source: Science - The Huffington Post - November 27, 2016 Category: Science Source Type: news

Why Diet Soda Could Actually Prevent You From Losing Weight
Reaching for a diet soda may actually hinder weight loss efforts, a new study done in mice suggests. In experiments, researchers found that the artificial sweetener aspartame, which is found in some diet drinks, may contribute to the development of a condition called “metabolic syndrome,” which involves a cluster of symptoms, including high blood pressure, high cholesterol levels and a large waist size. People with metabolic syndrome face an increased risk of heart disease, stroke and diabetes. The researchers found how aspartame could be linked with metabolic syndrome: Aspartame may stop a key gut enzyme ...
Source: Healthy Living - The Huffington Post - December 7, 2016 Category: Consumer Health News Source Type: news

Does Diet Soda Cause Weight Gain?
This study shows quite nicely that non-caloric sweeteners can alter gut microbes in mice -- a change that has negative metabolic consequences -- and provides preliminary evidence that it can happen in humans too. Unexpected consequences To further appreciate how complicated our handling of diet soda can be, here's another little example: Our intestine (or bowel) is covered with cells that secrete hormones. These cells react to the presence and composition of food by secreting peptides such as glucagon-like peptide 1 (GLP-1), peptide YY (PYY) and cholecystokinin - these names are not important - that work on the brain, sig...
Source: Healthy Living - The Huffington Post - December 7, 2016 Category: Consumer Health News Source Type: news

Why Diet Soda Could Actually Prevent You From Losing Weight
Reaching for a diet soda may actually hinder weight loss efforts, a new study done in mice suggests. In experiments, researchers found that the artificial sweetener aspartame, which is found in some diet drinks, may contribute to the development of a condition called “metabolic syndrome,” which involves a cluster of symptoms, including high blood pressure, high cholesterol levels and a large waist size. People with metabolic syndrome face an increased risk of heart disease, stroke and diabetes. The researchers found how aspartame could be linked with metabolic syndrome: Aspartame may stop a key gut enzyme ...
Source: Science - The Huffington Post - December 7, 2016 Category: Science Source Type: news

The Terrifying Way Not Sleeping Enough Actually Changes Your Gut
Studies link insufficient sleep to some pretty scary consequences, including an increased risk of stroke, heart disease, diabetes, obesity and even some cancers. Experts still don’t fully understand why not getting enough sleep is connected to all of these conditions, but new research published this month adds one piece to the puzzle: Not getting enough sleep may cause changes to gut bacteria that could fundamentally change our metabolism, affecting a host of bodily systems. Gut microbiota are the trillions of microorganisms living in our intestines that help keep our metabolism, immune system and othe...
Source: Science - The Huffington Post - December 23, 2016 Category: Science Source Type: news

Cardiovascular events and all ‐cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: A Bayesian meta‐analysis of survival data
ConclusionsThe present meta‐analysis showed an association between SU therapy and a higher risk of major cardiovascular disease‐related events compared with other glucose lowering drugs. Results of ongoing RCTs, which should be available in 2018, will provide definitive results on the risk of cardiovascular events and all‐cause mortality associated with SUs vs other antihyperglycaemic drugs.
Source: Diabetes, Obesity and Metabolism - December 22, 2016 Category: Endocrinology Authors: Steve Bain, Eric Druyts, Chakrapani Balijepalli, Carl A. Baxter, Craig J. Currie, Romita Das, Richard Donnelly, Kamlesh Khunti, Haya Langerman, Paul Leigh, Gaye Siliman, Kristian Thorlund, Kabirraaj Toor, Jiten Vora, Edward J. Mills Tags: ORIGINAL ARTICLE Source Type: research

7 Tips To Lower Diabetes Risk in Menopause During the Holidays
By now, most people have been to a holiday party or two. Lots of food, lots of eggnog and other carb laden alcoholic beverages, and lots of grazing all day long on all the boxes of candy friends and business acquaintances sent to us. It's easy to gain the five pounds most people gain during the holidays, and in the process, raise your blood sugar or glucose levels too high. That's your body letting you know you have prediabetes (higher than normal but still below diabetes levels) or diabetes, and unless you take action soon, your body won't like it. Diabetes silently sneaks up on you and if untreated, slowly weakens your ...
Source: Healthy Living - The Huffington Post - December 23, 2016 Category: Consumer Health News Source Type: news

Path of Translational Discovery of "Urological Complications of Obesity and Diabetes (UCOD)".
Abstract Diabetes Mellitus (DM) is a prevalent chronic disease. Type 1 diabetes mellitus (T1DM) is a metabolic disorder that is characterized by hyperglycemia in the context of absolute lack of insulin; whereas type 2 diabetes mellitus (T2DM) is due to insulin resistance-related relative insulin deficiency. Obesity is an established risk factor for T2DM. In comparison with T1DM, T2DM is more complex. The natural history of T2DM in most patients typically involves a course of obesity to impaired glucose tolerance, to insulin resistance and hyperglycemia. Diabetes causes some serious microvascular and macrovascular ...
Source: American Journal of Physiology. Renal Physiology - January 3, 2017 Category: Physiology Authors: Daneshgari F, Liu G, Hanna-Mitchell AT Tags: Am J Physiol Renal Physiol Source Type: research

Contribution of Maladaptive Adipose Tissue Expansion to Development of Cardiovascular Disease.
Authors: Jia G, Jia Y, Sowers JR Abstract The overweight and obesity epidemic has led to an increase in the metabolic syndrome and associated cardiovascular disease (CVD). These abnormalities include insulin resistance, type 2 diabetes mellitus, vascular stiffness, hypertension, stroke, and coronary heart disease. Visceral white adipocyte tissue (WAT) expansion and associated fibrosis/stiffness of WAT promote insulin resistance and CVD through increases in proinflammatory adipokines, oxidative stress, activation of renin-angiotensin-aldosterone system, dysregulation of adipocyte apoptosis and autophagy, dysfunction...
Source: Comprehensive Physiology - February 1, 2017 Category: Physiology Tags: Compr Physiol Source Type: research