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Relative Effect of Current Intensive Lipid-Lowering Drugs on Cardiovascular Outcomes in Secondary Prevention 　- A Meta-Analysis of 12 Randomized Trials.
CONCLUSIONS: In secondary prevention patients, the relative benefits of high-dose statin, ezetimibe-statin, and PCSK9 inhibitor-statin treatments were varied and decreased gradually, of which high-dose statin was significantly superior to PCSK9 inhibitor-statin for improving MACE and revascularization per 1 mmol/L reduction of LDL-C. PMID: 31006730 [PubMed - as supplied by publisher]
Source: Circulation Journal - April 18, 2019 Category: Cardiology Authors: Wang S, Xiu J, Liao W, Liao Y, Bin J Tags: Circ J Source Type: research

Cultural Barriers in the Treatment of Dyslipidemia: A Survey of Japanese Physician Attitudes.
CONCLUSIONS: Awareness of target values for lipid management and of adverse reactions to drug therapy appears to vary somewhat depending on the participant's medical specialty. We also found that FH is probably underdiagnosed in Japan today. Further educations on proper diagnosis and management of dyslipidemia are required for physicians who are not specialized in cardiovascular health. PMID: 29780067 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - May 22, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial.
CONCLUSIONS: High-dose (4 mg/d) compared with low-dose (1 mg/d) pitavastatin therapy significantly reduced cardiovascular events in Japanese patients with stable coronary artery disease. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01042730. PMID: 29735587 [PubMed - in process]
Source: Circulation - May 8, 2018 Category: Cardiology Authors: Taguchi I, Iimuro S, Iwata H, Takashima H, Abe M, Amiya E, Ogawa T, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Miyauchi K, Yamazaki T, Ito H, Otsuji Y, Kimura K, Takahashi J, Hirayama A, Yokoi H, Kitagawa K, Urabe T, Okada Y, T Tags: Circulation Source Type: research

Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population.
CONCLUSION: LINE-1 DNA hypermethylation in leukocytes was associated with CVD risk profiles: high LDLC, high LDL/HDL ratio, and the degree of abnormal lipid metabolism. PMID: 29628482 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - April 11, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Age at death of major cardiovascular diseases in 13 cohorts. The seven countries study of cardiovascular diseases 45-year follow-up.
CONCLUSIONS: AD is a useful indicator of previous health and aging populations. STR and HDUE are diseases appearing later in life, thus being associated with a higher AD compared with CHD mortality. PMID: 29570017 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - March 28, 2018 Category: Cardiology Tags: Acta Cardiol Source Type: research

Rationale and Design of Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy with Pitavastatin in Coronary Artery Disease (REAL-CAD) Trial.
Authors: Miyauchi K, Kimura T, Shimokawa H, Daida H, Iimuro S, Iwata H, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Ohashi Y, Ohtsu H, Saito Y, Matsuzaki M, Nagai R, REAL-CAD Trial Investigaters Abstract Large-scale clinical trials in patients in Western countries with coronary artery disease (CAD) have found that aggressive lipid-lowering therapy using high-dose statins reduces cardiovascular (CV) events further than low-dose statins. However, such evidence has not yet been fully established in Asian populations, including in Japan. The Randomized Evaluation of Aggressive or Moderate Lip...
Source: International Heart Journal - March 6, 2018 Category: Cardiology Tags: Int Heart J Source Type: research

Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study.
CONCLUSION: Baseline mean and maximum values of carotid IMT in Japanese noncardioembolic stroke patients with hyperlipidemia were 0.89±0.15 mm and 1.19±0.32 mm, respectively, which were similar to those previously reported from Western countries. Age, smoking, hypertension, HDL cholesterol, and diabetes mellitus were associated with mean IMT, and those, except for hypertension, were associated with maximum IMT. PMID: 29118311 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - November 11, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Clinical Characteristics and Long-Term Outcomes of Rotational Atherectomy 　- J2T Multicenter Registry.
CONCLUSIONS: This study has provided the largest Japanese dataset for long-term follow-up of RA. Although RA in calcified lesions appears feasible with a high rate of procedural success, a high incidence of MACE was observed. PMID: 28931790 [PubMed - as supplied by publisher]
Source: Circulation Journal - September 21, 2017 Category: Cardiology Authors: Okai I, Dohi T, Okazaki S, Jujo K, Nakashima M, Otsuki H, Tanaka K, Arashi H, Okabe R, Nagura F, Nara Y, Tamura H, Kurata T, Kawashima H, Kyono H, Yamaguchi J, Miyauchi K, Kozuma K, Hagiwara N, Daida H Tags: Circ J Source Type: research

Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study
Although low high-density lipoprotein (HDL) cholesterol concentration is an established risk factor for coronary heart disease (CHD), information regarding subtypes of stroke is very limited, especially in Asian populations.
Source: Atherosclerosis - September 1, 2017 Category: Cardiology Authors: Isao Saito, Kazumasa Yamagishi, Yoshihiro Kokubo, Hiroshi Yatsuya, Hiroyasu Iso, Norie Sawada, Manami Inoue, Shoichiro Tsugane Source Type: research

Low-density lipoprotein cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidaemia: the HIJ-PROPER study, a prospective, open-label, randomized trial
ConclusionAlthough intensive lowering with standard pitavastatin plus ezetimibe showed no more cardiovascular benefit than standard pitavastatin monotherapy in ACS patients with dyslipidaemia, statin plus ezetimibe may be more effective than statin monotherapy in patients with higher cholesterol absorption; further confirmation is needed.Trial NoUMIN000002742, registered as an International Standard Randomized Controlled Trial.
Source: European Heart Journal - April 18, 2017 Category: Cardiology Source Type: research

Lipid Management in a Japanese Community:Attainment Rate of Target Set by the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 2012.
CONCLUSIONS: Lipid management is inadequate in community-based settings, particularly, in subjects with CKD and secondary prevention. PMID: 27568728 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - August 30, 2016 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Development of a Risk Equation for the Incidence of Coronary Artery Disease and Ischemic Stroke for Middle-Aged Japanese　- Japan Public Health Center-Based Prospective Study.
CONCLUSIONS: Risk equations were developed to estimate the 10-year probability of CAD and ischemic stroke in Japanese people, using variables that are routinely obtained. PMID: 27087361 [PubMed - as supplied by publisher]
Source: Circulation Journal - April 14, 2016 Category: Cardiology Authors: Yatsuya H, Iso H, Li Y, Yamagishi K, Kokubo Y, Saito I, Sawada N, Inoue M, Tsugane S Tags: Circ J Source Type: research

Combined Effect of Blood Pressure and Total Cholesterol Levels on Long-Term Risks of Subtypes of Cardiovascular Death: Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Epidemiology/Population
No large-scale, longitudinal studies have examined the combined effects of blood pressure (BP) and total cholesterol levels on long-term risks for subtypes of cardiovascular death in an Asian population. To investigate these relationships, a meta-analysis of individual participant data, which included 73 916 Japanese subjects (age, 57.7 years; men, 41.1%) from 11 cohorts, was conducted. During a mean follow-up of 15.0 years, deaths from coronary heart disease, ischemic stroke, and intraparenchymal hemorrhage occurred in 770, 724, and 345 cases, respectively. Cohort-stratified Cox proportional hazard models were used. After...
Source: Hypertension - February 11, 2015 Category: Cardiology Authors: Satoh, M., Ohkubo, T., Asayama, K., Murakami, Y., Sakurai, M., Nakagawa, H., Iso, H., Okayama, A., Miura, K., Imai, Y., Ueshima, H., Okamura, T., on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Res Tags: Lipids, Epidemiology Epidemiology/Population Source Type: research

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