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Condition: Menopause
Drug: Estradiol

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Total 520 results found since Jan 2013.

Sex hormones, the stool microbiome, and subclinical atherosclerosis in women with and without HIV
CONCLUSION: Serum sex hormones are significant predictors of stool microbiome diversity and composition, likely due in part to metabolic interactions. The gut microbiome may play a role in estrogen-related cardiovascular protection.PMID:37643897 | DOI:10.1210/clinem/dgad510
Source: Atherosclerosis - August 29, 2023 Category: Cardiology Authors: Brandilyn A Peters David B Hanna Yi Wang Kathleen M Weber Elizabeth Topper Allison A Appleton Anjali Sharma Howard N Hodis Nanette Santoro Chantal Guillemette Patrick Caron Rob Knight Robert D Burk Robert C Kaplan Qibin Qi Source Type: research

Functional Hypothalamic Amenorrhea and Preclinical Cardiovascular Disease
CONCLUSIONS: These results demonstrate endothelial dysfunction in one out of three young women with FHA. FHA may be a contributor to preclinical CVD, and it is not explained by hypoestrogenemia alone.PMID:37610989 | DOI:10.1210/clinem/dgad498
Source: The Journal of Clinical Endocrinology and Metabolism - August 23, 2023 Category: Endocrinology Authors: Chrisandra L Shufelt Mariam Saadedine Galen Cook-Wiens Margareta D Pisarska JoAnn E Manson Sarah L Berga Moshe Arditi Prediman K Shah C Noel Bairey Merz Source Type: research

Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition
This study suggests that immediate HRT after menopause, along with appropriate iron chelation, might provide benefits from AS.PMID:37561022 | PMC:PMC10414966 | DOI:10.7554/eLife.80494
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: Tianze Xu Jing Cai Lei Wang Li Xu Hongting Zhao Fudi Wang Esther G Meyron-Holtz Fanis Missirlis Tong Qiao Kuanyu Li Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Role of Estrogen Receptor α in Aging and Chronic Disease
Adv Geriatr Med Res. 2023;5(2):e230005. doi: 10.20900/agmr20230005. Epub 2023 Jun 6.ABSTRACTEstrogen receptor alpha (ERα) plays a crucial role in reproductive function in both sexes. It also mediates cellular responses to estrogens in multiple nonreproductive organ systems, many of which regulate systemic metabolic homeostasis and inflammatory processes in mammals. The loss of estrogens and/or ERα agonism during aging is associated with the emergence of several comorbid conditions, particularly in females undergoing the menopausal transition. Emerging data also suggests that male mammals likely benefit from ERα agonism ...
Source: Adv Data - July 10, 2023 Category: Epidemiology Authors: Jos é V V Isola Sunghwan Ko Sarah R Oca ñas Michael B Stout Source Type: research

Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD-induced menopausal mice
CONCLUSION: Exercise ameliorates anxiety behavior, promotes hippocampal dentate gyrus neurogenesis, and inhibits hippocampal cell apoptosis in VCD-induced menopausal mice. They are related to circulating osteocalcin, which are increased by exercise.PMID:37402694 | DOI:10.1111/cns.14324
Source: CNS Neuroscience and Therapeutics - July 4, 2023 Category: Neuroscience Authors: Yiting Kang Jie Yao Xiaohang Gao Hao Zhong Yifei Song Xiaohui Di Zeguo Feng Lin Xie Jianbao Zhang Source Type: research

Sex hormones dose escalation for treating abnormal sleep in ovariectomized rats. In vitro GABA synthesis in brain areas sleep-related
Can J Physiol Pharmacol. 2023 Jun 26. doi: 10.1139/cjpp-2022-0524. Online ahead of print.ABSTRACTThe main aim of this study was to determine the maximum tolerated dose (MTD) of estradiol, progesterone, and a mixture of both to restore normal sleep in a model of rats' menopause. The second purpose was to describe the in vitro activity of glutamate decarboxylase (GAD) in sleep-related brain areas in the presence or absence of sex hormones. Ovariectomy increased periodic awakenings compared to those determined for the SHAM group. The estradiol+progesterone treatment for ovariectomized rats was effective by the fifth week in d...
Source: Canadian Journal of Physiology and Pharmacology - June 26, 2023 Category: Drugs & Pharmacology Authors: Nayely Carrasco-Nu ñes Martha Romano Marisa Cabeza Source Type: research